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Momenta Pharmaceuticals Inc. Message Board

dr.vinmantoo 132 posts  |  Last Activity: Jul 20, 2016 1:44 PM Member since: May 18, 2010
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  • Reply to

    New to PGNX......

    by noonangf1225 May 20, 2016 2:22 PM
    dr.vinmantoo dr.vinmantoo May 23, 2016 5:17 PM Flag

    ""AN ANGRY LOOSER !!!.""

    What's a looser? That person wasn't looking for ideas. That person accurately said PGNX had no debt, so if they have cash it came from 1) some previous stock issuance (easily found), 2) milestone payment (easily found) or 3) Relistor sales (easily found).

  • Reply to

    New to PGNX......

    by noonangf1225 May 20, 2016 2:22 PM
    dr.vinmantoo dr.vinmantoo May 23, 2016 12:02 PM Flag

    telecominvest, right on the money. I love it when angry little ignorant trolls like this pssuoff emerge from their fetid sewer to emit their noxious odors then depart. It provides comic relief.

  • dr.vinmantoo dr.vinmantoo May 23, 2016 1:41 AM Flag

    Where is the article published?

  • dr.vinmantoo dr.vinmantoo May 23, 2016 1:40 AM Flag

    commonfodder, I wonder why the PPHM longs haven't flocked here to explain why my comment isn't accurate.

  • dr.vinmantoo dr.vinmantoo May 22, 2016 1:36 PM Flag

    Commonfodder, you are right on target as so many Bavi failures begins to paint a picture. It always shocks me how many people don't realize that cell line and mouse models are poor predictors of success in human clinical trials. You need to show efficacy there, but that is a very low bar compared to human trials. The basic mechanism of how Bavi acts provides clues to why it might not be effective, especially compared to the PD-1/PD-L1 disrupting approach.

  • Reply to

    New to PGNX......

    by noonangf1225 May 20, 2016 2:22 PM
    dr.vinmantoo dr.vinmantoo May 22, 2016 1:28 PM Flag

    You just noted that PGNX had no debt so why do you suggest a major loan agreement? How does a company build a cash reserve without debt? Surely you can figure that out.

  • Reply to

    Roche joins the party

    by coolhandlucy007_007 May 18, 2016 4:25 PM
    dr.vinmantoo dr.vinmantoo May 19, 2016 10:53 AM Flag

    Bavi has shown no efficacy as a single agent. Figure it out.

  • Reply to

    Roche joins the party

    by coolhandlucy007_007 May 18, 2016 4:25 PM
    dr.vinmantoo dr.vinmantoo May 18, 2016 10:54 PM Flag

    Why would BP need Bavi, a drug that has failed in every clinical trial to date?

  • Reply to

    Buying shares

    by jay_scott27 May 17, 2016 1:41 PM
    dr.vinmantoo dr.vinmantoo May 17, 2016 5:38 PM Flag

    There has been around 5 million total shares traded in a week. There is no way that spells a lot of accumulation.

  • dr.vinmantoo dr.vinmantoo May 12, 2016 12:40 AM Flag

    {{I do not claim to be extremely versed in medicine and realize there are many who are far superior to me in knowledge on at least the iHub not so much.}}

    I am glad you don't falsely claim to be extremely versed in medicine. There are NO experts on the IHub board. I like to read it and laugh as what the so called experts post. You made comment that you were 100% certain Bavi would succeed. That is funny too.

    {{As for your statement "What are you talking about? Did Bavi + chemo fail in mice like it failed in humans?", Bavi did not fail in humans. In every trial conducted it showed an improvement over the historical placebo arm...even the pancreatic trial showed some improvement, although it was not by a large factor. The trials may have not met their endpoints or show statistical significance, but they all showed some to flat out say Bavi failed is a bit misleading. }}

    I asked for any trial where Bavi showed statistically significant improvement. There are NONE. You can tout all the small improvements you like, but that won't cut it with the FDA, which I assume you are hoping PPHM can do. That spells failure to date.

    { As I said before, in time you will be proven wrong. You claim you are not wrong, but I believe you will be proven wrong in time.}}

    Nothing I said is wrong so there is nothing for me to be proven wrong. I said Bavi is a long shot but I wouldn't bet on it. I also said stranger things have happened.

    {{The scientific process doesn't always end after the first test...sometimes you need to run numerous tests and then it proves or disproves your hypothesis. I will wait. Less}}

    You don't understand the scientific process. Hypothesis, experiment, data collection then adjust hypothesis. Repeat. You don't prove anything. The hypothesis is partly consistent or fully consistent with the experimental parameters examined, or shown to be wrong.

  • dr.vinmantoo dr.vinmantoo May 12, 2016 12:25 AM Flag

    Jeff, I see why you coming to the wrong conclusions now.

