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Amarin Corporation plc Message Board

gizmo_puppy95 105 posts  |  Last Activity: Jul 11, 2016 11:32 PM Member since: Feb 24, 2009
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  • gizmo_puppy95 gizmo_puppy95 Jul 11, 2016 11:32 PM Flag

    The problem was with PFS with STS --- a very difficult cancer to stop progression. They should of worked with the FDA to establish a "Non-Inferiority" Primary Objective along with Safety.
    The first trial and this trial do NOT correspond ... so I am seriously questioning the integrity of the first trial.
    It flat out failed as it was identical to doxo --- so the higher doxo obviously doesn't help with STS.
    Now this still has Lung and Glioblastoma trials, but also they did for one positive have double the "Clinical Benefit" up to this point, but the question is if they didn't have the amount of information they were supposed to, why not just wait till they did?
    I guess this was Enough to determine that Aldox just didn't add much benefit if any other than the responses.
    Once again: the first trial and this one do not correlate at all. The first was 6 months to 3.3 months which sure doesn't make sense here.
    The overall response rate or Tumor Reduction was nearly Double...so this could be a pathway to approval, but it should of been stated in the Primary Objective measurement. So the tumor Shrinkage was more in the Aldox group, but progression was unchanged vs soc.
    Also: Stable Disease of 4 months or more was double, but the fact that Median Progression was not is concerning, but they didn't give that much info on exactly how many were measured for sure, so the follow up will tell a lot more about Aldox.
    That said: I would of thought the PFS would have been longer --- BUT in STS I am NOT sure that this is the wisest choice to make because these tumors progress rapidly don't matter what when treated previously.
    DCR was also stat sig in the Aldox --- more partial responses and stable disease ... .0415 and this number should be lower at the next assessment.
    50% of the patients were excluded from PFS assessment --- that said --- once again still doesn't correlate with the first trial. Just doesn't make much sense

  • gizmo_puppy95 gizmo_puppy95 Jul 11, 2016 5:59 PM Flag

    If results were fine the stock would not be at .80 cents.

  • gizmo_puppy95 gizmo_puppy95 Jul 11, 2016 5:56 PM Flag

    This was Plenty of data to confirm that PFS is a FAIL. The ONLY path is if they follow all the way through for OS which will be 2017 at Earliest if not 2018.
    Just hope that Lung cancer is better. This will be a disaster for quite some time.

  • gizmo_puppy95 gizmo_puppy95 Jul 7, 2016 2:34 PM Flag

    Definitely could be right on this one. As much as I was hoping that CERU would come out on top, the control just may be a surprise.
    The price drop from 4.30 to 2.00 tells us that the confidence level in this stock is not high.
    I still believe this company has potential to become a good one, but it's too early to tell right now.
    As all biotechs --- this one is a gamble also.
    The technology appears very interesting but the set back of the trial more often than not is a negative which the price is reflecting.

  • Reply to

    Current LPCN market cap

    by staccani Jun 24, 2016 10:04 AM
    gizmo_puppy95 gizmo_puppy95 Jun 24, 2016 1:05 PM Flag

    Everyone and their predictions of counting their chicks before they hatch... be careful as this is not a "no brainer" and the Variance of levels along with fatty food diets could easily cause crl along with no lower doses along with the always unexpected that is overlooked.
    No Adcom doesn't mean approval either as some are speculating.

    Many are much more apt on the tests than I am comparing with the Gels --- I am still skeptical giving all the refusals of oral treatments.

  • gizmo_puppy95 gizmo_puppy95 Jun 15, 2016 6:44 PM Flag

    This is so usual for this stock. I expect it to test 2.22 that has been the holding point or breaking point in this one for quite some time (years) and 2.12 for the last catalyst with Aldox as they had total manipulation as if bad news had leaked and good news was announced, luckily I read the attack correctly. Not sure what is going on but I'm glad I sold and bought back when I did. If it breaks 2.22, it could quickly test 1.80's.
    2.22 is the Key point to watch. I also see a possible w being in the process of forming on chart, which would bring back above $3's.

