People resort to HA or steroids because they are in pain and even slight relief is better than doing nothing. Until Ampion is in the market there is really nothing to provide meaningful short or long term relief without significant side effects.
I believe when Ampion is approved it will be the only efficacious and safest therapy for the patients most in need.
Bill Williams used to post about herbal remedies as well as other substances as competition to Ampion. That’s what earned him the nickname “Ben Gay”. Not surprising since the goal of his more than 3,000 posts is to cast doubt on the value of Ampion and AMPE all in support of the shorts who pay him to salt social media with his authoritative sounding yet intentionally misleading and negatively nuanced posts.
Now he suggests that yet to be approved drugs which are combinations of HA and steroids are going to be meaningful drugs in the OA marketplace. Bill knows HA doesn’t work well. It is still being sold only because there is nothing else on the market that does work without significant side effects, i.e. nsaids and steroids. And even those two do nothing to help the most severely afflicted patients-KL4s.
The American Academy of Orthopaedic Surgeons could not recommend using HA for knee OA. Various insurers no longer reimburse for its use.
Combing the HA with steroids doesn’t eliminate the reasons why physicians have turned to steroids to treat OA only sparingly. The side effects, particularly of extended use, are significant and unacceptable for most treating physicians. I challenge anyone to ask an orthopedic surgeon, as I have with many, if they would consider long term steroid use, slow release or not, for a patient with severe knee OA.
Their answers are a resounding no. If these patients ultimately need knee replacement, which unfortunately many do, the steroids can make that impossible due to joint tissue damage associated with steroid use in the knee.
In that event the patient is left without any options to alleviate severe pain.
Furthermore even Bill concedes that steroids don’t work for the KL-4s, a huge unserved market.