Still holding, and really should of took the 2.50. A third primary miss will have us trading below a dollar. - Trvn - their Ph. II results from last Aug, I think the p-value was 0.0001. Their Ph III will hit stat sig. Imo, the best bio investment. GL - currently ~ $6.50
I've been researching and reading . .. and reading... and ...
" . .. Among the genes we found originally altered in patients with PCDH19-FE were the ARK1C genes, coding for enzymes involved in the production of neurosteroids allopregnanolone, estradiol and testosterone. Based on this research a small scale open label clinical trial using ganaxolone, a synthetic analog of allopregnanolone, has been designed by Marinus Pharmaceuticals Inc. (USA) and is currently (June 2015) ongoing
When yrs. of data are looked at, allo has proven efficacy/activity. Can ganax run with the big dogs (sage) ? I don't know but my bio experience tells me dealing with genes is extremely difficult. ps: hit primary we see 100%+ upside. [good way to close post : )
Nearly all the bios sold off today, -3%, -5%, -7%.. cept' us. +25% in two days. I'd like to believe tutes know. Unlike the last two trials, Ganax used as an adjuvant in FE, maybe that gets us the primary. GLTA
me (last week) and Sphera, , , ,,,, , buying.
Settlement Date Symbol Description Net Amount
7/6/2016 MRNS Bought 550 MRNS @ $1.2799 $710.95
The p.r. of last June sent Mrns. to a new high of twenty per share. With a similar MOA investors (tutes,etc.) saw this low cap stock and bought. If they hit primary this month with PPD we'll see some upside. Maybe. Their Ph II from start to finish less than one year.
As to our PCDH19 trial, Mrns p.r. 7/6/15 has - 'published data' - highlighted. Click that and then click - Full Text (pdf) - This abstract supports the reasoning for our Ph II trial. Excerpts below.
- Although we are yet to determine the underlying mechanism(s) of AKR1C gene
dysregulation in PCDH19-FE, we show that AKR1C gene downregulation leads to allopregnanolone
deficiency in the blood of all PCDH19-FE females tested so far
- Taken together, our findings on AKR1C gene dysregulation and subsequent allopregnanolone deficiency suggest that steroids and in particular neurosteroids (e.g. allopregnanolone) play an important role in PCDH19-FE and represent a realistic therapeutic target.
I have yet to study up on PPD, ... would like to find a paper supporting the use of GABAa agonist. I'm also trying to find evidence that our ganax will work in PCDH19 ..... nothing, Mrns had to of seen something ... .. .. .
MD's use the CGI-I - "The Clinical Global Impression – Improvement scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention" . ...
- primary endpoint.
Parents used the SNAP-IV questionnaire. - The Swanson, Nolan and Pelham Teacher and Parent Rating Scale (SNAP), . . .. is a 90-question self-report inventory designed to measure Attention Deficit Hyperactivity Disorder (ADHD) and Oppositional Defiant Disorder (ODD) symptoms in children and young adults.
- secondary endpoint.
tech, I'm with you on this. - - " the effect of Ganax on behavioural problems (re:FX, etc.) could be our best shot at . . . . an FDA approval." Safe and the parents like what they see. It will happen.
MRNS - 05:51:59
Bought 450s @ $1.50 - Total: $682.00
....... glutton for punishment . . .. (??)
hey.... laying on the couch....pc is off.... watching CNBC quotes running across bottom of screen.. Holy Moly ...MRNS $1.45 .... !!! Nice.... no guarantee market likes call, imo, Mrns has good news.
..what's that saying ... misery loves company (?) Lol ! I agree, overdue for some good news bio related... why can't it be FX - buyin tue too.
Bought 1100s @ $1.2599 - Total: $1,392.89
will re-read the 11 page pdf . . .. we have a shot.
I guess I'll hold..... if it's good news, me and everyone else got lucky. CNS science extremely difficult to call. JR, gltu ..... post here on occasion,,, maybe Mrns/Sage upcoming data surprises.
To prove beyond a shadow of a doubt that I am a bonafide psycho nut ...... might throw away (buy) 3k, new avg. of mid. 3, with potential of .3 end of July : (