"On the flip side, we note there is a section with numerous drugs 'contra-indicated' due to interactions with ritonavir booster, but this seems relatively niche (less than 10-15%) of the population while GILD has no contra-indications," Yee added.
Yee, like many analysts, believes Gilead will retain 80% of the market, which could be good for as much as $15 billion next year. That still leaves around $3 billion for AbbVie.
Most analysts had assumed that AbbVie will gain that share by providing a modest discount to the $94,500 for 12 weeks of Harvoni. AbbVie ultimately will charge 12% less, though 8-week Harvoni patients pay less.
Some drug providers, notably Express Scripts (NASDAQ:ESRX) and CVS Health (NYSE:CVS), have been hoping to start a price war to drive down HCV treatment costs. But Yee points out that AbbVie is already working on a next-generation, all-genotype treatment and has an interest in keeping prices high.
The State Department's Rose Gottemoeller, under secretary for arms control and international security, spoke at the Brookings Institution Thursday where she reaffirmed the United States' "unassailable" commitment to putting the nuclear weapons genie back in the bottle. Gottemoeller told the attendees at the Arms Control and Non-Proliferation Initiative-sponsored event that "the U.S. commitment to achieving the peace and security of a world without nuclear weapons is unassailable."
She went on to note that the nation's stockpile of active weapons is down 85 percent from maximum cold war levels, falling to 4,804 in 2013 from a high of 31,255. But, she said, "We still have more work to do."
North Korea dispatched covert commando teams to the United States in the 1990s to attack nuclear power plants and major cities in a conflict, according to a declassified Defense Intelligence Agency report.
The DIA report, dated Sept. 13, 2004, reveals that five units of covert commandos were trained for the attacks inside the country.
According to the report, the “Reconnaissance Bureau, North Korea, had agents in place to attack American nuclear power plants.”
The document states that the North Korean Ministry of People’s Armed Forces, the ministry in charge of the military, “established five liaison offices in the early 1990s, to train and infiltrate operatives into the United States to attack nuclear power plants and major cities in case of hostilities.”
“One of the driving forces behind the establishment of the units and infiltration of operatives was the slow progress in developing a multi-stage ballistic missile.”
North Korea is known to have at least two long-range missiles capable of hitting the United States, the Taepodong-2 intercontinental ballistic missile, and the KN-08 road-mobile ICBM, which has not yet been flight tested.
The report indicates that power plants would be targeted for attack “in the event of hostilities between the United States and DPRK” – the acronym for the Democratic People’s Republic of North Korea.
December 18, 2014 5:00 am
China carried out a long-range missile flight test on Saturday using multiple, independently targetable reentry vehicles, or MIRVs, according to U.S. defense officials.
The flight test Saturday of a new DF-41 missile, China’s longest-range intercontinental ballistic missile, marks the first test of multiple warhead capabilities for China, officials told the Washington Free Beacon.
China has been known to be developing multiple-warhead technology, which it obtained from the United States illegally in the 1990s.
However, the Dec. 13 DF-41 flight test, using an unknown number of inert maneuvering warheads, is being viewed by U.S. intelligence agencies as a significant advance for China’s strategic nuclear forces and part of a build-up that is likely to affect the strategic balance of forces.
China’s nuclear arsenal is estimated to include around 240 very large warheads. That number is expected to increase sharply as the Chinese deploy new multiple-warhead missiles.
The current deployed U.S. strategic warhead arsenal includes 1,642 warheads. All 450 Minuteman III missiles have been modified to no longer carry MIRVs. However, Trident II submarine-launched missiles can carry up to 14 MIRVs per missile.
Additionally, the development of China’s multiple warhead technology was assisted by illegal transfers of technology from U.S. companies during the Clinton administration, according to documents and officials familiar with the issue.
Good point. I've been planning to hit the exit before the Fed raised rates, but they keep pushing that back.
AGNC also has no foreign exposure to trouble-spots like Russia China the Mideast, or the EU.
12%is a good rate of return.
Russia just raised their key interest rate from 10% to 17%. Any Russian REIT is dead.
The Iran Nuclear Talks Were Successful -- For Iran
It seems like Iran has the upper hand in the negotiations with world leaders over its nuclear program. First, the talks failed to bring a deal by the Nov. 24 deadline. During the negotiations, the Iranian diplomats shouted at Secretary of State John Kerry so violently that his bodyguards thought the "negotiations" would go beyond words. But as the talks failed, the countries at the table agreed to move the deadline to June 30. And according to Kerry, a former peace protester, diplomats will be joining hands, singing Kum Ba Ya within a few months time. But that's not what Iran has been indicating. It has shopped for materials to build a heavy-water reactor that could make weapons-grade plutonium. And while the U.S. announced Iran made concessions, Iran publicly corrected the White House. Iranian President Hassan Rouhani told his state-run media, "Of course we bypass sanctions. We are proud that we bypass sanctions because the sanctions are illegal." By these indications, it seems like Kerry can add the Iranian nuclear talks as a smashing failure to his résumé.