    {{First, I have a BS in Civil Engineering, but also have the equivalent of two degrees in class units as I also enjoyed studying other sciences while in school. An engineer is a scientist in the sense that we study and utilize scientific principles in our work and even do scientific research.}}

    Engineering is a fine profession and it takes a lot of intelligence to be successful in it, but it is NOTHING like being a scientist doing biological research, Engineering is very precise because you know the strength of materials needed to build, the stresses likely to be encountered so that structures can be built to survive. All biological research is based on at best partial knowledge as there is so much we don't know. The discovery of microRNAs a few years ago and their important role in gene regulation, development and chromosome structure/function was totally unexpected. Moreover, cells are able to adapt to disruptions by using different compensatory pathways as well as to mutate/alter gene expression to overcome blocks to cell progression. No matter how much you know or think you know, any good scientist knows they must adjust their models as new data arises.

    {{What I mean by nature is that science is my life, I love the field and I absolutely love medicine. I wanted to be a medical doctor, but my first wife shot that down as she was selfish and thought it was more important to house and feed her and our two kids than spend 11 years through school and I was forced to choose a different field with 5 years as the time frame to complete my degree. I still enjoy medicine though and I read a lot to stay updated. }}

    I am glad you loved medicine, but being an MD wouldn't prepare you for scientific research. The training is very different. Your training in engineering is not only useless for doing or understanding biological research, it could be detrimental to your understanding.

  • dr.vinmantoo dr.vinmantoo May 11, 2016 12:13 PM Flag

    {{Wow- ducky is still here quacking - why??? What is the point? Go enjoy life a little and let it go.}}

    Ah, the typical pphm long response, insult others and avoid dealing with facts.

    I enjoy life each and everyday. I don't enjoy seeing people being sold a bunch of fantasies and long shots possibilities as sure fire investment successes.

  • dr.vinmantoo dr.vinmantoo May 11, 2016 2:02 AM Flag

    Jeff, I will continue.

    {{I am a scientist by training and by my I am not flying completely blind here.}}

    I have no idea what scientist by nature means. Just what exactly is your area of expertise, that is what area of science are you trained in, and what are you working on now? I am a research scientist in academia, and have been one for 30+ years. You will forgive me for being blunt but nothing you have posted remotely suggests you are a scientist by training. No scientist would ever declare that they have 100% faith in a combination treatment that has ZERO human clinical trial data, like you posted about Bavi plus immune modulators. I see nothing but blind faith in all your posts.

    {{I see a lot of promise...and yes I understand that it needs to be proven...why we do trials. I am in the camp that believes Bavi trials to date showed improvement and that all three major trials were not all flukes...or that shananagins were going on with the data.}}

    What three major trials are out were completed where Bavi showed efficacy? I am talking about rigorous trials that showed statistically significant improvement. I haven't seen any.

    {{And maybe the I/O combos are still to be proven}}

    Absolutely freaking correct.

    {{but Bavi in mouse chemo combo studies so far have correlated well in human clinical studies}}

    What are you talking about? Did Bavi + chemo fail in mice like it failed in humans?

    {{I have belief that they will do so with I/O as well. We will see. Hope they will partner soon to prove this....but it will not be overnight.}}

    Maybe so, but most likely not. There is a lot of competition and PPHM isn't exactly bargaining from a position of strength.

  • dr.vinmantoo dr.vinmantoo May 11, 2016 1:48 AM Flag


    {{Well DrV, everybody has their opinion.}}

    Yes, but not all opinions are equal. Some opinions are mere fantasies, like PPHM submitting a BLA based on Sunrise or Sunrise plus the corrupted phase II trial in NSCLC, whereas other opinions are based in reality.

    {{Although some of what you write may have merit, I do believe you are wrong with most and will eventually be proven to have been wrong. Not immediately, but in the coming months and years.And I am banking on it that you are wrong}}

    Nothing of what I said is wrong. Why don't you point out specifically where I am in error.

    {{Blind faith and all as you would likely believe I am basing my opinions on. I really do hope I am correct and you are wrong, not just because I make a few extra bucks, but because maybe there will be a lot of cancer patients that can get a little extra time, maybe for some a lot more time.}}

    Oh please, not the "for the sake of cancer patients out there" canard. Yes safe and effective cancer treatments are needed. However, but if something isn't effective, then it is best pushed by the wayside so money, and time can be better spent, and patients can move onto more promising treatments.

  • dr.vinmantoo dr.vinmantoo May 10, 2016 4:48 PM Flag

    {{I 100% believe Bavi will work well in I/O....but i also know they will need to partner to find out. }}

    Nobody knows if Bavi will work in I/O, yet you exude unshakeable confidence as shown by your comment that you 100% believe it will work. Faith is great but blind faith, especially in investing is the worst thing you can have.

    {{I originally wanted PPHM to partner with the Sunrise trial, but like many thought it was worth a shot to go it alone until they got past FDA approval.}}

    Any small company needs some kind of partnership for oncology. It is either a major sing of hubris or the fact that there are no interested takers when they try and go it alone.

