During my mothers visit I had an opportunity to speak to the Orthopedic surgeon involved in the study. I asked him what precipitated his involvement in the drug study, he quickly corrected me and reiterated it is a biologic and not a drug. (Somebody please tell me the difference.) He explained that many of his patients prefer to try conservative treatment before surgery. He was honest in acknowledging Hyaluronic acid is ineffective but patients are willing to try it regardless of its inability to alleviate pain or provide sustain relief. He said people in general would like to avoid surgery if possible. He went on to state he has limited options and not many alternatives to surgery and is looking for an alternative.to Nsaids , Ibuprofen and Steroids. . He said steroids provide temporary re leaf however they have been shown to adversely effect the knee joint and cause destruction of the bone. He believes the application for the Ampion is far greater for tendons and ligaments where steroids really compromise the strength of soft tissue and possibly induce ruptures of the ligaments. I have never witnessed a doctor so exited about the possibilities of potential applications. It was somewhat confounding because I thought they earned there living operating . It gave me a different appreciation for surgeons.
I have a family member whom is very furtunate to have had access, to the enrollment of the Ampion spring study. My mother was originally diagnosed with early stage osteoarthritis ,and has subsequently progressed to the pt. where she is a candidate for a total knee replacement. She is reluctant and averse to surgery for fear of the potential complications. She has tried all of the conservative modalities of treatment ,steriod injections and multiple series of Hyaluronic Acid. The results have been ineffective and somewhat dubious at best. As we all know, the manifestation of pain is a subjective phenomenon and tolerance is uniquely individual. However, daily funtions and activities are the real measure of sucess and can be demonstrated. She reached the treshhold where her pain was debilitating. She finally conceded and succumb to the reality of her joint replacement, until she heard a local radio advertisement advertising the spring study. She wanted to try one more conservative treatment so she enrolled. She just concluded her twelve week follow-up which I attended, so I could inquire more information about the study. Her pain has significantly decreased and her activity has significantly increased. She is not sure if she recieved the placebo or the saline, its difficult for me to imagine saline would provide such relief. She feels she received a miracle drug. I can"t wait for them to reveal what she recieved. I asked the P.A. if her results are abnormal ,she said she could not discuss specifics but they are not. So all I can say is "many times we make assumptions although logically sound are based on insufficient info. and often lead to erroneous conclusions." It is compelling enough to buy stock, I hope she received ampion and not saline!!