BMRN EU patient is on Gene sequence. US disallows discovery as invention. US SRPT argument with BMRN seems to be they claim they own all exon 51 sites by discovery only.
"Australia court rules against breast cancer gene patent". BBC online NEWS. In short a Discovery of a gene sequence or marker is not patent-able. It is naturally occurring and was not invented, just discovery alone is not.
Leslie Hudson CEO was bad, in at $3.60 a share. Since management keeps getting better. $37 today. Just a ten bagger. Lets go for just only a simple, #$%$ thirty bagger with this BAD team, Please.
Shocker!!!! It was the FDA that asked for Natural history data. Hoffman the Twitz and and McDonald's UC Davis mixed data confused the natural history data by lumping it into ALL DMD.
So against 51 data Eteplirsen stands out great. I expect this same type of natural history data to will expose lower DATA results in the other less quick to onset exons. Will that be the next Exon 53,or 43 or 8 Data shocker for shorts,? I can read the headline now, "SRPT less effective" shows data not as effective for other exons as was for EXON 51. (because of natural history being different).
In short, SO with DMD nature history all forms of DMD WILL HAVE DIFFERENT DATA SETS. Shocker!!!!
PS SRPT had to find this out itself since all the money raised an spent by DMD Charities and drug company no one had published a simple study on the natural history of different DMD forms.
1. Jean-Paul served as the President and CEO of Sanofi Pasteur MSD, the leading EU in Multiple Sclerosis, Oncology & Immunology.
2. Steve Wilton and new research deal with UWA with new MS targets. (Auto immune diseases).
3. Makes perfect sense...
This was about trial design. Thank Hoffman for the delay and questioning of the reports and trail design. He shot SRPT to promote his own Company, slime-ball Mr "No Conflict of Interest"..
AF=Aegore Frankenstein, , Villagers get your torches and pitchforks. Burn his Castle down....
As a growth stock, I would want to see a break even or debt rising with new trials, acquisitions and mergers with similar technology. I'd rather see dirty fur on the back of SRPT not a shinny penny.
Well Phil Reames the great investment manager. Big on BMRN.. Blow hard...FB
Point here is we follow the Toxic effects, this is under reported. Just because they can get away with under reporting should they. They glossed over Sticks as a minor problem.
I think its major if only it causes kids to be terrified of the treatment. Enough to stop treatment by the Family and by the MD ordering such treatments. Thing is they didn't have to send them to a Hospital, just home treatments.
DO you see that anywhere? It may have been MD or Nursing (undocumented) orders. I guarantee someone was following those skin reactions for infection, tissue necrosis and healing.
Thanks Neo but I have started more IV's, given more Injections than I could ever count. I little kid will go ballistic with any pain. They go ballistic with just the idea of a needle. Its traumatizing. With Shots I never get a reaction from the shot, the Drugs That's another thing.
They would have reported pain and keep an eye on the site. With reported problem, there pain, and plenty of it. Treated somehow with hot packs, numbing meds or something., but not listed as needing treatment or causing pain.
I noticed on the BMRN drisp side adverse effects was many injection site reactions, however no documentation for PAIN at injection site? Or listed separate ? Pain is listed as zero.
How could you have injection site reactions with no (Zero 0) pain at that site? Pain was miss reported in the trial. Zero pain outside of the injection site only was reported? No Pain listed under injection site reported, it's assumed? They continue miss report trial results on Pain. My concern is this, It seems they are reporting injection site reactions but no pain scale documentation in their list of reactions. . . or separated it out. it's a misdirection with reported data.
I would have listed injection site pain as PAIN on a scale of 1-10. EU Medical and Nursing may not use the same Pain reporting as in the US as part of Vital signs.
PS please follow up..
mdwhitier, I noticed on the BMRN side adverse effects was many injection site reactions, however no documentation for PAIN at injection site? Pain is listed as zero. How could you have injection site reactions with no pain at that site? Pain was miss reported in the trial. Zero pain outside of the injection site only was reported? No Pain listed under injection site reported, it's assumed? They continue miss report trial results on Pain.
PS he was probably in a bar drinking "Craft beer", with this guy. That short guy caught the tab.