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Star Scientific, Inc. (CIGX) Message Board

bhp1rtp 62 posts  |  Last Activity: Apr 2, 2014 5:25 PM Member since: Dec 3, 2011
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  • From the Anatabine Ameliorates Experimental Autoimmune Thyroiditis study
    Anatabine restored expression of IL-18

    From Trinity College Dublin
    The scientists found that a component of the immune system, 'IL-18', acts as a guardian of eyesight by suppressing the production of damaging blood vessels behind the retina at the back of the eye.
    Age-Related Macular Degeneration (AMD) is one of the most common forms of blindness in the aging population. The disease involves a loss of central vision, such that people suffering at advanced stages are unable to read, watch TV, drive, or use computers.
    There are two forms of AMD: 'dry' and 'wet'. Dry AMD accounts for the majority of cases, but wet AMD causes over 90% of blindness associated with the disease. In wet AMD, blood vessels underneath the retina begin to grow abnormally, which causes almost immediate central blindness.
    Treatment options for wet AMD are currently limited to the end stages of the disease. Regular injections of antibodies must be made directly into the eye to mop up a problematic molecule termed 'VEGF'. However, the Trinity scientists found that IL-18 directly inhibits VEGF production,.

    Sentiment: Strong Buy

  • A review at Supplement Geek

    Judith Auerbach says

    March 28, 2014 at 7:11 pm
    I’ve been taking it for my Hashimoto’s and it has been working very well. My antibodies are down to zero.

    Sentiment: Strong Buy

  • Dr. Mullan likes to show the video about the rats swimming in water and how Anatabine affected their performance.

    In 2003 the following study was published in Molecular Therapy
    Acetylcholine-Secreting Cells Improve Age-Induced Memory Deficits

    The study examined whether aged rats with naturally occurring cognitive deficits in spatial learning and memory would benefit from local chronic supplementation of acetylcholine. The results appear to be the same as the Roskamp results using Anatabine.

    The fact that the results appear to be the same using Acetylcholine-Secreting Cells and using Anatabine suggests that Dr. Mullan may be correct when he suggest Anatabine mimics the affect of acetylcholine when it bonds to a7-nAchR

    Sentiment: Strong Buy

  • Reply to

    Use of Anatabine to Treat Epilepsy and Autism

    by bhp1rtp Mar 27, 2014 12:42 PM
    bhp1rtp bhp1rtp Mar 27, 2014 6:53 PM Flag

    Researchers at the Johns Hopkins Bloomberg School of Public Health contributed to a new Centers for Disease Control and Prevention (CDC) report that estimates the prevalence of autism spectrum disorder (ASD) at 1 in 68 U.S. children overall, an increase of 29 percent since the last such report in 2012. Broken down by gender, the overall rate is 1 in 42 boys and 1 in 189 girls.

    ASD encompasses a wide spectrum of conditions that affect communication, social and behavioral skills. The causes are not completely understood, although studies show that both environment and genetics play an important and complex role. There is no known cure

    Sentiment: Strong Buy

  • Reply to

    Periodontal bacteria thrive on inflammation.

    by bhp1rtp Mar 27, 2014 1:40 PM
    bhp1rtp bhp1rtp Mar 27, 2014 2:35 PM Flag

    Mayo Clinic Health Letter

    Some scientists believe that bacteria from gum disease can enter the bloodstream and make its way to the heart.

    Sentiment: Strong Buy

  • Penn Dental Medicine-NIH Team Reverses Bone Loss in Immune Disorder

    Consuming the breakdown products of tissues is how Periodontal bacteria get their food. So if you inhibit inflammation you starve Periodontal bacteria ."

    Sentiment: Strong Buy

  • Use of Anatabine to Treat Epilepsy and Autism

    Beverage patent

    [0303] A 10-year old male patient, who was diagnosed with autism and a seizure disorder, had brain surgery and began rehabilitation the following month. About 4 months later, in addition to continuing rehabilitation, he began a course of treatment with 1.0 mg of anatabine three times per day. Over the course of 31/2 weeks the frequency of the patient's seizures decreased from one per day to approximately one per week. The patient also experienced cognitive benefits beginning approximately one week after the start of the anatabine treatment, with noticeable improvements daily. These benefits included improved communication and language skills and the ability to focus.

