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Dynavax Technologies Corporation Message Board

bigredkachina 17 posts  |  Last Activity: 20 hours ago Member since: Aug 12, 2005
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  • Mademoiselle, you have the choice. You can pee in a cup or partake in zee colposcopically-directed punch biopsy. Which do you prefer?

    Human papillomavirus (HPV) testing in urine offers a convenient approach for cervical cancer screening but has previously suffered from limited clinical sensitivity.
    We evaluated clinical performance of the prototype Trovagene HPV test, a novel polymerase chain reaction assay that targets the E1 region of the HPV genome and detects and amplifies short fragments of cell-free HPV DNA in urine.
    We conducted a pilot study among 72 women referred to colposcopy following abnormal screening. Participants provided a urine sample prior to clinician-collected cervical sampling and colposcopically-directed punch biopsy. Trovagene HPV test results on urine samples were compared with cervical and urine testing by Linear Array HPV Genotyping Test (LA-HPV) for detection of histologically-confirmed cervical precancerous lesions.
    There was high concordance between urine samples tested by the Trovagene HPV test and corresponding cervical (87.5%) and urine (81.9%) samples tested by LA-HPV. The Trovagene HPV test had high sensitivity (92.3% for detecting CIN2/3, and 100% for CIN3), comparable to LA-HPV testing on cervical samples (96.0% and 100%, respectively), and higher than LA-HPV testing on urine samples (80.8% and 90.0%, respectively). In this referral population, the specificity of the Trovagene urine HPV test was non-significantly lower (29% for CIN2/3 and 25% for CIN3) than corresponding estimates of LA-HPV testing on cervical (36% and 28%, respectively) and urine (42% and 38%, respectively) samples.
    This pilot study suggests that the Trovagene HPV test has high sensitivity for urine-based detection of cervical precancer and merits evaluation in larger studies.
    Affiliation
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

  • bigredkachina by bigredkachina Jul 23, 2014 8:40 AM Flag

    Experian is a 1 trillion dollar market cap corp. Surely there is something in it for BKYI. Should see some movement in pps as news gets out.

  • bigredkachina by bigredkachina Jul 22, 2014 3:23 PM Flag

    It isn't short selling because short interest is down to 4.13% from 4.19%. Every move up countered with dump. Limitless shares to meet lower and lower bid.

  • Applications: Mobile Devices, Government, Defense, Healthcare, Commercial Security and Banking & Finance.

    Expected market: 15 billion.

  • bigredkachina by bigredkachina Jun 16, 2014 3:42 PM Flag

    Just bought another wad of EGHT this morning. It is oversold here and will be back at 10 before you know it.

  • Reply to

    Sold Shares

    by bigswan1979 Jun 15, 2014 9:42 AM
    bigredkachina bigredkachina Jun 16, 2014 3:31 PM Flag

    I must say you have exquisite timing Mr. Swan. Name of the game is buy low sell high, but you know that don't you? Don't you?

  • Reply to

    Where are all the KAD?

    by mannchris686 Jun 11, 2014 10:09 AM
    bigredkachina bigredkachina Jun 11, 2014 1:27 PM Flag

    Here's a suggestion for you putz. Instead of contacting Scottrade for certificates why don't you use some of those counterfeit shares you guys are bandying about here to wipe your #$%$ with? Better get a big handful tho, as you are so full of #$%$ you will need a couple thousand just to take a dump.

  • Reply to

    Where are all the KAD?

    by mannchris686 Jun 11, 2014 10:09 AM
    bigredkachina bigredkachina Jun 11, 2014 10:29 AM Flag

    So, the price dips and the Village Idiot is back squirting all over herself. What else is new.

  • Reply to

    Price Action

    by mannchris686 Jun 3, 2014 10:21 AM
    bigredkachina bigredkachina Jun 3, 2014 4:20 PM Flag

    I see Henny Penny village idiot is back at it again. One day the sky WILL fall but it won't be here, putz.

  • That has a nice ring to it. Can't decide whether I like the multi-disciplinary part or clinical consensus part better. In any event it proves that TROV technology is the go-to solution for monitoring BRAF V600E mutations in Erdheim-Chester disease. Yeah, I know it is a niche area compared to the overall cancer arena, but TROV was 100% for all patients and it is an area where biopsies are impractical much of the time. Study done at MD Anderson, guidelines published at Sloan-Kettering.

    So, the beat-down continues. I guess TROV is easy prey for the sharks right now, seeing as they haven't had any significant revenues to date. Currently one has to be satisfied that the technology is being validated and at some point in time revenues will follow.

  • Only peg left is earnings shortfall and that will diminish as earnings from new contracts start hitting the books this fall and beyond. I see 2+ here by Labor Day.

  • bigredkachina by bigredkachina May 19, 2014 2:17 PM Flag

    Picked up another 1k at 3.70 All I can say is thanks for the shares here.

  • Reply to

    3 by the close?

    by mannchris686 May 16, 2014 1:43 PM
    bigredkachina bigredkachina May 16, 2014 4:14 PM Flag

    I'm still here fairy.

  • Reply to

    I'm adding here

    by bigredkachina May 16, 2014 11:40 AM
    bigredkachina bigredkachina May 16, 2014 11:59 AM Flag

    I don't know about a jump back to 6 that soon in this environment, as all Bio and momo being repriced with this market. There are some definite bargains but have to choose carefully. Picked up a bunch of WYY this morning at open sub 1.30 Feel good about that and this below 4.

  • bigredkachina by bigredkachina May 16, 2014 11:40 AM Flag

    Picked up another 1k down here. Contenders and pretenders in Bio are all being painted with same brush. It'll shake out at some point. Run 'em, run 'em, deal 'em, deal 'em.

  • bigredkachina by bigredkachina May 13, 2014 10:02 AM Flag

    Validation and scaling. Getting the lab ready. This process is a slow one. Of course there could be a boom here. Lab Corp. McKesson. Illumina. Any one of those guys could take this thing out if the validation excites. Otherwise I see sideways pattern for the long term if we have to wait for Trovagene's CLIA to bring it to market.

  • bigredkachina by bigredkachina Apr 30, 2014 8:47 AM Flag

    There is always a reason and you will be last to know.

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