As you jump up and down on that limb of yours I have chewed through half the trunk below. Happy landing.
just came across this research article on IMET. Telomerase is required for the unlimited lifespan of cancer cells through overexpressed telomerase activity and blocking telomerase could limit their lifespan.
GRN163L inhibited telomerase in all 10 pancreatic cancer cell lines;
Telomerase Inhibitor Imetelstat (GRN163L) Limits the Lifespan of Human Pancreatic Cancer Cells
AUTHOR(S)Burchett, Katrina M.; Yan, Ying; Ouellette, Michel M. Jan 2014
hope something other than short bears jump on GERN's sagging SP soon.
Interesting read rattle. Seems to me all these potential therapies surrounding telomerase inhibitions are coming closer to effective cancer remission treatments. Targeting Telomerase reverse transcriptase (TERT) a catalytic subunit or the telomerase RNA (TR) component both target cancer cells at their nuclear level during some stage of chromosomal replication are not unlike IMET that targets the RNA template of telomerase. Inhibiting expression of telomerase in cancer cells (required for their unlimited proliferation, a hallmark of cancer) is key to any effective cancer treatment. Accordingly, the inhibition of telomerase in cancer cells leads to telomere attrition and limits the lifespan of these cells. I can see some sort of HART- like treatment approach in the future with these various inhibitors.
hTERT gene has been used successfully to promote the growth of hair follicles but so far limited success wrt cancer therapy. Could you name any specifics?
I've read about Androgen therapy & it's TERT related therapeutic possibility.
IMETS toxicity was rectified by dosing adjustments and limited to elevated LFT which were shown to be reversed as in the MC 1ST and subsequently that IND`s hold lifted.
what numbers have you got for tutes? I'm finding ranges anywhere from 38%, 48% depending on site used.
Faruqi & Faruqi ambulance chasers still adv. trolling the internet hi-way for accident body parts. The company has not published a press release since announcing its second quarter financial results on Aug. 11th, 2014 making this open season for the current short bear raid. We still have no clear indication on whether the MF Phase II will be allowed to continue in the US.
JAKAFI with only limited symptomatic relief seems to be gaining momentum and further indication approvals by the FDA coming in Dec. despite it's many serious safety concerns.
GERN's science and it's latest MF trials, although producing first in class complete clinical remission results appears to be bogged down in a myriad of problems some perhaps self generated but many brought about more obviously by a powerful, money backed INCY lobby group determined to at least delay GERN's advancement, at worst force the company into BK or forced sale only to pick up the pieces to market it for themselves. GERN's current SP is trading at only $.40 above it's cash reserve, which thankfully Scarlet executed earlier this year. Could u imagine the SP without the current cash reserve? This full clinical hold, questionable in nature was with little doubt inspired by the powerful INCY lobby and their control on the various FDA review & control panels.
Was that Tina Steele of Edith's cakes and catering? They won first prize in the Downtown Beaver Dam Holiday Decorating Contest last year.
Edith's cakes and Catering was chosen by popular vote as the best of them all. It featured a runaway handcrafted train, advertising the many baked in specialties offered by the restaurant.
Final Results for the Window decorating Contest
1st Place: Ediths Cakes and Catering - 103 Front St.
2nd Place: Twisted Sisters, 112 S Spring St.
3rd Place: Change of Heart Ministry 114 Front St.
he signed off on the S&E publication
This appears he seems to have changed sentiments lately on JAK
better in bed with the devil you know(IINCY) rather than the one you don't(FDA)
Today's number is 2.6 mil meaning 1mil shorts should have covered from yesterday, and yet no short squeeze. In fact the price fell another 3%
With only 600K vol that means 400K covered from their wazoo. Obviously these figures don't reflect the games being played here.
that's why I seldom recommend other stocks or even post sentiments. The best laid plans of mice and men often go awry.
well they only have 1.6mil left. After that they'll all be naked.
Is this your new handle E2 prior to ASH?
if GERN is a supporter why aren't they presenting in any of the program's summary discussions? I don't see any light at the end of this tunnel ?
interactive brokerage publishes daily updates on shorts availability. If the number goes up that means they're covering. If down they bought more positions. It covers several brokerages totals.
there is also a consideration that geron could use the MC's MF First trial data to apply to the liver enzyme data reversibility requests by the FDA. Different trials but similar dosing & LFT data albeit fewer Patients surviving late stage MF. With Geron assuming the MC MF First trial I can't see why the FDA would not approve their request for an expanded phase II trial to start
'Second comment says why not $20'. I say why not beyond $50 like INCY is now with a drug that can only deliver symptomatic relief not complete remissions like GERN's can.
What does he think of the Tesla model S, few mechanical parts, unlike an obsolete standard gas combustion engine and at $35K for a previously owned model with extended warranty, very affordable.
I'm so excited in anticipation,
I can't hold it any longer.
I'm praying on you tonight
Hunt you down meet you alive
Just like animals
Maybe you think that you can hide
I can smell your scent for miles
Just like animals
Don't tell no lie, lie lie lie
You can't deny, ny ny ny
That be Ash inside, side side side
Yeah yeah yeah
critter animal song