or would the history repeat itself and we go through this whole fiasco again. The point is they seem very lacking in experience and expertise in doing anything other than drug development and clinical trials. They also seem to have no desire to find a good partner which could have avoided this incredible stupidity in the place. Yes i understand they want to go it alone and own all the profit; but the problem is they may be actually making less money for taking so long to submit NDA. The clock is ticking on the patent expiration. Assuming they get the approval, how would they educate doctors, market and distribute the drugs without a major partner? How are they going to make billions without a partner? I think the management and culture of ACAD have to change drastically to be successful. ACAD needs a F1 race team of CEO and management to make things happen. A team that focuses on what it would take to do NDA, manufacturing, marketing, and distribution successfully (i.e. partnership). I already advised my wife who has signficant long-term ACAD investment to sell and get back in when the company can regain our trust.