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whippersnapper65 549 posts  |  Last Activity: Jul 18, 2016 2:13 PM Member since: Jun 20, 2009
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  • Everything that MLK accomplished to improve relations between whites and blacks and to save the nation from a race war has been thoroughly undone by Obama and the Democrat Party over the past six years.

    MLK would be a conservative if he were still alive, and he would be terribly ashamed of the Democrat Party and would rebuke Democrats for their policies and rhetoric.

  • Reply to

    Ziopharma effect?

    by dpemco Jul 16, 2016 2:26 PM
    whippersnapper65 whippersnapper65 Jul 16, 2016 4:43 PM Flag

    Why would it? After ACT IV's failure solely because of the anomalously outperforming control group Celldex management has not even hinted at a pathway for Rintega's approval. Perhaps management has been having ongoing discussions with the FDA (available because of Rintega's breakthrough therapy designation) that would permit a BLA to be filed based on noninferiority of Rintega to Temozolomide in newly diagnosed patients and on superiority of Rintega+Avastin to Avastin alone in relapsed patients. That would seem to be a reasonable pursuit, given the accumulated evidence and the desperate need of GBM patients. Perhaps management has uncovered something in the ACT IV data that explains the control group's anomalous performance. We don't know because the company hasn't announced anything like that. The only thing that will move the company's share price upward significantly is news about a pathway for Rintega's approval, or Glemba efficacy or Varli efficacy.

    Sentiment: Strong Buy

  • whippersnapper65 whippersnapper65 Jul 16, 2016 1:15 PM Flag

    It would be good for the company to host a CC in conjunction with the 2Q financial filing.

    Sentiment: Strong Buy

  • whippersnapper65 whippersnapper65 Jul 13, 2016 4:42 PM Flag

    Tibor Keler provided that update during his talk on Tuesday.

    Sentiment: Strong Buy

  • Reply to

    CDX-014

    by tina_astoria Jul 11, 2016 4:14 PM
    whippersnapper65 whippersnapper65 Jul 11, 2016 5:35 PM Flag

    You and Tina are two of the few people whom I have not placed on ignore on this board.

    Sentiment: Strong Buy

  • whippersnapper65 whippersnapper65 Jul 9, 2016 6:49 PM Flag

    Black lives in their mothers' wombs don't matter to the Left. Black babies are aborted at a rate far in excess of the black percentage of the American population. If black lives mattered to the Left, abortion would be outlawed.

    Black lives taken by other blacks in the streets of Chicago and Baltimore don't matter to the Left. Black on Black homicide is increasing as policing has become lax in response to criticism, legal jeopardy, and ambushes. If black lives mattered to the Left, the Left would be the police's number one supporters and their activity to apprehend criminals and prevent crimes in heavily black areas would be lauded.

    Black lives don't matter to the Left. The farcical, anarchist movement "Black Lives Matter" is what matters to the Left because the movement is politically useful for creating racial tension, stoking fear, and provoking heinous behavior that is then blamed on all sorts of things other than the Leftist politicians who fomented it.

    Black lives don't actually matter to the Left; "Black Lives Matter" is all that matters to them. Eventually it will be the next politically useful fabricated social movement that matters, and "Black Lives Matter" will have been forgotten. Black lives have already been forgotten by the Left; that happened long ago.

  • Reply to

    Each time...

    by raysfrom98 Jul 9, 2016 1:29 PM
    whippersnapper65 whippersnapper65 Jul 9, 2016 3:56 PM Flag

    President Obama either doesn't get it or he gets it better than his followers know.

    He's not dumb, so he gets it better than his followers know: he knows that what he says isn't true, but he also knows that the falsehoods he repeats are politically useful for him and his party because his followers believe what he says is true.

    So much of what BHO wants to do has been advanced on the basis of lies. Think about blaming Benghazi on the YouTube video. Absurd on its face, but it was useful and served its purpose.

