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Vertex Pharmaceuticals Incorporated Message Board

thirdmeinvestor 1 post  |  Last Activity: Jul 10, 2016 12:58 PM Member since: Feb 25, 2004
  • Reply to

    mrna technology

    by qdelfan Jul 6, 2016 10:23 AM
    thirdmeinvestor thirdmeinvestor Jul 10, 2016 12:58 PM Flag

    Both technologies are very very new and have hope and dreams the technology potential can offer. Both, in my and others' opinion, have tremendous challenges to overcome before they can be translated into medicine. This does not mean that there won't be some successes in applications of the technologies in future. Both technologies have to deliver RNA bits into the cells without being degraded by endonucleases. Moderna's potential drugs have to cross the cell membrane to be translated into proteins inside the cells. The latter has to occur in human body, not in vitro setting. There are great deal of claims than proofs. Moderna has a large number of patents to backup their claim that their chemistry can overcome nuclease degradation. I would like to see the proof of this happening in the human body. I have yet to find a clinical trial in which the goal is to create a new protein in the human body.

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