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Dynavax Technologies Corporation Message Board

bewarescardycat 3 posts  |  Last Activity: Nov 30, 2014 9:03 PM Member since: Oct 25, 2008
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  • Reply to

    Lorcaserin best per just released study

    by sauve9 Nov 30, 2014 5:23 PM
    bewarescardycat bewarescardycat Nov 30, 2014 9:03 PM Flag

    nice find

  • Prognostic Value of Remnant-Like Lipoprotein

    Particle Levels in Patients With Coronary

    Artery Disease and Type II Diabetes Mellitus

    Hironobu Fukushima, MD,* Seigo Sugiyama, MD, PHD,* Osamu Honda, MD,* Shunichi Koide, MD,*

    Shinichi Nakamura, MD,* Tomohiro Sakamoto, MD, PHD,* Michihiro Yoshimura, MD, PHD,*

    Hisao Ogawa, MD, PHD,* Daisuke Fujioka, MD,† Kiyotaka Kugiyama, MD, PHD†

    Yamanashi and Kumamoto, Japan

    OBJECTIVES This study prospectively examined whether the levels of high remnant-like lipoprotein

    particles (RLP) cholesterol have a significant risk and influence prognosis in patients with

    coronary artery disease (CAD) and type II diabetes mellitus (DM).

    BACKGROUND Several studies have shown that triglyceride-rich lipoproteins contribute to atherosclerotic

    complications in type II DM. However, it remains to be established which triglyceride-rich

    lipoproteins contribute to this risk.

    METHODS Levels of RLP cholesterol in fasting serum were measured by an immunoseparation method

    in 240 type II DM patients with (n _ 120) or without (n _ 120) CAD. The patients with

    CAD were followed up for a period of _24 months until the occurrence of one of the

    following clinical coronary events: re-admission or coronary revascularization due to recurrent

    or refractory angina pectoris, nonfatal myocardial infarction, or cardiac death.

    RESULTS Patients with CAD had higher RLP levels than patients without CAD. Multivariate logistic

    regression analysis showed that high RLP cholesterol levels (_4.7 mg cholesterol/dl,

    representing the 75th percentile of the distribution of RLP cholesterol levels in control

    subjects) were a significant risk factor for the presence of CAD, independent of traditional

    risk factors. Kaplan-Meier analysis demonstrated that higher RLP cholesterol levels in

    patients with CAD resulted in a significantly higher probability for the development of

    coronary events. Multivariate Cox hazards analysis showed that high RLP cholesterol levels

    in patients with CAD were a significant predictor of future coronary events, independent of

    other risk factors.

    CONCLUSIONS Increased levels of RLP cholesterol are a significant and independent risk factor of CAD and

    predict future coronary events in patients with CAD and type II DM. (J Am Coll Cardiol

    2004;43:2219 –24) © 2004 by the American College of Cardiology Foundation

  • looking for home runs makes the current PPS absurd but that will change...

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