It shows that, in the real world, an MTP inhibitor (lomitapide) could have serious liver issues.
Therapeutic agents that suppress apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) levels/activity are being developed in the clinic to benefit patients who are unable to reach target LDL-C levels with maximally tolerated lipid-lowering drugs. To compare and contrast the metabolic consequences of reducing these targets, murine-specific apoB or MTP antisense oligonucleotides (ASOs) were administered to chow-fed and high fat-fed C57BL/6 or to chow-fed and Western diet-fed LDLr(-/-) mice for periods ranging from 2 to 12 weeks, and detailed analyses of various factors affecting fatty acid metabolism were performed. Administration of these drugs significantly reduced target hepatic mRNA and protein, leading to similar reductions in hepatic VLDL/triglyceride secretion. MTP ASO treatment consistently led to increases in hepatic triglyceride accumulation and biomarkers of hepatotoxicity relative to apoB ASO due in part to enhanced expression of peroxisome proliferator activated receptor γ target genes and the inability to reduce hepatic fatty acid synthesis. Thus, although both drugs effectively lowered LDL-C levels in mice, the apoB ASO produced a more positive liver safety profile.
But Jet....think of all the diapers aegr can sell...let's see...4/per day x 365 days x $800/day (like their pills
Similar to dendreon's treatment price, this treatment price is wildly inflated. Unpleasant side effects will keep the patient population small. Maybe if this was priced $1200/yr (fair value) they might get 1000+ patients. dendreon investors were blinded by $ signs and look where they are now.
Sentiment: Strong Sell
Up until the most recent yahoo changes, i was able to extract out posts by author. For the moment, extraction by author isn't working worth a damn.
Some stocks on IV aren't very active, but others are. In my opinion, IV is worth the effort to learn. Here's a sample of the quality of some of the posts on IV. http://www.investorvillage.com/iv2/smbd.asp?mb=1373&mn=12427&pt=msg&mid=6472977 Now contrast that with the 95% garbage on yahoo.
I have an interest in WAMU, but not the spammers. I used to follow several stocks on the yahoo message boards, but not anymore.
When yahoo made some changes to their message boards about 3 yrs ago, I moved, with a bunch of other investors, to Investor Village. I don't miss the yahoo boards at all. The only reason i'm here is for the few good posters that are here.
No commissions, just sanity.
"In a way its hard to keep track of posts compare to yahoo."
Posts can be consolidated by topic.
Also, you can build links on your main page. Here's an example of a chart link I have: http://stockcharts.com/h-sc/ui?s=WAMUQ&p=D&b=4&g=0&id=p07530548511
To everyone fed up with yahoo message boards, Investor Village offers a more civilized message board.
Please consider joining the wamuq.pk message board
On Investor Village spammers and abusers do get banned.