    {{I know they will have to partner now....i think they know it as well. I am hopeful a partnership deal does happen this year....maybe it won't...but it is still way too early to throw in the towel.}}

    PPHM knows for sure they need to [partner, but they are in the worst position possible.

    {{And yes, with Avid, over $50 million in cash, and the Bavi and BB patents....yeah at 33 cents this is a buy.}}

    Bavi has failed in every single trial in combination with chemo and BBs are untested, but you think it is a good time to buy.

    {{It is ludicrous that our share price fell this low. Yes it will likely drop more with Russle rebalance and maybe even RS if that happens, but seriously those have already been baked in....any further SP decrease will be short lived.}}

    Actually, I am surprised the price hasn't fallen lower. If you think being removed from the Russel Index and the RS are already baked in, well you have big surprise coming. What invariably happens after an RS is the price declines significantly as the stock price become amenable to shorting.

    {{Eventually PPHM will rise again and with a partnership deal people will still have a great chance at a great return of investment...even those that have been in for a few years.}}

    Stranger things have happened but the odds are very long against it.

  • dr.vinmantoo dr.vinmantoo May 10, 2016 3:08 PM Flag

    Oh Jeff, you really are funny.

    {{This board is really just a bash fest, so I don't bother reading it as has gotten stale and boring with just a bunch of bashers having a jerk fest orgy. Since I am not into that nor agree with most of the #$%$ being spewed, I have lost a lot of my interest in this board.}}

    The truth is hard for some people to swallow so it is easier for people like you to just attack those telling you the truth than it is to accept reality.

    {{Sometime you just have to abandon the idiots and let them tend to themselves.}}

    That is what seems to have happened on Ihub as many of the usual pumpers have left. As far as idiots, are you referring to the morons who keep stating or even suggesting that PPHM will file a BLA and get Bavi approved based on a failed phase III? Or are you referring to those who say that the Sunrise data will be added to the corrupted compromised phase II trial with so many censored patients in the Bavi arm that they tried to hide it using low resolution images, and somehow get FDA approval? Or are you referring to the idiots who claim the FDA will allow approval of Bavi by letting PPHM discard the control arm to make Sunrise it a single arm trial, somehow forgetting that the trial was stopped at the first futility look?

    {{But, I do read every iHub board post though, at least there is balance there and thoughtful discussion....and a hell of a lot less personal attacks by lowbrow idiots. By the way, this is a great price to get back in...things can turn on a dime in this industry....and when it does, there usually is little warning.}}

    Wow, you actually posted that $0.33 is a good price to buy PPHM. Now that is funny, although I did notice you are down to "buy" instead of "strong buy" on your sentiment, so maybe there is hope for you after all.

  • Reply to

    Note to self:

    by learningcurve2020 May 10, 2016 8:56 AM
    dr.vinmantoo dr.vinmantoo May 10, 2016 12:29 PM Flag

    You have to be a complete idiot to think the go it alone strategy is/was viable.

  • dr.vinmantoo dr.vinmantoo May 10, 2016 12:27 PM Flag

    jeff, too bad you didn't take my advice about selling PPHM shares to lock in the tax loss and buying back. If you sold at $0.40 and bought back at $0.32 or $0.33 you could have had the same number of "valuable" PPHM shares and put some cash in your pocket to either spend on a vacation or to diversify your stock portfolio. Oh well, there is still plenty of time for to do that as PPHM will almost certainly drop more in the near future.

  • Reply to

    Frau Bleeker

    by antwan_rockamoora May 8, 2016 8:44 PM
    dr.vinmantoo dr.vinmantoo May 9, 2016 1:59 AM Flag

    Great Young Frankenstein reference.

  • Cloaked protector was once again spouting nonsense that PPHM could submit a BLA for Bavi based on the failed Sunrise trial. CorporalAgarn and Carboat are properly taking him to task.

    CorporalAgarn smacked CP with the following {{It is wrong. They are not going to file a BLA based on this failed trial. It really is as simple as that. You are waiting for them to specifically state this when there really is no need to do so. It is known.}}

    I joined into the fun with to try and explain how CP might have gotten to such a wrong conclusion.

    {{This is really a 2-part issue. First, PPHM is NOT going to file a BLA based on Sunrise or the small corrupted and now thoroughly discredited phase II Bavi+ DOC. Second, even if PPHM was dumb enough or desperate enough to file a BLA, the FDA would summarily reject it because it won't be based on any data from a completed trial, let alone successful trial. The only thing I can think of is that CP is using a mathematical principal to support his claim. A negative times a negative makes a positive. That is why he thinks PPHM will get FDA approval for Bavi.}}

    Apparently this is too much for the IHUB longs to bear, some humor to explain someone posting delusional fantasies about PPHM getting Bavi approved based on the failed Sunshine trial so my post was deleted. I contested the deletion.

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