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SIGA Technologies, Inc. Message Board

beavertail_splash 2764 posts  |  Last Activity: 5 hours ago Member since: Apr 13, 2007
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  • beavertail_splash by beavertail_splash 5 hours ago Flag

    Even to Pigsdonteatpork.
    No sign of shorts, naked or otherwise.

  • Reply to

    BULLISH HARAMI CROSS

    by beavertail_splash Dec 16, 2014 8:04 PM
    beavertail_splash beavertail_splash Dec 16, 2014 8:07 PM Flag

    Stocks TA
    "Recent CandleStick Analysis
    Bullish
    Date Candle
    Dec-16-2014 Homing Pigeon
    Dec-15-2014 Bearish Engulfing "

  • beavertail_splash by beavertail_splash Dec 16, 2014 8:04 PM Flag

    much better than last week's golden shower.
    from American Bulls
    "Compare the pattern’s strength and reliability with the market to help you in your buying decisions.
    BULLISH HARAMI CROSS
    Definition
    This is a major bullish reversal pattern, which is even more significant than a regular Bullish Harami. The outline again looks like a pregnant woman, as with the Bullish Harami Pattern. However, now the baby is a Doji. Basically, the pattern is characterized by a black body followed by a Doji that is completely inside the range of the prior black body.
    Recognition Criteria
    1. The market is characterized by a prevailing downtrend.
    2. A black body is observed on the first day.
    3. The Doji that is formed on the second day is completely engulfed by the body of the first day.
    Pattern Requirements and Flexibility
    The Bullish Harami Cross consists of two candlesticks, in which the body of the first black candlestick engulfs the body of the following Doji. The body of the first candlestick may be short.
    Trader’s Behavior
    A bearish mood prevails in the market, and a downtrend is in progress. The first day’s candlestick is a black body, which further supports bearishness. However the next day, prices open higher than the close, or at the close of the preceding day. The short traders are alarmed which leads to the covering of many short positions, causing the price to rise further. Moreover, the day closes at the opening price, showing lack of decision among traders. The increasing level of indecision and uncertainty amplifies the likelihood of a trend change and cause a reversal."

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 7:56 PM Flag

    like I said earlier Promedior was working with combo therapies using ruxolitinib combos and by itself...see phase 2 results below. It very well could have been the INCY lobby behind their trial advancements and what looks to be less impressive using a smaller sample base but never the less still very promising test results when compared to GERON's trials.
    Would like it if Irish could weigh in on their drug. She must have heard of it via the MPN forum.

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 5:31 PM Flag

    She sounds German wonder if Joane knows her?

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 5:29 PM Flag

    they even have their own "public" poster girl.
    Voncille Fryou, Patient F, tells her story.
    "It’s rare that we get to see and hear one of our own, a patient step out from the PowerPoint the charts and graphs of a clinical trial report and tell us her story. Here’s Voncille. If you follow the rows of the chart, above, you’ll find Patient F, second from the bottom. Reading across you can see she’s the PRM-151 Poster Girl not for any dramatic change in counts — they mostly held steady except her MPN-SAF score, her total symptom score, is on an upward trend line. She seems to have had a bone marrow response, reversal of fibrosis. As Dr. Verstovsek cautions, all bone marrow data is provisional until the blinded review is completed. What isn’t provisional is Voncille’s spirit and willingness to share her experience. "

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 5:27 PM Flag

    yeah that misnomer had to be clarified earlier. It was Mayo 1ST in that it was First in class drug study using Imet. but actually was phase 2 study.
    "In January 2011, GERON initiated a Phase 2 clinical trial of imetelstat in patients with ET. The Phase 2 ET trial was a multi-center, single arm, and open-label trial that we designed to provide proof-of-concept for the potential use of imetelstat as a treatment for hematologic myeloid malignancies, including MF, MDS and AML. The trial leveraged clinical observations from Phase 1 trials suggesting that imetelstat reduces platelet counts, as well as non-clinical observations that imetelstat distributes well to bone marrow in rodent models and selectively inhibits the proliferation of malignant progenitors ex vivo from patients with ET. Hematologic responses were measured by reductions in platelet counts, and molecular responses were measured by reductions in the JAK2 V617F mutant allele burden in circulating granulocytes as assessed by reduction in the proportion of the abnormal Janus kinase 2, or JAK2, gene compared to the normal, or wild type JAK2 gene. We believe a decrease in the proportion of the JAK2 V617F mutant relative to the wild type JAK2 is consistent with selective inhibition of the malignant progenitor cells responsible for the disease."

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 5:06 PM Flag

    your right Taz, I missed it earlier; only seeing orphan designation.
    Nov.3 2014 The FDA granted fast track designation to PRM-151 as a potential treatment for patients with myelofibrosis, the drug’s manufacturer announced.
    Highlights from ASH 2014
    Highlights from ASCO 2014
    Leukemia Resource Center
    Highlights from HemOnc Today Melanoma and Cutaneous Malignancies
    The designation encompasses three indications: primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 2:05 PM Flag

    orphan drug is not fast track designation.

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 2:02 PM Flag

    Didn't Chippy closed down the Menlo site pretty well? He uses it for a Porsche parking lot. He was waiting for a deal like Janssen to move this fwd. not having in house facilities of his own anymore to pursue clinical testing.
    U were right he did not seem pumped on pursuing fast tracked earlier last year. Don't know if things have changed with J&J on board but this space s getting some other action.

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 1:54 PM Flag

    obviously they're working with INCTE on this.(combo) There may lie your answer.

