they can spend a 1/2 million on you in a blink of an eye if you have paracentesis procedures and other complications ...(hepatopulmonary syndrome, portal hypertension, ammonia levels(encephalopathy) or ascites .just in test and procedures to get you on the liver transplant team and medical test to follow your meld score every week over a short time. Husband had blood disease to start with and one procedure finished off liver from Nash was not showing on test to cirrhosis than life was a total nightmare at hospitals every week.
I believe one of the clinicals might have been done at IU in Indianapolis also you can check this out.......more transplants done at IU in Indianapolis I believe I was told at one time they have a good team .
Amen....I agree you could have two successful winners.....peoples lives will be changed with the drugs for liver disease. No one can imagine what they go through unless you have journey down the road. Especially Ascites paracentesis procedures peritioneal cavity filling up from it and having a paracentesis every week or so...($8000) just to drain.. that was in 2012....( or where you live price may vary)...I am in Indiana...used Indianapolis Hospitals... 2 different hospitals .and transplant doctor at IU. The drug will be a miracle for these people if it stops any of this and makes life more comfortable. They can spend a 1/2 million on you in in a blink of an eye ....depending on your complications.
Also keep in mind some drugs work better on different people. Say both are successful... one drug might work better on some people, so having two good choices would even be better for the cirrhosis patients. The fact that Galt has a patent on the formula indicated it is a good potential and if it works well in other organs shows more of a natural I would analyze from other readings. Working to improve hypertension in the lungs gives us clues that it is most likely working in the liver well as the liver produces hormones that controls the lungs. That is why you have the complication of Hepatopulmonary Syndrone in cirrhosis. I know about Galt because I showed a doctor an article back in 2012 and he said they were watching them and this was a liver doctor. So pray for their success .....how many lives this drug will change. Only about 6000 transplant in the US done and they have to take expensive drugs the rest of their lives. If you have been through Cirrhosis (Nash) you would know all the complications and what this really means to liver disease. No Transplants. I was told by a liver transplant doctor there would be no transplants in 10 or 15 years and that was back in 2011.
Then it should help with the liver. The liver puts out hormones that contributes to Hepatopulmonary Syndrome. Hypoxemia is common in patients with end-stage liver disease, with a prevalence that has been reported to be as high as 45% of carefully evaluated patients. When patients awaiting liver transplantation are assessed,15%-30% have hepatopulmonary syndrome.[15,16]
The characteristics of hepatopulmonary syndrome include an oxygen saturation 15 mm Hg) while breathing room air, portal hypertension with or without cirrhosis, and dilation of intrapulmonary vessels.
Sentiment: Strong Buy
Ah....one has to wonder then....
why you waste your precious time on the message board.......hmm........not hard to comprehend the reason why.............................
Sentiment: Strong Buy
stock should be much higher........for the evidence they are showing....they should get their patent
Actually, if you know anything at all about the disease there is very little out there at this time that will help.....if this is actually doing what I read....it would be wonderfully....especially if the medication did not damage the liver.......which they are working on this also...fidelity carry the news also....on the financial under there symbol...for news...GALT
Galectin Therapeutics reports positive mid-stage data on psoriasis drug
— 6:17 PM ET 05/16/2016
May 16 (Reuters) - Galectin Therapeutics Inc ( GALT
* Drug infusions were well tolerated by patients
* Two adverse events were noted, one infiltration of intravenous catheter & one headache during infusion; were mild & transient
* Announces Positive Interim Results From Phase 2a Trial With Gr Md-02 in moderate-to-severe plaque psoriasis Source text for Eikon: Further company coverage:
This is why I know about GALT...... I woke up and remembered what it is called.... and this explains it better;however, GALT, would have a real win win situation......Most people have no idea all the complications of " Liver" disease and what it involves. My husband had a blood disease and a treatment given ...gave him cirrhosis because the test did not show he had NASH at the time. Sometimes NASH does not always show on the Liver test ...the Liver Transplant DR. told us ....and he had a reaction to the treatment. The hepatopulmonary syndrome results from the formation of microscopic intrapulmonary arteriovenous dilatations in patients with both chronic and acute liver failure. The mechanism is unknown but is thought to be due to increased liver production or decreased liver clearance of vasodilators, possibly involving nitric oxide.
The dilation of these blood vessels causes overperfusion relative to ventilation, leading to ventilation-perfusion mismatch and hypoxemia. There is an increased gradient between the partial pressure of oxygen in the alveoli of the lung and adjacent arteries (alveolar-arterial [A-a] gradient) while breathing room air. Additionally, late in cirrhosis, it is common to develop high output failure, which would lead to less time in capillaries per red blood cell, exacerbating the hypoxemia.
My husband had (pulmonary hypertension) secondary caused by the liver disease. Heart doctor explained the liver secretes hormones that help to control the lungs. His pressure could not be controlled enough for a liver transplant. They said he would not make it through the surgery(they tried nitric oxide to see if that would bridge him through the surgery, but it did not work). So, if this is caused by the liver hormones and the Galectin-3 helps the liver then it would also help the complications of Pulmonary hypertension or Portopulmonary hypertension I would think. Not to much out there that is safe for liver that helps the Pulmonary breathing......that works, so this would be great. I believe it all goes together so maybe that is why it helps and why they knew it would also....
), the leading developer of therapeutics that target galectin proteins to treat fibrosis and cancer, has received notification that its collaborative abstract with investigators at Augusta University “Galectin-3 Mediates Vascular Remodeling in Pulmonary Arterial Hypertension” has been accepted for presentation at the American Thoracic Society (ATS) 2016 International Conference, taking place May 13-18 in San Francisco.
The research was conducted in the laboratories of Drs. Scott Barman (Department of Pharmacology and Toxicology) and David Fulton (Vascular Biology Center) of Augusta University (AU), Augusta, GA. The abstract concludes with the hypothesis that galectin-3 is a central regulator of proliferation and fibrosis in pulmonary arterial hypertension and contributes to pathologic vascular remodeling in this disease. The authors are Scott Barman,Feng Chen, Yunchao Su, David W. Stepp, Jiliang Zhou, Louise Meadows, Yusi Wang, Xueyi Li, Stephen Haigh, Zsuzsanna Bordan, Peter G. Traber, Danny Jonigk, and David J.R. Fulton. The company’s lead compound GR-MD-02, one of the galectin-3 inhibitors used in this study, is currently the subject of Phase 2 studies in non-alcoholic steatohepatitis (NASH) and psoriasis.
“We are honored that the outstanding group of investigators at AU used our galectin inhibitor compounds, GR-MD-02 and GM-CT-01, in this important research and to have this research presented at the ATS 2016 International Conference,” said Peter G. Traber, M.D., chief executive officer and chief medical officer of Galectin Therapeutics ( GALT