sears has to be the most screwed up company in the US. They are stupid and lazy. Case in point: I wanted new ignition for sears tractor part no. 163968. I go to sears web site and they tell me this part is unavailable....I go to ebay and there are 24 parts available for 163968....Sears is such a zombie company they haven't linked their web site to direct order and ship vendors who sell replacement parts for their products. The part they told me is unavailable is available..It's just unavailable on sears.com and sears isn't making any effort to capture the revenue...I paid $17 for the part....sears could have linked me to an outside vendor and sold it to me for $22.50....what a bunch of lazy bums.
We should like to analyse our experience of renal failure in association
with jaundice during the years 1956-1964 at Hammersmith Hospital.
During this period 384 patients have required dialysis treatment
for acute or acute on chronic renal failure, and of these 81, or 21% have
been jaundiced, defined as a serum bilirubin over l. 5 mg. %. A further
five patients were reported to be clinically icteric, but as the serum
bilirubin was not measured they have not been included. We have omitted
from consideration all patients with renal failure who recovered on conservative
management alone, all patients who died of their primary disease
before dialysis was considered necessary, or who died before dialysis could
be undertaken. Thus we are only considering here a group of patients
with severe renal failure whose blood ureas all exceeded 350 mg. % at
some point in their illness.
The 81 patients have been subdivided into 12 groups depending on
the predominant aetiology of the jaundice ( Table I ). There is some degree
of overlap in the groups as there may be mild haemolysis in some obstetric
patients, and infection was obviously present in some patients with obstructive
ARAMCO going to buy MPC and all the other refiners after their $2T IPO. Then they will unveil the new technology of converting water to wine.
Miravirsen is a mir-122 inhibitor similar in principal to Rg-101 that was also being developed in San Diego....Roche bought Sabtaris for $485M......At this point I think one of the big biotechs should step in and pick up RGLS on the cheap.
even worse is the Isis inspired Orlando mass killer was seen at the Pulse night club with the gay alligator that ate the two 2 year old at Disney.
The gift of 100,000 chickens is to be distributed among countries with high poverty levels: mostly nations in sub-Saharan Africa, but also including Bolivia, reports Reuters.
I agree with the Constitution that all Americans have the right to bear arms. When this amendment was adopted two hundred years ago it pertained to single shot, musket toting militas I see no Constitutional language or construction that says Americans are entitled to bear concealed weapons..
this is a no gain situation....it will take 27 years to treat 100M people at current price/treatment rate....3M new cases a year x 27 years = 81M new cases in 27 years............drop price of harvoni quadruple treatment rate
If GILD drops the price of its HCV drugs 97% and treats 150,000,000 infected globally for $2.500/cure....HCV doesn't exist in 2 years, but GILD will have paid out $240/share in dividends ..Board has fiduciary duty
Tile: "Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy"
Lymphoid organs, in which antigen presenting cells (APCs) are in close proximity to T cells, are the ideal microenvironment for efficient priming and amplification of T-cell responses1. However, the systemic delivery of vaccine antigens into dendritic cells (DCs) is hampered by various technical challenges. Here we show that DCs can be targeted precisely and effectively in vivo using intravenously administered RNA-lipoplexes (RNA-LPX) based on well-known lipid carriers by optimally adjusting net charge, without the need for functionalization of particles with molecular ligands. The LPX protects RNA from extracellular ribonucleases and mediates its efficient uptake and expression of the encoded antigen by DC populations and macrophages in various lymphoid compartments. RNA-LPX triggers interferon-α (IFNα) release by plasmacytoid DCs and macrophages. Consequently, DC maturation in situ and inflammatory immune mechanisms reminiscent of those in the early systemic phase of viral infection are activated2. We show that RNA-LPX encoding viral or mutant neo-antigens or endogenous self-antigens induce strong effector and memory T-cell responses, and mediate potent IFNα-dependent rejection of progressive tumours. A phase I dose-escalation trial testing RNA-LPX that encode shared tumour antigens is ongoing. In the first three melanoma patients treated at a low-dose level, IFNα and strong antigen-specific T-cell responses were induced, supporting the identified mode of action and potency. As any polypeptide-based antigen can be encoded as RNA3, 4, RNA-LPX represent a universally applicable vaccine class for systemic DC targeting and synchronized induction of both highly potent adaptive as well as type-I-IFN-mediated innate immune mechanisms for cancer immunotherapy.
I'm being very charitable to GILD. It's current market cap represents a cure cost of $800/person x 150 million. Maybe $1600/cure globally would be more acceptable to you.