This makes alot of sense, to be honest with you I have no idea why they are even considering dilution when the drug is completely un encumbered both in the u.s. and in e.u and has a run rate of 300m in u.s. and has the potential of doing another 300 in eu.
I had my shoulder done 3 years ago and I must say that was the most painful experience I had ever had. The pain started as soon as I got home when the intervenus stuff wore off. I had to sit in a chair with a pillow beneath my arm to separate the Arm from the body and stabalize its movement (I found this out talking with another guy who had this done after I got home) and any movement would sent me to pain convulsions. I sat there all night and the pain medications were not working at all and my wife called the doctor and they said I already had the best stuff on the market as far as pain killers go and I had to just take it like a man. I wish this drug was out then.
Anyone who has hemorrhoid surgery should insist on having zohydro for the 4 weeks after surgery, because the pain is excruciating and throbbing at the contractions. I know this because I had this surgery.
Summarizing data from three different surveillance systems, there were an estimated 56,000 emergency room visits, 26,000 hospitalizations, and 458 deaths related to acetaminophen-associated overdoses PER YEAR during the 1990-1998 period.
Acetaminophen overdoses can be very serious
By Herb Weisbaum Aug 13, 2014
Just because you can buy a medication without a prescription, doesn't mean it can't hurt you.
Almost 80,000 people wind up in a hospital emergency room each year because they took too much acetaminophen, the active ingredient in Tylenol.
"It's very safe up to just about 4,000mg a day," said Lisa Gill with Consumer Reports Best Buy Drugs. "As you start to creep over 4,000, you start to get into a very risky area, and it doesn't take a whole lot of extra acetaminophen to get you into the danger zone."
Gill says acetaminophen is now the most common cause of liver failure in this country.
You shouldn't drink alcohol if you're taking products with acetaminophen, and you need to be careful about other medications that contain the drug. That's a common way of overdosing.
"Acetaminophen shows up in more than 600 products, both products that you get without a prescription, just on the pharmacy shelf, and products that you get with a prescription," Gill told me.
It's especially common in combination cough-and-cold and allergy relief medications.
To me the most painful times was trying to move and take another pain killer every 4 hours. Any contraction of my muscles in my rectum caused a positive feedback--pain causing more contraction and more pain.
Yes sorry about that. One glaring fact that is often not mentioned about the 80k overdose emergency room cases is that 63% of those involved Vicodin drugs. Zogenics cited this studyMichna, E, Duh, MS, Korves, C, Dahl, JL. Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications. Pain Medicine. 2010; 11: 369-378.
I wonder why do these politicians want to poison the patient who need these drugs and destroy their livers and cardiovascular systems? There have always been those who are psychologically dependent on drugs, if not this drug it will be something else, and even in those cases, why destroy their hearts and livers, do these politicians really think that a drug addict thinks oh yes if I take too much of this it will destroy my liver or my heart? These are the same politicians who despite the parents protests pass condoms in high schools because they are going it to do it any way so why not be safe. Why not apply the same logic to these drugs?
The first night I remember sitting in my chair holding my arm in steady position looking at the clock to see when it is time for my next dose per my doctor's prescription. I had already taken triple the dosage of oxicodone, when the pain started, and in the conversation with my the doctor he warned me of liver damage if I take more than what the prescription says. There was no sleeping in the cards for me the first night at all and I welcomed daylight just because I had passed the night. The sever pain lasted for 2 weeks and the doctor sent me to rehab on the third day and had me move my arm even though every movement caused excruciating pain. Beyond that the sever pain persisted for 3 months, and moderate pain after that for the first year. When they fix your shoulder the pull the tenants and tighten them so the shoulder socket is really tight and there is not enough lubricant in the joint to facilitation motion so every motion is painful. The range of motion is also limited so as you extend beyond the range of motion, whether accidentally or on purpose you experience excruciating pain. In my opinion, every doctor who does shoulder surgery should have the 20mg Zohydro option available for their patients.