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The Empire District Electric Company Message Board

beeglebatty 28 posts  |  Last Activity: Jul 18, 2016 7:52 PM Member since: Jun 21, 2008
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  • Recently published Abstract on Acthar for Migraines. Sorry if this has already been posted.

    Objective: The goal of this study was to examine the effects of ACTH gel in chronic migraine patients who had failed multiple preventative treatments. Background: Despite the availability of many therapies for migraine prevention, there remain a significant number of patients whose migraines are refractory to treatment. Adrenocorticotropic hormone (ACTH) causes the release of glucocorticoids and has anti-inflammatory effects though melanocortin signaling, suggesting it might serve as a novel treatment for migraine prevention. Methods: This was a four center, two-arm, open-label study with 30 randomized subjects. All subjects met ICHD-IIR criteria for a diagnosis of chronic migraine and previously had failed at least two oral migraine preventatives as well as onabotulinumtoxinA. Following a 30-day baseline data collection period, subjects were randomized to receive either 40 IU or 80 IU of subcutaneous ACTH for 4 weeks. After the treatment phase subjects were followed for an additional 6 months. Results: When comparing baseline to treatment phase for all patients, we found a significant decrease in headache days (-2.2, p = .01) and migraine days (-2.2, p = .03). This reduction in headache days was greater for those receiving 80 IU than 40 IU, with those receiving 80 IU reporting a significant reduction in headache days (-2.6, p = .01) while the 40IU group had no significant change is headache days (-1.8, p = .21). A significant reduction in monthly headache days continued throughout the 6 month follow-up phase of the study F (7, 22) = .91, p = .03. Conclusions: Data from this pilot study suggest ACTH may be effective in reducing headache frequency in previously treatment-refractory patients with chronic migraine. Further investigation involving a larger subject population and double-blind methodology is needed to confirm this preliminary result.

    Beegz

  • Reply to

    BIG BIDS FOR ME AT 57

    by bioballs2014 May 6, 2016 9:48 AM
    beeglebatty beeglebatty May 6, 2016 5:21 PM Flag

    Has it bottomed? Beegz

  • Reply to

    SEC S-8 Filing AH

    by beeglebatty May 4, 2016 5:11 PM
    beeglebatty beeglebatty May 4, 2016 5:56 PM Flag

    Yeah Buddy ;-)

  • Reply to

    SEC S-8 Filing AH

    by beeglebatty May 4, 2016 5:11 PM
    beeglebatty beeglebatty May 4, 2016 5:20 PM Flag

    Yeah Man!! This Missouri and OKla stuff can get bad. Hehehe!! Stay safe Brother. Beegz

  • beeglebatty by beeglebatty May 4, 2016 5:11 PM Flag

    FYI Securities to be offered to employees in employee benefit plans...........Beegz

  • Reply to

    Chase Has No Audience

    by ohbabyno132 Apr 30, 2016 3:38 PM
    beeglebatty beeglebatty Apr 30, 2016 4:49 PM Flag

    I don't think Chase really cares but that is just me.

  • Reply to

    Last chance to exit in the $60s

    by ndibari73 Apr 26, 2016 12:03 PM
    beeglebatty beeglebatty Apr 26, 2016 5:56 PM Flag

    Bucket!! lol Beegz

  • Reply to

    Last chance to exit in the $60s

    by ndibari73 Apr 26, 2016 12:03 PM
    beeglebatty beeglebatty Apr 26, 2016 5:54 PM Flag

    Beegz is here everyday. Why post if there is nothing to post. Beegz.

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