Recent

% | $
Quotes you view appear here for quick access.

Insmed Incorporated Message Board

underdogs14 9 posts  |  Last Activity: Jun 28, 2016 6:12 PM Member since: Aug 10, 2007
SortNewest  |  Oldest  |  Highest Rated Expand all messages
  • Reply to

    BIZARRE EMA?

    by underdogs14 Jun 28, 2016 6:07 PM
    underdogs14 underdogs14 Jun 28, 2016 6:12 PM Flag

    Maybe the current FDA phase lll trial using only MAC patients converting at say 70% will convince them? Amazing.

    Sentiment: Buy

  • underdogs14 by underdogs14 Jun 28, 2016 6:07 PM Flag

    The EMEA was not prepared to recommend approval, since there was not enough evidence that Arikayce can 'permanently' clear the bactueria from the sputum (what drug can even convert?), and thus the “benefits of Arikayce did not outewiegh its risks” (what risks?)

    So 30% safe,culture conversion on drug within 6 months and 80% of those still converted and safe after 1 year of non use while no drug has been approved for a lethal disease is not good enough for a The EMA? Just BIZARRE

    http://www.ema.europa.eu/docs/en_GB/document_library/Medicine_QA/2016/06/WC500209287.pdf

    Sentiment: Buy

  • Reply to

    New patent/Platinum cancer treatment

    by underdogs14 Jun 23, 2016 10:43 AM
    underdogs14 underdogs14 Jun 23, 2016 10:49 AM Flag

    The Eleison license doesn’t pertain to liposomal cisplatin for injection into the body cavity, targeting cancers beyond the lung; hence the new patent application.

    Sentiment: Buy

  • Reply to

    New patent/Platinum cancer treatment

    by underdogs14 Jun 23, 2016 10:43 AM
    underdogs14 underdogs14 Jun 23, 2016 10:46 AM Flag

    Insmed previously granted Eleison a license to develop liposomal cisplatin for inhalation:

    Inhaled Lipid-complexed Cisplatin (ILC)

    Eleison has an exclusive worldwide license to ILC, a novel, sustained release formulation of cisplatin in a nanoscale lipid based complex administered via inhalation, in development for pediatric osteosarcoma (OS) - bone cancer. ILC was designed to deliver high levels of sustained release cisplatin targeted to the lung, without systemic-related toxicities. ILC has been evaluated in 89 patients in four clinical studies, with evidence of efficacy in several cancer types including lung and bronchoalveolar.

    In pediatric OS, approximately 35% of patients fail first-line therapy, mostly with metastatic recurrence only in the lungs, and with poor prognosis (five year survival of such patients is

  • New patent application filed last week.
    Platinum for cancer treatment, encased in liposomes, and injected into the body cavity to bypass the gastric tract.

    Abstract
    One aspect of the invention relates to methods of treating cancer in a patient comprising administering intraperitoneally to a patient in need thereof a cancer treating effective amount of a composition comprising a lipid-complexed platinum compound wherein the concentration of the platinum compound of the lipid-complexed platinum compound composition is greater than about 1.2 mg/ml. Another aspect of the invention relates to lipid-complexed platinum compound compositions where the concentration of the platinum compound is greater than about 1.2 mg/ml.

    Sentiment: Buy

  • underdogs14 underdogs14 Jun 20, 2016 10:11 AM Flag

    Good points pianoman. Credit to Hound-dog..,

    At clinical trials.gov, a study conducted by University of Miami and University of Florida:

    “To determine the prevalence of nontuberculous mycobacterial infection (NTM) in pediatric patients with cystic fibrosis in the State of Florida. HYPOTHESIS: There is high prevalence of NTM in CF pediatric population in the State of Florida, and likely higher than in the rest of the country.”

    Sponsor:
    University of Miami
    Collaborator:
    University of Florida
    Information provided by (Responsible Party):
    Andrew Colin, University of Miami

    Study completed; results not yet posted.

    https://clinicaltrials.gov/ct2/show/NCT02198079?term=ntm&rank=6

    Sentiment: Buy

  • Reply to

    Strange??

    by underdogs14 Jun 11, 2016 6:43 PM
    underdogs14 underdogs14 Jun 14, 2016 11:01 AM Flag

    Insmed may be closer to FDA approval than anyone realizes.

  • underdogs14 by underdogs14 Jun 11, 2016 6:43 PM Flag

    Somethings in the works..,
    Next week’s COMP meeting:

    4.2. Orphan designated products for discussion prior to adoption of CHMP opinion

    4.2.3. - amikacin –EMA/OD/024/06, EU/3/06/387, EMEA/H/C/003936
    Insmed Limited;
    a) Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis (EMA/OD/024/06, EU/3/06/387)
    b) Treatment of nontuberculous mycobacterial lung disease (EMA/OD/191/13, EU/3/14/1259)
    Action: For discussion
    Document(s) tabled:
    Draft report on review of OMPD

    If they weren’t in line for a Conditional Approval - - if the CHMP was going to reject them outright, why would this be on the COMP Agenda?
    Also why the reference to CF?

    Sentiment: Strong Buy

  • underdogs14 underdogs14 Jun 2, 2016 11:04 AM Flag

    Going way higher.., indeed

    Sentiment: Strong Buy

INSM
12.95-0.32(-2.41%)Aug 31 4:00 PMEDT