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Exelixis, Inc. Message Board

wilderguide 266 posts  |  Last Activity: 2 hours 31 minutes ago Member since: Jan 13, 2011
  • Reply to

    Third Quarter Reflections

    by biotrader922 Sep 30, 2016 2:39 PM
    wilderguide wilderguide 2 hours 31 minutes ago Flag

    $$$$
    "Third qtr was a complete bust."
    Fifth patient conversion was announced 8/17...
    Will you also consider it a "complete bust" as conversions #6, #7, & #8 are announced?
    You'd best go back to pudd-pounding...something you might someday get good at...
    Cuz yer skills at value assertion are going Nowheresville...

  • wilderguide wilderguide Sep 30, 2016 2:18 PM Flag

    $$$$
    "Are you aware of any progress made to date by the company regarding the use of CT imaging monitoring?"
    None has been published (to the best of my knowledge), but it wouldn't surprise me to find that NVIV has contacted CT-imaging thought leaders for guidance. For my money, that'd be Dan Haber at MGH...Peter Kuehn at Scripps...or Jon Goldin at MedQIA. It would appear MRI has failed at providing best information on SC trauma assessments in the preoperative NSS implant setting. This could prove problematic, as these types of advanced CT-imaging platforms are not always available at trauma centers, and patient risk may be exacerbated by the rigors of transport. Patient benefit stands to be compromised with increased transport exposure. It's a current conundrum...though I suspect resolution is at hand. Enhanced imaging platforms have made tremendous strides in recent years - just a matter of fine-tuning to specific needs and reads. All JMO...

  • wilderguide wilderguide Sep 29, 2016 8:36 PM Flag

    $$$$
    "...one of them appeared to be asleep..."
    That'd be me...that's how I appear while focusing on hard data...
    Here's what you'll find upon publication, review, and addition to the NVIV corporate presentation: Smiles all around. Tissue sparing, inflammation, white matter propagation are conditions all mitigated by NSS implant. Inconsistent to the cause is interpretive MRI validation, so I expect we'll see an advanced CT imaging program - perhaps custom-designed - to best monitor the post-operative healing process. The neuro-permissive, axon-perpetuating microenvironment stands a hair-width from clinical validation. Stay ready...
    Doc Fehlings is a creature of publication habit. Give him a week or two...

  • Reply to

    Cervical study

    by loose_cargo Sep 27, 2016 1:30 PM
    wilderguide wilderguide Sep 27, 2016 7:04 PM Flag

    $$$$
    "Cervical trial to go ahead by end of Q3..."
    Probably the result of meetings with CNS steering committee that are taking place this week.
    Beginning quite soon now, I suspect we'll see a series of PRs that will prove productive. GLTA

  • Reply to

    Conference next week

    by voisybay Sep 23, 2016 6:01 AM
    wilderguide wilderguide Sep 24, 2016 1:49 PM Flag

    $$$$
    $8 You promise...?"
    I may not always be the best at reading the tea leaves, but I understand the significance of oral presentation in a prestigious venue. Here, we have two...
    In medicine, typical acceptance of late-breaking oral presentation is determined by potential that stands to offer practice-changing data. If those data are well-received in a peer-reviewed setting such as CNS, the analysts will respond with new price targets before the week is out. If a sixth AIS grade conversion were to be announced at this venue, the SP could spike dramatically on healthy volume. The institutions haven't been accumulating for naught. Timing is everything. Stay ready.

  • Reply to

    Conference next week

    by voisybay Sep 23, 2016 6:01 AM
    wilderguide wilderguide Sep 23, 2016 5:55 PM Flag

    $$$$
    "Maybe Canada's FDA equilavent approved the NSS."
    While I think that thought a bit premature, here's what I see taking place next week...
    A case for probable benefit of NSS implant is slowly being built, and further - being supported by early witness to minimum OPC thresholds. The scrutiny for the remainder of enrollment will be the target of clinical largess - if only to safeguard preservation of existing data. Further changes to protocol may be required to best inform, and will be made to best align with validated observations of advanced imaging - a continually improving aspect of this procedure. I expect NVIV to paint the tape in the vicinity of $8 next week...with CNS 2016 data being interpreted as a huge success. All JMO...

  • wilderguide wilderguide Sep 23, 2016 2:39 PM Flag

    $$$$
    "I can't wait to learn more about those "secret" canadian patients you've been pumping."
    How else could a Health Canada-licensed neurosurgeon report on his personal surgical experience with the NSS?

    "Can I ask what value YOU bring to this board?"
    Humor. I'll keeping pumping company "secrets"...
    While you keep pumping yer pudd...

  • wilderguide wilderguide Sep 22, 2016 5:31 PM Flag

    $$$$
    Thanks for sharing your wisdom...
    Think I'll get out now, just before the NSS has two LBA oral abstracts...
    Given by independent neurosurgical reviewers...
    At one of the most prestigious neurosurgical conferences of the year...
    Thanks for saving my butt... I owe you my life...really...
    Whew!!! ....that was close...

