Us wild critters down at the pond are somewhat independent of the farmer, yet somehow still affected by what goes on at the farm. Just make sure the pigs don't take control.
also take into account the severity of the condition of patients enrolled in the study. All were in advanced stages of MF and subject to more sensitivities of possible side effects either by their disease advancement or by the drug or in combination. Myelosuppression was reduced or eliminated with dosing adjustments. Unlike with Jak2, immunosuppression was not brought up as a side effect.
Any technicals can apply if you want them to. OHRP is a news story based stock. It's all about perception. When the SP was heading to $20 retailers were quickly jumping on board pushing it up to Livermore's lofty targets. The stock had resilience as was seen with the quick recovery from A Fartstain#$%$ piece on OHRP being a pump & dump. The unexpected dilution(after they don't need the money expectations) at a much lower than market price killed the up trend. Now we can't even hold the We all wait either on the sidelines or in the stock awaiting results in June to substantiate the science or not.
" Imetelstat currently is known to be effective only for high risk patients and not so for low-risk patients" ....how do we know this currently? Imetelstat has only been used on high risk advanced stage patents to date. There have been no low risk studies conducted yet.
I America it's the one percenters. In Russia it's Putin's oligarchies. In Venezuela it's Cuban backed pro communist militia. In GERN it's the JAK lobby. In Hodge Podge Lodge it's Baxter the badger. Everywhere it's something. If these students were working as hard as the "working poor" to feed their families they wouldn't have time to protest. That's the way the 'man' has set the game.
...would be nice but have my doubts. Imetelstat would have to become the aspirin of cancer treatment. Wait a minute...that sounds familiar.
....we would have told you what the mood of the board was had you told us before GERN was hit by the MACK truck speeding by. For your own safety do not disclose your Hollywood connections .....we have a McCarthy witch hunt in progress.
....remember what Irish said 🌻 🌻 -🌻=🌻 You're now down to one flower now Maine.
If you keep this up it will soon be 💐 R.I.P.💐
Jakafi oral side effects Drug Overview, Webb MD
The following common side effects are associated with Jakafi oral:
Abnormal Liver Function Tests; Severe
Decreased Blood Platelets; Severe
Decreased Neutrophils a Type of White Blood Cell; Severe
Why is IMETELSTAT with clearly less effects, certainly none severe set to much higher standards of LFT data procurement by the FDA in the clinical trial requirement phases on ET & MF?
The FDA is clearly complicit in this matter concerning the hold.
Scarlet did say they've had no discussions with the FDA on required data since the hold. He's scrounging around his office looking fur LFT data in animal studies for Pete's sake.
Sounds like he's been playing a lot of golf in the seven weeks since the hold.
Hay I didn't forget. Those were listed as moderate side effects of Jakafi, not worthy of FDA concerns wrt clinical trials. We won't get into sudden death syndrome and brain lesions caused by Jakafi on this public forum. Could end up becoming targeted road kill critters.
It ticks me off that FDA has apparently no bar set on Jakafi's severe side effects, a drug that has very limited effects on MF cancer patients but yet places an ambiguous low liver function test hold on Imet for far less severe, if any, classified side effects.
Irish needs to start a petition bringing forth the obvious double standard set by the FDA wrt to these two treatments. New MF patients are dying every day this hold is on.
....not forgetting to mention the impending law suit but I think it contributed to the impression Chippy was trying to give in that he had no clue about the data wrt to the MAYO trials... He'll know at the next ASH presentation unless the info is shared by Tefferi.
Thanx fur the shamrock but I need that pot o' gold Irish. The landlord is coming and I can't pay the lodge rent. He's mean old bear, like the one that keeps raiding the gerny.
Kool it's not a sense that they'll never be able to get info required by the FDA but more a sense that although already submitted via previous phase trials they are unaware of what the FDA really requires for a lift on the GERN portion of the trials without determining the exact cause of abnormal LFT. Reversibility may be an impossible task given the LFT can be caused by the disease itself. Is the FDA asking for the impossible? And if so why and why now? Two different studies, GERN and MAYO, two seemingly completely different protocols. Hopefully MAYO scores the win. It's all we got.
If Geron can show the LFTs are reversible, be it through the MAYO data or their own(which doesn't sound as promising) then the new trials would likely include all stages of Myelofibrosis.
Chippy would probably lose it in the piles of paper he's stuffing into boxes for the FDA. After 7 weeks he may need another office for added space required. It sounded to me like he had pretty well given up on actively attempting to challenge the FDA's ET hold, almost like he realizes it's a useless endeavour given the FDA's complicit action on the trial at this juncture. INCYTE has deeper pockets than anyone expected