  • gizmo_puppy95 gizmo_puppy95 Jun 15, 2016 12:56 PM Flag

    Me too buddy.
    IBS --- huge market if they can actually find something that Works. IRWD's drug causes too much diarrhea and SGYP - may be a little better.
    That said: SYN's new concept of gas being a major component just may lead to stat sig results which will of course open new doors.
    Always enjoy your comedy GP.

  • Reply to

    Clifton clinched it

    by gi197845 Jun 8, 2016 3:43 PM
    gizmo_puppy95 gizmo_puppy95 Jun 8, 2016 5:51 PM Flag

    Thanks for making me laugh...needed that!
    Now I'm going to cry!!

  • gizmo_puppy95 gizmo_puppy95 Jun 1, 2016 11:48 AM Flag

    That Mthrfckr. I had a some shares at 1.21, 5,000 shares. Sold out Way too early. Bought back at 10,00 and obviously sold way too quicklwy once again.
    That is the story of the year right there.

  • gizmo_puppy95 by gizmo_puppy95 May 31, 2016 12:23 AM Flag

    I think EVERYONE can Agree that is is OK to SHORT!
    The company hires worthless buffoons to do spin jobs to deceive the American Public.
    It is nothing more than a platform to manipulate.

    Sentiment: Strong Sell

  • Reply to

    Delisted by June

    by needmorewifi Mar 3, 2016 9:44 AM
    gizmo_puppy95 gizmo_puppy95 May 31, 2016 12:20 AM Flag

    People Enjoy Watching CLOWNS and that is Exactly what he is, a Freak Show.

  • Reply to

    Philly Dope

    by lee122oneill May 29, 2016 9:32 AM
    gizmo_puppy95 gizmo_puppy95 May 30, 2016 11:40 PM Flag

    Now that is freaking sad. Just horrible and represents everything what America Shouldn't be.

  • Reply to

    Thanks to Trump, My Decision in the Fall is Done

    by bitesr May 27, 2016 2:41 PM
    gizmo_puppy95 gizmo_puppy95 May 29, 2016 4:10 PM Flag

    Bitesr --- as much as we disagree on CTIX and I admittedly was wrong as I was hoping that this trial would be the ONE to lead to the next one being the approval trial (still could be - wait and see), Very Disappointed in the stock price right now --- I do agree with you on this lobbying B.S.,
    Storage is Unquestionably the Future. We are now to the point in which Solar can work a lot better than it did 10 years ago, but storing it is the problem -- same with wind.
    I'm glad you are working on something that I personally would Love to see innovation in and makes Common Sense.
    Have you looked into Thorium at all?
    Getting people to change will take time and they do pay off for non-innovation which is very disturbing.
    Keep me posted on progress.

  • gizmo_puppy95 gizmo_puppy95 May 29, 2016 3:35 PM Flag

    The weekly Stochastics on the TVIX is nearing a bottom ... very close in my opinion and that to me has worked very well in Stocks, not sure about a manipulated index.
    I appreciate your post on yield curve.
    One my Q: What ticker or tickers do you use to compute or do you have your own software of variables? I have never actually looked at a yield curve chart so I do not know what to even type in to look for.
    Thanks Mi904.

  • gizmo_puppy95 by gizmo_puppy95 May 29, 2016 3:30 PM Flag

    by CS. Just as JPM Chase have the Silver Market Completely Rigged and have been buying it since 2011 but Shorting it to keep it low.
    The question is: Will they Allow it to even Run?
    Technically is sure appears to be Oversold but it wouldn't be the first time it has been oversold only for a 6% pop and then shorted heavily again.
    The entire market has been Artificially Held up and the question is how long can they do this until eventually the Dollar just Crashes?
    Investing has become 100% Corrupt on All levels.
    It is so EASY making Money by Shorting these days...It's EZ Money.
    But the Bubble is becoming very large and I can see the S&P and DJIA crashing possibly this year -- if not this year I don't see how they can continue to print Fiat Cash to buy up Treasuries.
    Even though Gold has had a great run this year... it is still being held down and there is HEAVY Accumulation and the same goes for Silver. Sooner or later something has to give.