    Sentiment: Strong Buy

  • bhp1rtp bhp1rtp Mar 27, 2014 11:54 AM Flag

    WARM-BLOODED ANIMALS

    Beverage Patent

    "Individual" as used herein includes warm-blooded animals, typically mammals, including humans and other primates. In some embodiments, the individual is an animal such as a companion animal, a service animal, a farm animal, or a zoo animal. Such animals include, but are not limited to, canines (including dogs, wolves), felines (including domestic cats, tigers, lions), ferrets, rabbits, rodents (e.g., rats, mice), guinea pigs, hamsters, gerbils, horses, cows, pigs, sheep, goats, giraffes, and elephants. In some embodiments, the individual is a non-human mammal.

    Sentiment: Strong Buy

  • bhp1rtp bhp1rtp Mar 27, 2014 11:46 AM Flag

    HAIR LOSS

    Beverage Patent

    [0131] In some embodiments, a therapeutically effective dose of an isolated form of a compound of Formula I or IA (e.g., anatabine or S-(-)-anatabine) or a salt thereof can be administered to an individual for treating alopecia greata or other disorders associated with hair loss.

    Sentiment: Strong Buy

  • bhp1rtp bhp1rtp Mar 27, 2014 11:44 AM Flag

    ERECTILE DYSFUNCTION

    Beverage Patent

    [0130] An isolated form of a compound of Formula I or IA (e.g., anatabine or S-(-)-anatabine) or a salt thereof can also be used to improve erectile dysfunction, either administered alone of in conjunction with other therapies such as tadalafil (e.g. CIALIS®), vardenafil (e.g., LEVITRA®, STAXYN®), and sildenafil (e.g., VIAGRA®).

    Sentiment: Strong Buy

  • Does Anatabloc help your Daiabetes?

    The FDA wants to know what helps relive diabetes.

    If you or someone you know use Anatabloc and you or they think it helps your diabetes let the FDA know.

    The below article appears on FDA's Consumer Updates page, which features the latest on all FDA-regulated products

    "Consumers, especially members of minority communities, should tell us about their good and their bad experiences with their medications and treatments. If they have any reactions to a certain diabetes medication or if they find that one treatment works better for them than another, we want to know, because that information can be useful to others too,"

    The Office of Minority Health (OMH) at the Food and Drug Administration (FDA) is building relationships with the American Diabetes Association (ADA) and other groups to help Americans prevent and treat diabetes, and to address the disparity in how severely it affects minority groups in particular

    Diabetes is a high priority for OMH because racial and ethnic minorities have a higher burden of diabetes, worse diabetes control and are more likely to experience complications (for example, among Hispanics, the death rate from diabetes is 50% higher than for non-Hispanic whites).

    Diabetes affects nearly 26 million Americans (8.3% of the population). In addition, about 79 million adults (35%) are at risk of developing diabetes.

    Go to fdaDOTgov/safety/medwatch/default

    Sentiment: Strong Buy

  • bhp1rtp bhp1rtp Mar 25, 2014 5:37 PM Flag

    IMO the decision on which disease to purse will take into consideration

    1. How long does it take to see results from treatment
    2. Will the treatment qualify for Breakthrough Therapy Designation

    A breakthrough therapy is a drug: intended alone or in combination with one or more other drugs to treat a serious or life threatening disease or condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical development.
    If a drug is designated as breakthrough therapy, FDA will expedite the development and review of such drug. All requests for breakthrough therapy designation will be reviewed within 60 days of receipt, and FDA will either grant or deny the request.

    Sentiment: Strong Buy

  • Depletion of gut microorganisms by Antibiotics

    My observation

    Both Antibiotics and Anatabine influence immune cell function. The difference between Anatabine and Antibiotics is Anatabine to my knowledge does not deplete gut microorganisms. The fact that Antibiotics deplete gut microorganisms might be part of the reason there are so many side effects from Antibiotics and we are not seeing those side effects with Anatabine.

    The Three recent studies that led to the above observation

    Google

    Research Study Takes Deeper Look at the Role of Gut Microbes in the Immune System

    New research suggests that taking antibiotics depletes gut microorganisms and the human body needs gut microorganisms to support the production of immune cells that form the first line of defense against infection.