  • wilderguide wilderguide Sep 20, 2016 11:12 AM Flag

    $$$$
    "I would say "yes" wilder. One need not be Sherlock to deduce that Canada has not only performed the procedure on one or more patient, but has enjoyed success."
    Further to this, the LBA submission deadline was 8/2/16. The Health Canada ITA was awarded on 7/13, with the first ex-US location announcement on 7/14 - making it a reasonable assumption that the first Canadian NSS patient is nearly two months into recovery - perhaps giving us a 6 month evaluation timeline before Feb 2017.
    Make no mistake, the CNS would make a great venue to announce another early conversion.

  • $$$$
    ...means there is at least one Canadian SCI recruited to the INSPIRE trial, doesn't it?
    No worries...moving right along...

  • wilderguide wilderguide Sep 20, 2016 6:50 AM Flag

    $$$$
    "in the end, most are making a mountain out of a molehill. Very good results to date..."
    I agree. There seems to be a lot of impatience with the process of peer review. Many here are too willing to hold Perrin accountable for clinical development issues that are beyond his scope as CEO. The neurosurgical community must carry the ball here as their independent review is the only review that will carry the weight of scientific validation. Further, that validation comes with specific protocols of venue and presentation. No researcher wants his work interpreted prematurely, and no researcher wants his work unveiled at any but the most appropriate venue. That's simply how it's done, and that schedule of appropriate peer-reviewed scientific presentation is completely independent of CEO concerns, trial process, or shareholder wishes. There's lots at play here that is beyond Perrin's control, if only because it's beyond his professional capacity.
    Just the way it is...

  • Reply to

    Inspire Clinical Trials Link

    by options2wealth Sep 18, 2016 11:44 AM
    wilderguide wilderguide Sep 18, 2016 4:32 PM Flag

    $$$$
    "Doesn't mean they weren't "paused"...
    Yer brain is permanently "paused"...
    You are a cubicle monkey with three speeds, biotrader: Slow, Stop & Stupid

  • wilderguide wilderguide Sep 14, 2016 6:58 PM Flag

    $$$$
    JMO, but I don't think we've accumulated enough data to add to the site-specific trial protocol, but given that OPC minimum threshold has been met this early in the trial structure, it is a possibility. If a major change to trial protocol had been applied for by NVIV, it would certainly account for the recruiting shutdown - if one has indeed taken place.

  • $$$$
    When I first posted this abstract several weeks ago, it was ha-ha'ed by Thrope as "old news"...
    Well - guess what, you moping, loping, groping dope with no hope to cope...
    These surgical big dogs don't think it's "old news"...
    Stay ready, dooshwaddle...

  • wilderguide wilderguide Aug 27, 2016 12:20 PM Flag

    $$$$
    "Essentially three months left in the year..."
    Yeah, lecture us on truth, you math wizard. There are four months remaining in the year, and truth is - each one ends in "R" : this indicates a month in which "Recruitment" likelihood is optimal. Now there's a great truth for you...
    Get off your sorry brain, go outside, and find a life...

  • wilderguide wilderguide Aug 27, 2016 12:02 PM Flag

    $$$$
    Sun Tsu says:
    Those that dispel their perceived truths on Yahoo Message Boards...
    Have no idea what truth is...

  • Reply to

    Hillary killing the entire sector

    by creedheed Aug 24, 2016 3:36 PM
    wilderguide wilderguide Aug 24, 2016 5:54 PM Flag

    $$$$
    Speaking of stuff that don't work, how's the kids? Mom & Pop OK?

  • Reply to

    Director picks up 70,000 shares

    by balmoral_design Aug 24, 2016 9:58 AM
    wilderguide wilderguide Aug 24, 2016 10:26 AM Flag

    $$$$
    "...a little poke in the eye..."
    Just like a bad penny, a zit, or a cold sore...
    You keep coming back... What's yer problem?
    Need a fresh Dydee?

  • Reply to

    Vroom! Vroom!!

    by wilderguide Aug 22, 2016 3:01 PM
    wilderguide wilderguide Aug 22, 2016 3:59 PM Flag

    $$$$
    "Anybody walking?"
    Not a trial endpoint...
    "Anybody moving?"
    Some more than others...
    Stick to the published trial endpoints, and you'll better understand what happens next...
    My questions to you - Anybody converting - as defined by AIS criteria?
    Seen any peer reviewed publications noting a high AIS conversion rate wrt INSPIRE?
    See any notable institutions participating in INSPIRE? See anything at all...???
    Other than the lack of light in yer patootie?
    Need a snorkel?

  • wilderguide by wilderguide Aug 22, 2016 3:01 PM Flag

    $$$$
    Somebody musta stolen the front spoke balloons outta Thrope's BMX...

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