  • gizmo_puppy95 gizmo_puppy95 May 29, 2016 2:57 PM Flag

    What specific chart are you referring to?

  • Reply to

    Thanks to Trump, My Decision in the Fall is Done

    by bitesr May 27, 2016 2:41 PM
    gizmo_puppy95 gizmo_puppy95 May 28, 2016 11:33 PM Flag

    It BLOWS me away at how STUPID our Voting Class is. It's like they listen completely to the media and do not do their own research.
    C'mon people at least do your own research and Learn to Spell! Jeeeessssh.
    All the Uneducated, Clueless and those who are Easily Brainwashed will vote for Hillary or Sander.
    NO Socialist has EVER done ANY Good.
    You people have to understand that there is no such thing as FREE.
    If you raise the minimum wages, everyone else will raise their prices so in the End you end up Losing Bigger than you already are.
    Socialism will completely Destroy this country and bring it Down.
    If Hillary is indicted and Bernie actually Wins ... we are seriously Screwed because there will be NO repairing the damage he has done.
    Obama has spend almost $15 Trillion in his 8 years. This is about Triple the money of ALL the Previous Presidents have spent from 1700's until the idiot took office.
    Bernie would put the Final Nail in the Coffin that Obama has built.
    Our military needs to be rebuilt because Obama has destroyed it.
    Man, our entire country is a mess and the Financial Markets are being artificially held up. The Crash of 2016 could be coming soon.

  • Reply to

    Thanks to Trump, My Decision in the Fall is Done

    by bitesr May 27, 2016 2:41 PM
    gizmo_puppy95 gizmo_puppy95 May 28, 2016 11:23 PM Flag

    God have mercy on the bottom of our Feet? What?
    NZ Germany is what is occurring right now.
    I haven't heard Trump speak hate about anyone except those that Hate America.

  • Reply to

    Thanks to Trump, My Decision in the Fall is Done

    by bitesr May 27, 2016 2:41 PM
    gizmo_puppy95 gizmo_puppy95 May 28, 2016 11:21 PM Flag

    I will Agree with you Whole Heartedly that we need to be able to STORE it. That is the FUTURE Technology and if someone actually can figure this out that would be game changing.

  • Reply to

    Thanks to Trump, My Decision in the Fall is Done

    by bitesr May 27, 2016 2:41 PM
    gizmo_puppy95 gizmo_puppy95 May 28, 2016 11:14 PM Flag

    You are being Selfish thinking for yourself and not the people as a whole. You are the part of the problem. To vote for a person who would end your life if you "Accidentally" saw something or knew something ... well go for it.
    Trump is for Cheaper Renewable Energy. He hinted their is still a lot of work to do to get the prices lower and more affordable. He will be in full support if it truly is for the better of society. Solar is still too expensive but I bought my panels for about 1.50 a watt but they need to get it well under a buck. Wind energy is ok in the right areas but still way too expensive.
    There are a Ton of new Energy options, it is just a matter of slowly integrating them as most oil companies were caught with their pants down by not diversifying and being innovative.
    Tesla is doing a good job on their batteries, just a ton of energy options that are just now beginning to scratch the surface.
    All politicians in this country are bought to go along with the Elites plan of maintaining control. Trump is not one of them, Clinton is the ideal Protocol and would do Anything for Money.
    Why do you think Bernie and Trump are getting so much attention. People are sick of the average corrupt politicians.
    Trump will attempt to bring jobs back in the U.S. but it won't be easy working with all the idiots.
    Our Economy is HORRIBLE. Clinton is not going to do anything to help it and a lot of this is her stupid molesting husband. Yes, the economy was good, but it wasn't due to Clinton's policies...they don't take effect until 4 to 8 years later and when they did Businesses began moving out of the country.
    We haven't had a decent President since Ronny.

AMRN
2.39Jul 28 4:00 PMEDT