    Google

    Gut bacteria essential for immune cell development

    A new study finds that gut bacteria play an important role in the development of white blood cells that help the body's immune system fight infection.

    The human body is home to thousands of species of microbes - collectively known as the microbiome - that we are increasingly coming to realize are essential to health. The highest concentration and diversity of these species is found in the gastrointestinal tract, and the colon in particular.

    Google

    Microbes help to battle infection: Gut microbes help develop immune cells, study finds

    Beneficial gut bacteria are necessary for the development of innate immune cells -- specialized types of white blood cells that serve as the body's first line of defense against invading pathogens -- new research has found. The research suggests that a healthy population of gut microbes can actually provide a preventative alternative to antibiotics

    Sentiment: Strong Buy

  • Mr Jenkins investment friends left the cold north and came down south to get some sun and information. I suspect Mr Jenkins will be spending a lot of time with his investment friends. He might even invite them to dinner with his newest friends.

    Sentiment: Buy

  • Did I hear 50,000,000 tablets sold and no major adverse effects.
    It will be hard for the FDA to say this product is not safe.
    Safety is not the issue
    The only issues is how the FDA reads the law and weather they want the public to believe a supplement can cure autoimmune conditions

  • Brochure - Roskamp Institute

    rfdnDOTorg/marketing/RI_BrochureDOThtml

    Sentiment: Strong Buy

  • Will the FDA allows the dietary supplements and require a new brand name for the pharmaceutical version?

    Is this part of the negotiations taking place at this time between Star and the FDA?

    From the FDA web site

    Can a Dietary Supplement Treat a Concussion? No

    From the 10-k

    Any brand names we intend to use for our product candidates will require approval from the FDA regardless of whether we have secured a formal trademark registration from the U.S. Patent and Trademark Office. The FDA typically conducts a review of proposed product brand names, including an evaluation of potential for confusion with other product names. The FDA may also object to a product brand name if it believes the name inappropriately implies medical claims. If the FDA objects to any of our proposed product brand names, we may be required to adopt an alternative brand name for our product candidates. If we adopt an alternative brand name, we would lose the benefit of our existing trademark applications for such product candidate and may be required to expend significant additional resources in an effort to identify a suitable product brand name that would qualify under applicable trademark laws, not infringe the existing rights of third parties and be acceptable to the FDA

    Sentiment: Strong Buy

  • Anatabine ameliorates the immune system’s targeting of the thyroid

    Now the education starts. The results suggest they have a product that ameliorates an autoimmune disease. Starting with the investor conference the push will be on to help the investment community understand what this could mean.

    On January 7, 2013 Rock Creek reported initial results for its Thyroid health study. Those results suggest that dietary supplementation with anatabine ameliorates the immune system’s targeting of the thyroid gland in cases of autoimmune thyroiditis. On October 31, 2013 the results of the Thyroid Health Study were published on-line in The Journal of Clinical Endocrinology & Metabolism in a peer-reviewed brief report entitled “Anatabine supplementation decreases thyroglobulin antibodies in patients with chronic lymphocytic autoimmune (Hashimoto’s) thyroiditis”.

    Sentiment: Strong Buy

  • Alzheimer’s study suspended pending filing of an IND

    The Alzheimer’s study that is being sponsored by Rock Creek and conducted at and paid for by the Roskamp Institute began enrolling subjects at the end of August 2012. As of March 1, 2014, 83 subjects had been screened, 62 subjects had been enrolled in the study and 53 subjects had completed the study. This study has now been suspended pending filing of an IND but an interim analysis is anticipated, the results of which may influence the decision to proceed with the study under an IND

    They have the results of the 53 subjects that completed the study. This is exactly what they need to get Big Pharma excited.

    Sentiment: Strong Buy

  • bhp1rtp bhp1rtp Mar 15, 2014 2:48 PM Flag

    From the Journal THYROID
    Obesity and Thyroid Cancer: A Clinical Update
    Published in Volume: 24 Issue 2: February 11, 2014
    Online Ahead of Print: September 25, 2013
    Online Ahead of Editing: July 23, 2013

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