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bbandassoc 1101 posts  |  Last Activity: 19 hours ago Member since: May 31, 2011
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  • Very nice presentation by Dr. Crooke. Obviously, nothing new, but the take-away to me was they will be materially changing their financial forecast for NOL and year-end cash balance for the better at the upcoming Q2 earnings release. And, there are a lot of other milestones for the 2H15 to help the stock. Certainly, the early data for various applications was extremely impressive. I was also impressed with the acknowledgement that they have figured out how to use antisense technology to increase proteins and pursued patents, as this could greatly extend the potential for the technology in the future.

  • bbandassoc bbandassoc Jun 28, 2015 12:55 PM Flag

    Agree, except I do believe there are added effects of leaving Russell 2000 and joining Russell 1000. Clearly, these changes created substantial buying and selling in a short period of time and could have greatly influenced the 15% to 20% run up followed by the 15% to 20% run back down within 2 weeks. If another poster's info is correct, leaving the Russell 2000 could very well explain the unabated selling in recent days as the index sold its shares with no regard for anything other than they had to sell by end of last week.

  • The huge volume this evening is not buying or selling. It's simply bookkeeping for inventory that was accumulated over the past couple of weeks for the entry into the Index. The same thing happened to my own company when I was CEO and we were put in the Index.

  • Reply to

    ISIS has a lot of support at 59.

    by uptick_long Jun 26, 2015 3:42 PM
    bbandassoc bbandassoc Jun 26, 2015 6:18 PM Flag

    When they were buying the stock was going up over the past couple of weeks. This is merely bookkeeping to complete the trade at this point. Nothing is actually being bought or sold.

  • Reply to

    ISIS has a lot of support at 59.

    by uptick_long Jun 26, 2015 3:42 PM
    bbandassoc bbandassoc Jun 26, 2015 4:27 PM Flag

    Likely the other side of the trade on the shares that were accumulated for entry into the Russell 2000 Index. The shares get purchased over time once it's known a company is being added to an index and get recognized all at once.

  • Reply to

    Caught in the Biotech Headwinds

    by bbandassoc Jun 25, 2015 6:38 AM
    bbandassoc bbandassoc Jun 26, 2015 4:52 AM Flag

    Perhaps you are right and Bayer, J&J, Biogen and the others are all wrong, but I doubt it given the degree of diligence these companies all do before investing in a license deal.

  • Biotech is getting hit for reasons that don't relate to ISIS, but ISIS gets hit right along with them, for now. Biotechs have conducted a tremendous number of secondaries and several of the raises have been followed by negative trial results. This is making investors jittery for the moment on early stage biotechs. Yet, ISIS has reported extremely favorable clinical data, picked up the Bayer deal, and doesn't need cash, but it gets caught up in the swoon anyway. Won't last, but have to go with the flow in the meantime.

  • Reply to

    Needham raises ISIS target to $91.00!

    by sheckyfindlebaum Jun 24, 2015 12:07 AM
    bbandassoc bbandassoc Jun 24, 2015 9:22 AM Flag

    They also noted that they believe the data already available is sufficient to support FDA clearance for an indication in infants and children where death is the only alternative. I am from the industry and would agree, as the FDA is quick to help infants and children with no alternative treatments available. Separately, another analyst has noted that an early approval was worth $11 to $12 per share atop her $78 price target.

    Sentiment: Strong Buy

  • Reply to

    Additional Data Released

    by bbandassoc Jun 22, 2015 7:59 AM
    bbandassoc bbandassoc Jun 22, 2015 10:14 AM Flag

    Actually, this would be a perfect candidate for the FDA to move early. There are no alternative treatments. We're dealing with infants and in relatively small numbers, so a post-market study could be practical to pursue (continuing to provide data after going to market). And, there are no apparent severe side-effects with tremendous apparent benefits.

  • bbandassoc by bbandassoc Jun 22, 2015 7:59 AM Flag

    Very nice progress. Not only is the therapy halting the deterioration caused by the disease, but it is allowing the babies to make progress and without substantive safety issues. Very impressive indeed.