    BHO's followers are the dumb ones. They don't realize how they're being played and used. And among those followers the blacks are the dumbest; not for racist reasons, which I know I'll be accused of, but for reasons having to do with not realizing that BHO doesn't care about blacks as individuals, only as a group that can be manipulated for poltical purposes. Blacks who don't realize the Democrats have been using them for fifty years, after which they are now worse off than before, are dumb. Democrats intentionally keep blacks down in order to keep them as reliable Democrat voters. As soon as blacks rely on themselves and take responsibility for themselves instead of relying on the government and blaming whites, they turn conservative. And what the Democrat Party has done to blacks for fifty years it is now attempting to do with Hispanics: manipulate them and keep them on the Democrat plantation.

  • Reply to

    Statistics

    by francogarabaldi Jul 8, 2016 12:29 PM
    whippersnapper65 whippersnapper65 Jul 8, 2016 2:39 PM Flag

    Hate and racism overwhelmingly come from the Left, but they have been successful in casting those aspersions unfairly on Conservatives.

    Why is the Left's hateful rhetoric against police not being identified as the "root cause" of the assassinations of the police officers?

    Obama has been an utter catastrophe for America.

  • whippersnapper65 whippersnapper65 Jul 8, 2016 12:35 PM Flag

    More fundamental insight: the Left is evil.
    Corollary: the Left destroys; it doesn't build.
    2nd Corollary: no wise or virtuous person would be on the Left.
    3rd Corollary: the Left must be opposed and defeated if civilization is to be free and prosperous.

  • Reply to

    The Board and Bored

    by invest83838 Jul 7, 2016 6:27 PM
    whippersnapper65 whippersnapper65 Jul 7, 2016 10:30 PM Flag

    America doesn't exist anymore. This country isn't the USA. It's not the country of Washington, Hamilton or Jefferson. It's not the country that was brought into existence through the Declaration of Independence and the Constitution. It's an imposter nation, a leftist tyranny posing as a constitutional republic.

  • whippersnapper65 whippersnapper65 Jul 7, 2016 10:27 PM Flag

    It will amount to nothing: just a blah, blah overview of the pipeline. Don't expect anything about ACT IV's review.

    The only important thing about this is that at least the executives aren't in hiding anymore after ACT IV's failure, although it's only Tibor Keler giving the interview, not Marucci or Davis.

    Sentiment: Strong Buy

  • Reply to

    Glemba in SCC of the lung now recruiting

    by btchinvstr Apr 21, 2016 3:06 AM
    whippersnapper65 whippersnapper65 Jul 3, 2016 10:11 PM Flag

    Recall that a month ago or so Celldex released a PR saying that it had entered into an equity sales agreement with Cantor Fitzgerald to sell up to $60 million worth of shares. That would be the stop-gap funding source to which you refer, which Celldex may exercise if needed.

    The company has stated that it has funds to last through the first half of 2018. The equity sales agreement could extend that to the end of 2018.

    There will be readouts in varli trials over the next twelve months. If those show efficacy, then the share price ought to rise readily because of the extremely high value proposition that varli represents and the possibility that Celldex could partner varli, if need be, in order to raise funds.

    Management is hiring an executive VP of global regulatory affairs (top management level), so they must be confident about 1) success, 2) remaining independent and 3) attracting a qualified candidate based on the undisclosed company or trial information they currently have.

    Sentiment: Strong Buy

  • Reply to

    Glemba in SCC of the lung now recruiting

    by btchinvstr Apr 21, 2016 3:06 AM
    whippersnapper65 whippersnapper65 Jul 3, 2016 5:47 PM Flag

    carlrich, I asked IR about the METRIC trial and was told that management is blind to the trial data, that the goal is to complete enrollment by the end of this year, and that the primary outcome measure of PFS would be expected about six months after the trial had fully enrolled. The company would announce the overall result but would wait to share the trial data at an appropriate scientific or medical conference.

    Management has not communicated anything about a DSMB monitoring the trial nor about specified interim looks nor about early stops for success or futility.

    In short, we will probably not hear much of anything about METRIC for the rest of this year besides whether enrollment is keeping pace with the goal of reaching full enrollment by year's end.