U.S. employers added the largest number of workers in nearly three years in October and wages increased, which could bring the Federal Reserve closer to raising interest rates. Nonfarm payrolls surged by 321,000 last month, the most since January of 2012, the Labor Department said on Friday. The unemployment rate held steady at a six-year low of 5.8 percent.
Data for September and October were revised to show 44,000 more jobs created than previously reported.
Economists polled by Reuters had forecast payrolls increasing by only 230,000 last month.
November marked the 10th straight month that job growth has exceeded 200,000, the longest stretch since 1994, and further confirmed the economy is weathering slowdowns in China and the euro zone, as well as a recession in Japan.
Just one month after Harry Reid lost HIS job, things are starting to look up!
Economist Brett Arends:
It just happened — and almost nobody noticed.
The International Monetary Fund recently released the latest numbers for the world economy. And when you measure national economic output in “real” terms of goods and services, China will this year produce $17.6 trillion — compared with $17.4 trillion for the U.S.A.
As recently as 2000, we produced nearly three times as much as the Chinese.
To put the numbers slightly differently, China now accounts for 16.5% of the global economy when measured in real purchasing-power terms, compared with 16.3% for the U.S.
This latest economic earthquake follows the development last year when China surpassed the U.S. for the first time in terms of global trade.
I first reported on this looming development over two years ago, but the moment came sooner than I or anyone else had predicted. China’s recent decision to bring gross domestic product calculations in line with international standards has revealed activity that had previously gone uncounted.
These calculations are based on a well-established and widely used economic measure known as purchasing-power parity (or PPP), which measures the actual output as opposed to fluctuations in exchange rates. So a Starbucks venti Frappucino served in Beijing counts the same as a venti Frappucino served in Minneapolis, regardless of what happens to be going on among foreign-exchange traders.
PPP is the real way of comparing economies. It is one reported by the IMF and was, for example, the one used by McKinsey & Co. consultants back in the 1990s when they undertook a study of economic productivity on behalf of the British government.
2 more years of declines should be expected thanks to our current Dear Leader.
How many other people bought over $50 and are just itching to sell?
I should buy more at this price but I can't force myself to pull the trigger.
I bought SOXL instead.
We have multiple Phase 2 efforts going on in Hepatitis B a disease that affects over 400 million people worldwide and this is a particularly exciting area for R&D organizations as we attempt to discover a cure and address this huge unmet medical need. We’re also exploring Simtuzumab which is a monoclonal antibody and SYK fibrotic diseases such -- as well as in oncology. And it’s a very interesting compound and we should start to see our first 48 days a week readout in the second half of next year.
Leading analog semiconductor manufacturer Avago Technologies Limited (AVGO) recorded strong fourth-quarter fiscal 2014 results (ended Nov 2, 2014) with substantial year-over-year improvements in revenue and recurring earnings on the back of accretive LSI Corporation and PLX Technology Inc. acquisitions. This is the first full quarter in which Avago and PLX operated as a combined entity after the $309 million acquisition successfully closed in August this year. Avago completed the acquisition of LSI in May 2014 and this is the second quarter in which its earnings are included in the former’s results.
Sanders brags that he is a Socialist who believes the Government should control the means of distribution. He doesn't believe in property rights.
Inexpensive Hep-C Treatment
Aethlon Medical, Inc. (AEMD), the pioneer in developing targeted therapeutic devices to address infectious disease and cancer, today reported final clinical outcomes, including rapid virologic response (RVR) and sustained virologic response (SVR) rates, in Hepatitis-C virus (HCV) infected individuals who received Hemopurifier® therapy during a clinical study conducted at the Medanta Medicity Institute in India. Aethlon is now preparing to launch its first human clinical studies in the United States.
The Aethlon Hemopurifier® is a first-in-class bio-filtration device that targets the rapid elimination of viruses and immunosuppressive proteins from the circulatory system of infected individuals. The device is a leading broad-spectrum treatment countermeasure against viral pathogens that are not treatable with drug or vaccine therapies. In HCV care, the device is positioned to address antiviral drug resistance and hard-to-treat patients who are unable to tolerate normally administered doses of antiviral drugs or peginterferon+ribavirin (PR) therapy. It is estimated that approximately 170 million people worldwide are infected with HCV, which leads to chronic liver disease or cirrhosis, and is a leading cause of liver transplantation.
In the study, HCV-infected individuals were enrolled to receive three six-hour Hemopurifier® treatments during the first three days of a 48-week peginterferon+ribavirin (PR) treatment regimen. Aethlon reported that Hemopurifier® therapy was well tolerated and without device-related adverse events in twelve treated patients. Of these twelve patients, ten completed the Hemopurifier-PR treatment protocol, including eight genotype-1 patients and two genotype-3 patients. Eight of the ten patients (n=8/10) achieved a sustained virologic response (SVR), which is the clinical definition of treatment cure and is defined as undetectable HCV RNA 24-weeks after the completion of the 48-week PR drug r
The airlines industry is poised for strong growth in the near future. In the recently concluded third quarter of 2014, most airlines companies posted solid numbers despite the Ebola outbreak and unfavorable economic conditions. Improved momentum on the freight side and the downtrend in oil prices coupled with increased demand for passenger traffic provide the tailwind for the industry.
