Today is a minor consideration in the trading of most stocks. There are many, many traders unavailable due to holidays; some tax loss selling; and just general malaise to trade stocks until the New Year 2011 rolls around. Unless there is some surprising news story, the market will be very sleepy. IMO, APRI will be a worthwhile investment for the new year. These biotech stocks take awhile and patience is necessary. A few cents change up or down is only the machinations of a tradable market. Meaningless in the long term. Good luck to all APRI investors and Happy New Year.