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Tetraphase Pharmaceuticals, Inc. Message Board

  • stockdoc77 stockdoc77 Jan 9, 2014 10:29 AM Flag

    Enavercycline is the real deal

    I'm a critical care doctor and deal with multi drug resistant infections all the time. Looked at their p2 and lab data and the lead antibiotic enavercycline looks great. It has activity against all the major drug resistant bacteria except pseudomonas. In the P2 it was equally effective to meropenem which is one of the most potent IV antibiotics. Tetracyclines are very safe antibiotics and don't have major toxicities such as kidney failure that limit their use. The fact that enavercycline can likely also be given orally makes this a potential blockbuster drug. If the P3 comes in showing effciacy, this could be a billion dollars annual worldwide sales. The problem for the last 4 decades was that tetracyclines were so complex they could not be synthesized and modified from scratch, they had to be generated from tetracycline producing bacteria. TTPH has patented a chemical process that allows them to build tetracyclines from scratch and modify them to overcome current bacterial resistance, they have made over 1000 different variations in the lab and took the best compound to be their lead product. They have 2 or 3 more on the way in the pipeline. This stock is way under the radar if you look at the anemic volume, but someone is buying.

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