Yes, and shorter too. We are arguing apple and orange. You are saying no paper on neuvax showing antibodies response to HER2. I am saying an antibody response to the peptide, nonspecific , not recognizing the HER2 protein. I don't think you can generate an antibody response to a specific peptide using GMCSF is all I am saying.
Also. a couple of months prior, I asked Remy if ALL the patients have been screened for immuno-competency and the answer from the investigator was yes, all of them.
In all my 25 years of using peptides for immunization I have never had any peptide, long or short, which did not induce antibodies.
I wrote to Remy a couple of days earlier about performing antibodies test on the 70 recurrent patients and she replied she will pass the idea on to the investigators. It is very simple to do such a test and the antibodies only need to recognize the immunizing peptide by elisa , not the HER2 protein per se. It can be done in less than a day should the blood be available.
Lool at the bright side. Now everyone and their mother become aware of GALE's Neucax.
Moreover, if the IDMC does not think a reversal of the reversed data will yield a different outcome and recommendation why would they bother to ask for an investigation ?
I suspect there is a subset of patients the data of which is reversed by mistake (or intentionally after receiving a bribe from a shorty). It won't be hard to figure out by a simple antibodiy test. The antibodies do not even have to be able to detect HER2. All that is needed is an eisa test against Neuvax the peptide. A few hours work is all it take to find out who gets what treatment and if she has recurrent disease. .
I have discussed this with Remy and she promised to communicate the idea to the investigators.