As per the World Tourism Organization (:UNWTO), in the first eight months of 2014, foreign tourist arrivals rose 5% globally as compared with the same period in 2013. For full-year 2014, they are expected to grow between 4% and 4% annually. This is likely to act as a long-term positive for the airline industry.
Iran on Monday unveiled new missiles, torpedoes, and warships just a week after nuclear negotiations between Tehran and the West broke apart with little headway made between the sides.
The new military hardware was widely publicized by Iranian military leaders following an order by Supreme Leader Ali Khamanei urging the country’s armed forces to step up their combat readiness despite an extension in nuclear talks with the West.
The Iranian Navy displayed a crop of new vessels equipped with cruise missiles and other rockets. Also unveiled were new attack helicopters “equipped with Iran’s latest home-grown torpedoes,” according to Iranian military leaders quoted by the country’s state-controlled press.
The show of force is likely meant to send a message to the United States and other Western nations following another failed round of talks over Iran’s contested nuclear weapons program.
I suspect they intend to take full advantage of Obama's final two years.
I sold Dec05 $75 strike call options against my shares when the stock was under $75. Then it popped to $79. I thought I would lose my shares.
There was a report that Thanksgiving weekend sales were down 11%, but today is Cyber Monday and when they report good sales numbers I expect GoPro to get back in gear.
If it stays below $75 for the rest of the week, that would be ideal for me because I keep my stock and I keep the premium I got for selling the calls.
While Russia's nuclear bombers have recently set the West abuzz by probing NATO's air defenses, a far more certain danger currently lurks beneath the frigid Arctic waters off Russia's northern coast — a toxic boneyard for Soviet nuclear ships and reactors whose containment systems are gradually wearing out.
Left to decay at the bottom of the ocean, the world is facing a worst case scenario described as "an Arctic underwater Chernobyl, played out in slow motion," according to Thomas Nilsen, an editor at the Barents Observer newspaper and a member of a Norwegian watchdog group that monitors the situation.
According to a joint Russian-Norwegian report issued in 2012, there are 17,000 containers of nuclear waste, 19 rusting Soviet nuclear ships and 14 nuclear reactors cut out of atomic vessels at the bottom of the Kara Sea.
When the Soviets first began dumping the spent nuclear fuel, the disposal method was standard practice across the globe.
"Most nuclear states had similar practices before the early 1970s," including the U.S. navy, Dr. Eugene Miasnikov, head of the Moscow-based Center for Arms Control, Energy and Environmental studies told The Moscow Times.
But while other nations abandoned the practice of dumping radioactive waste at sea, the Soviet Union continued to do so until its collapse in 1991, and did so in larger volumes than other nuclear powers.
Dr. Nils Bohmer, the managing director of the Bellona Foundation — a prominent Norwegian environmental NGO that works Arctic nuclear waste issues — explains this discrepancy by the fact that the Soviet navy experienced significantly more nuclear incidents than anyone else.
Some of the thousands of containers have already shown signs of leakage, according to Nilsen of the Barents Observer.
Oil is a world market. Looking at OPEC, the two most anti-American members Iran and Venezuela, need to sell oil at $100 a bbl or their governments will collapse. In Russia, Putin is staring at another great depression and the ruble is plummeting.
We are doing well in spite of Obama and will do better starting in January.
I don't know if LEU would benefit from this, although the economy would:
President Barack Obama would veto an emerging $450 billion tax cut deal coming together in the Senate because it doesn’t do enough for the middle class, according to the White House.
“The President would veto the proposed deal because it would provide permanent tax breaks to help well-connected corporations while neglecting working families,” said Jen Friedman, deputy White House press secretary.
The emerging package of tax cuts negotiated by top Democrats and Republicans would extend an array of mostly business tax breaks — some permanently — while some of the president’s priorities would be left on the cutting room floor.
The package includes the research and development break and is expected to revive a slew of other provisions that benefit corporate interests, including NASCAR, film producers and the owners of racehorses.
The so-called “tax extenders” package has been in the works for months, after most of the provisions expired in January. Democrats negotiated to add some of their preferred tax cuts, including a tax subsidy for mass transit and the deductibility of sales taxes, but other provisions, like an enhanced Earned Income Tax Credit, would expire.
The roughly $450 billion pricetag over a decade would add to the deficit. Outside deficit watchdogs warn that would effectively change the baseline for any future tax reform.
The fresh veto threat ups the ante from yesterday, when Press Secretary Josh Earnest said the president would not support a corporate tax cut package that did not help the middle class.
With the backing of senior Senate Democrats, it’s conceivable the Senate could have the votes to override a veto on a tax cut package. In that case, House Minority Leader Nancy Pelosi, D-Calif., could end up being the presidential veto backstop, if it comes to that.