  • Reply to

    4% Drops

    by the_nighthawker Jun 15, 2015 3:49 PM
    bbandassoc bbandassoc Jun 15, 2015 4:18 PM Flag

    The Bayer deal and Boston Children's data IMO dramatically increase the value of the company, yet the stock is trading 10 - 20% lower than it was 3 months ago and about exactly where it was trading leading up the Bayer announcement. Hopefully, these positive milestone achievements put a floor under the stock somewhere near these levels and create the opportunity for a nice climb in the coming weeks and months. Personally, I think this is a very high potential opportunity that will take some time to unfold, but the latest announcements give me quite a lot of confidence that it will and the stock won't be anywhere near these levels if and when it does. GLTA

    Sentiment: Strong Buy

  • bbandassoc bbandassoc Jun 13, 2015 12:05 PM Flag

    This was my first exposure to the CEO and I found it truly bizarre. There was so much positive he could have said. Why didn't he just talk about what P2 was showing with regards to safety and tolerance (which is the intent of the trial), how encouraging and exciting the results are to date, and leave it at that? Why hammer the idea home that "nothing has been proven," over and over again? Even when Kramer set him up with a softball leading him to talk about the death rate and ventilation rate of patients with the ISIS treatment v. what would be expected without it, he acted like a 50% death or ventilation at 6 to 10 months without the ISIS therapy v. 0% rate with it was no big deal and again concluded by saying "nothing has been proven." It was a pathetic showing and his IR people need to prepare him better in the future, or keep him out of such venues.

  • bbandassoc bbandassoc Jun 12, 2015 8:04 PM Flag

    I respectfully disagree. While there is no doubt that a phase ii safety trial without a control group doesn't prove anything, the CEO was a complete buffoon. Of all the positive results to highlight, the only thing he could seem to focus on was that the trial "doesn't prove anything." Even Kramer tried to help him out by asking what could be expected without the treatment and he acted like it was no big deal that a 50% rate of mortality or ventilator support at 6 to 10 months v. the results wasn't that big of a deal (when it certainly is). As a new shareholder and a former medical company CEO, this was my first exposure to the CEO and I was very disappointed. It was very much amateur night from an investor relations standpoint. If he had nothing better to say, he should have declined the invitation.

  • Reply to

    A little confused

    by bbandassoc Jun 11, 2015 7:50 PM
    bbandassoc bbandassoc Jun 11, 2015 8:47 PM Flag

    Personally, I am a serious investor who was CEO of a public medical company for 17 years. I am up more than a half million on ISIS in recent weeks. Yet, I was disappointed in the CEO's performance tonight on MM. And frankly, if you knew how ridiculous you sound complaining about a company that you admittedly watched go from $7 to $70, you might find something more productive to do with your time.

  • Reply to

    A little confused

    by bbandassoc Jun 11, 2015 7:50 PM
    bbandassoc bbandassoc Jun 11, 2015 8:20 PM Flag

    Thanks, but Vical is of no interest to me. IMO, ISIS is going to be an enormous success in the coming years. I just wish he CEO were more investment community savvy because it would make life for shareholders a bit less volatile and easier.

  • bbandassoc by bbandassoc Jun 11, 2015 7:50 PM Flag

    Can someone tell me why the CEO went on MM for no apparent reason other than to hammer home the idea that nothing about the data released this morning proved anything? I am a recent shareholder sub-$57 when the market reacted negatively to what I viewed as an exceedingly positive development with Bayer, but it does concern me that the CEO (while perhaps scientifically astute) appears clueless when it comes to supporting shareholder interests.

  • Reply to

    SMN Call Seems Rather Urgent

    by riffissimo Jun 10, 2015 7:22 PM
    bbandassoc bbandassoc Jun 11, 2015 8:46 AM Flag

    The significance would seem to be the validation of the underlying technology, rather than this one application, so the implications are broader. Piggy backing on the Bayer deal, I would think the large number of shorts in this stock would be wanting to get out of their positions which could drive ISIS stock price back to, or above, its recent highs. Personally, I bought sub-$57 after the Bayer deal was announced and the stock reaction was surprisingly negative. I trade around my position, but believe this stock has legs for quite some time to come, if the data keeps coming in positive which every data point gives us more cause for confidence in the next. GLTA

  • TSLA has potential, but until Musk delivers a profitable, sustainable enterprise whose valuation is built on more than pixy dust and vapor, he looks silly making comparisons to a vibrant enterprise like Apple, or any other.

  • bbandassoc bbandassoc Feb 5, 2015 8:26 AM Flag

    I happen to like ISIS opportunity and feel the diabetes drug trial results were a non-issue since they already have other candidates that had a major impact on what this one had a minor impact. The news with Biogen this morning more than makes up for any of it, as it must be a major application to warrant such hefty milestone payments (I'm guessing Alzheimers). Besides, the majors are all looking for platform opportunities (rather than single new drugs), so one day either ISIS will be huge on its own or it will be bought for a very, very healthy premium by the likes of ABBV or others.

  • bbandassoc by bbandassoc Dec 16, 2014 8:08 PM Flag

    Just read on Yahoo that the analyst at GS has a $26 PT on LINE and doesn't expect a distribution cut with the assumption that oil will go back up later in 2015. He does have a neutral rating though. Would be nice to see.

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