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 1:52 PM Flag

    Promedior reports that the preliminary Phase 2 data for PRM-151 were presented for 27 patients with myelofibrosis, 18 of whom completed 24 weeks of therapy. PRM-151 demonstrated a 50% reduction in symptoms according to the MPN-SAF2 Total Symptom Score in 7 patients, 5 of which have persisted for 12 weeks and are therefore confirmed IWG-MRT3 Clinical Improvement symptom responses; 5 reductions in bone marrow fibrosis by 1 grade, with 2 of 3 patients confirmed 12 weeks later and 2 patients pending confirmatory biopsy; a 20% reduction in spleen volume reduction in 5 patients with one 50% reduction lasting 8 weeks; and improvements in hemoglobin and platelets. Each treatment group demonstrated improvements that met the pre-specified efficacy criteria for further exploration of PRM-151 in the second stage of this adaptive Phase 2 trial. Fifteen out of 18 patients who have completed the 24 week study are continuing treatment in a study extension.
    In this study, PRM-151 was safe and well tolerated on weekly and monthly dosing schedules, both alone and in combination with ruxolitinib, with no evidence of myelosuppression. Most adverse events observed in the study were Grade 1 or 2 and considered unrelated to PRM-151. Overall, there were 14 severe adverse events (SAEs) in 5 study patients, including 3 deaths, 2 from pneumonia and 1 from progressive multi-organ failure. Other SAEs were abdominal pain, bone marrow biopsy site hematoma, sialadenitis, gastroenteritis and respiratory syncytial virus. The Company expects to report the complete first stage results of this ongoing Phase 2 study by the end of 2014.
    This Phase 2 trial is a multi-center, two stage, adaptive design study to determine the efficacy and safety of PRM-151 as a single agent or added to a stable dose of ruxolitinib in patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (post-PV MF), or Post-Essential Thrombocythemia MF (post-ET MF). 27 patients were enrolled in the first stage of the study;"

  • Reply to

    can someone explain to me?

    by ligas3 Dec 16, 2014 12:45 PM
    beavertail_splash beavertail_splash Dec 16, 2014 1:50 PM Flag

    PRM-151 still has to run phase 2 stage studies. About as advanced as GERON in the development phase. PRM-151 has Orphan Designation in the US and EU for treatment of IPF and in the US for the treatment of myelofibrosis — a type of myeloproliferative neoplasm — a serious, life-limiting cancer that is characterized by fibrosis of the bone marrow.
    " Phase 1b clinical trial was a randomized, double-blind, placebo-controlled study in 21 patients with IPF. Promedior measured the impact on bone marrow health, according to a scoring system that takes various side effects like spleen size and anemia into account (officially called the Myoproliferative Neoplasm Symptom Assessment Form). Seven out of the 18 patients had a 50 percent reduction in that score, and 5 of them saw their fibrosis reduced by at least one grade. A “number” of the patients on PRM-151 saw their levels of platelets and hemoglobin improve, though Bruhn wouldn’t specify how many. She says most of the side effects patients experienced were mild" The drug is based on a natural human protein so toxicity isn't an issue.

  • Reply to

    can shorts continue to drive price down

    by caseykasem67 Dec 16, 2014 7:50 AM
    beavertail_splash beavertail_splash Dec 16, 2014 8:57 AM Flag

    hope not...I hated the last weak week of trading we went through. I was sure that our psychopathic pig farmer MM was taking us down to fill that $2.40-$2.70 gap.

  • Reply to

    CURRENT SHARE PRICE OF $3.03 IS DUE TO CORRUPTION!

    by jackdaw605 Dec 15, 2014 10:16 AM
    beavertail_splash beavertail_splash Dec 15, 2014 5:47 PM Flag

    3.2million shorts available. 100,000 more today than this morning.

  • Reply to

    Check FINVIZ's chart

    by beavertail_splash Dec 15, 2014 11:15 AM
    beavertail_splash beavertail_splash Dec 15, 2014 11:41 AM Flag

    because it's not $4.03 it's $2.96. In a perfect world we'd all be hedge fund owners discussing where on St Bart's we'd be spending Christmas.

  • Reply to

    Check FINVIZ's chart

    by beavertail_splash Dec 15, 2014 11:15 AM
    beavertail_splash beavertail_splash Dec 15, 2014 11:35 AM Flag

    Could see a move back to SMA of $3.45 today. Anyone see a bullish harami candle formation?

  • Reply to

    short sale restrictions

    by rusty_98070 Dec 15, 2014 11:14 AM
    beavertail_splash beavertail_splash Dec 15, 2014 11:28 AM Flag

    I believe we hit the strong support line or close to. In other words the bottoms in and tomorrow we should start heading back to $4.03.
    I say that with bated beaver breath. Been fooled bfr in GERN

  • Reply to

    Check FINVIZ's chart

    by beavertail_splash Dec 15, 2014 11:15 AM
    beavertail_splash beavertail_splash Dec 15, 2014 11:23 AM Flag

    based on this chart and GERN's high RT value (indicates how fast it moves) this could be the bottom and swing traders will again jump back in pushing the price back up. Where's End2war?

  • Reply to

    Check FINVIZ's chart

    by beavertail_splash Dec 15, 2014 11:15 AM
    beavertail_splash beavertail_splash Dec 15, 2014 11:18 AM Flag

    Gern's elevator may have not even hit the bottom floor. Going Up?

SIGA
1.42-0.04(-2.74%)Dec 17 3:59 PMEST

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