    The only other glemba news we can expect this year comes from a statement made in the 1Q earnings report:

    "Patient enrollment is complete in the Phase 2 single-agent study of glembatumumab vedotin in metastatic melanoma. The Company is currently amending the protocol to add a second cohort of patients to a glembatumumab vedotin and varlilumab combination arm to assess the potential clinical benefit of the combination and to explore varlilumab's potential biologic and immunologic effect when combined with an ADC. The Company expects to present data from the single-agent cohort at an appropriate medical meeting in the second half of 2016."

    Maybe data from that trial will provide some insight into how effective glemba is as an ADC in killing gpNMB-expressing tumor cells. The decision to expand testing in conjunction with varli is probably positive.

    Sentiment: Strong Buy

  • Reply to

    Good For The British People

    by j20tower20 Jun 24, 2016 10:31 AM
    whippersnapper65 whippersnapper65 Jun 24, 2016 11:41 AM Flag

    I would hope that if the Supreme Court gets stacked with leftists who commit jurisprudential malfeasance by rendering decisions that are routinely unmoored to Constitutional principles and the Constitution itself as written and originally intended, there will be a convention of states as per Article Five to reassert the right of the people not to live under the tyranny of a federal government. That would be America's last hope.

  • Reply to

    Good For The British People

    by j20tower20 Jun 24, 2016 10:31 AM
    whippersnapper65 whippersnapper65 Jun 24, 2016 10:59 AM Flag

    Polling data show that older people, who remember what Britain was like (meaning better) when it was independent, carried the "leave" vote over the top. Foolish and ignorant millennials who don't know how socialism ruins a nation, economy and society, voted overwhelmingly to stay in the union.

    Millennials and unassimilated immigrants will be the ruination of America, as they have begun to ruin Britain. It's already happening. That's been the Democrat plan for at least a decade. There may be hope for Britain, but the jury's still out about America.

  • whippersnapper65 whippersnapper65 Jun 21, 2016 5:18 PM Flag

    re:"The pivotal TNBC trial is open label so CLDX is aware of results as the trial progresses- "

    I asked IR about this: whether management has knowledge of open-label METRIC patient responses as the trial progresses. I was told that management is blind to the METRIC data.

    I'm not sure how that can be since the trial is open-label, but I didn't ask for clarification since my original question had been extremely clear.

    Sentiment: Strong Buy

  • whippersnapper65 whippersnapper65 Jun 21, 2016 2:17 AM Flag

    Is it reasonable to conclude that changing the primary outcome wording to specify the possibility of a complete response being observed means that some complete responses, among other responses, have been observed and the investigators are finding it necessary to distinguish types of disease control so that a more precise description of Glemba's efficacy can be provided at the study's end?

    Surely you don't begin an investigational study with a protocol that calls for measuring complete response rates out of fear that there might be none. I think adding the new wording and shortening the length of time for the study are both very positive indications.

    Let's hope that Glemba's targeting of gpNMB is proving effective and will be comparably effective in the METRIC breast cancer study and in the melanoma study.

    Smart bombs targeted at cancer cells: wave of the future.

    Sentiment: Strong Buy

  • Reply to

    MBB On Ignore Along with A Few Other

    by j20tower20 Jun 20, 2016 11:12 AM
    whippersnapper65 whippersnapper65 Jun 20, 2016 12:42 PM Flag

    I ignored those sheetheads a long, long time ago.

  • Reply to

    QA admin position

    by btchinvstr Jun 17, 2016 5:30 PM
    whippersnapper65 whippersnapper65 Jun 17, 2016 8:28 PM Flag

    Yes, I would like to know what "pre-BLA approval" referred to in the job description.

    A phase 2 glemba trial in advanced melanoma patients is scheduled for primary data collection next month, according to clinical trials gov.

    I would also like to know why management is now seeking a "top executive" SVP of global regulatory affairs. Unless there are indications that a treatment will be approvable in less than a year, it seems premature to be seeking that sort of candidate.

    Sentiment: Strong Buy

  • Reply to

    Merck's Keytruda Results this Morning

    by maximus06906 Jun 16, 2016 2:25 PM
    whippersnapper65 whippersnapper65 Jun 16, 2016 2:39 PM Flag

    No, but there is a combination trial with Roche's Atezolizumab, which targets PD-L1, like Keytruda.

    Sentiment: Strong Buy

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