I think that the biggest reason as to why (as someone else said) they changed max to 48 hours instead of 36 hours, and why they mixed MultiStem with tPA, is because they couldn't get enough volunteers. The trial completion was postponed one or two times, and their PR about the completion was pretty much at the last possible moment without another postponement.
Okay, so avimoraxsdoc's post is not totally wrong, but it is misleading. Yes, there were fewer deaths and yes, this statement: "However, MultiStem treatment was associated with lower rates of mortality and life threatening adverse events (AEs), infections and pulmonary events" gives one reason to hope, but avimoraxsdoc did not quite get his wording right.
I don't want to shove anything into anyone, I just want the information to be correct as possible.
Mindless down-thumbers, here is Athersys's OWN PRESS RELEASE:
"With respect to the primary and secondary endpoints, the cell therapy did not show a difference at 90 days compared to placebo."
Check out the information compiled on Wikipedia about it -- "However, there was an excess of mortality in treated patients in the first week after the event, mostly from intracranial haemorrhage". This means you can do the MultiStem treatment at 24 hours and it should still provide a benefit, ASSUMING IT DOES -- BECAUSE WE DON'T REALLY KNOW SINCE ATHERSYS WON'T PROVIDE RAW PATIENT DATA.
No, this is wrong. ALL Multistem patients (in aggregate) had no better outcome than placebo on primary and secondary endpoints.
"A prominent meta-analysis of these trials concluded that rtPA given within 6 hours of a stroke significantly increased the odds of being alive and independent at final follow-up, particularly in patients treated within 3 hours. However, there was an excess of mortality in treated patients in the first week after the event, mostly from intracranial haemorrhage"
It's possible that MultiStem reduces or removes tPA problem, but it's simply pure speculation at present.
Please elaborate... no mention about any of this in the release.
I don't know. Oil companies are very responsive to cost issues. If oil goes up it is not too difficult to put the rigs back up.
Looks like CYTR is giving it all back now.... where is VCEL traded? It surely isn't US stock markets, or Yahoo is messing up again.
Maybe the initial post was worded poorly. Maybe the OP knows something about the presentation we don't. But so far, I'm not seeing it...
(Would you like to elaborate? Is there some stuff from the presentation yesterday we are missing here? I don't see any information about it anywhere.)