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Sanofi Message Board

biotech_invest 226 posts  |  Last Activity: Sep 12, 2014 2:08 PM Member since: Mar 5, 1998
  • biotech_invest biotech_invest Jul 24, 2014 11:39 AM Flag

    in simple words he got a payment from PRAN for data analysis and "right" conclusions.

  • biotech_invest biotech_invest Jul 24, 2014 11:35 AM Flag

    there are no any updates for earnings announcement. Aug 7 - Aug 8, 2014 is only estimated date.
    Definitely Mann will not go to earning press conf without "piece of pie" for MNKD investors. Question is how big this "piece of pie"?
    Partnership is not a simple and short process: partner will dig all trials data, ask about all doctor's comments and etc. When they know everything they will make an offer. 1-2 months minimal time. And now partner representatives on MNKD site.
    So any day morning we can see news. Most likely at the end of August.

    Sentiment: Strong Buy

  • it's not a theory but just hypothesis. And it's very one-side and poor one. Etiology of AD is still a puzzle.
    "The “amyloid hypothesis” is a prevailing pathological model of AD, accepted by most researchers.
    According to this model, the overproduction and accumulation of amyloid-beta (Aβ) peptides in plaques
    represent an early and central event in the pathophysiology of AD leading to the formation of neuritic
    plaques, whereas the cytoskeletal changes that arise from the hyperphosphorylation and intracellular
    aggregation of microtubule-associated protein tau to form neurofibrillary tangles are regarded as
    downstream phenomena."
    But if tau is a key to AD puzzle all drugs that act against amyloid should fail clinical trials. They did failed. All of them including PBT2.
    PRAN scientists want to fool investors with false statement that PBT2 "activates intracellular signalling pathways which promote neuronal health and plasticity and suppress pathobiological processes including the abnormal phosphorylation of tau". But it's lie because they never publish experimental data showing that the application of PBT2 decreases tau phosphorylation. It's very simple model experiment. Any post-doc can do it: Primary Rat Hippocampus Neurons + PBT2 Western of tau and p-tau Controls: 1) +inhibitor of tau hyperphosphorylation; 2) + inhibitor tau kinase
    If PBT2 suppress tau phosphorylation - bingo!

    "Mechanism of action of PBT2 in AD

    PBT2 prevents formation and toxicity of pathological Aβ species (primarily soluble oligomers) and promotes their clearance. In Professor Masters' presentation he proposes the observed effect upon amyloid burden is due to increased clearance by PBT2 of pools of PIB-detectable non-fibrillar soluble and membrane bound Aβ.

    Through its metal chaperone activity, PBT2 activates intracellular signalling pathways which promote neuronal health and plasticity and suppress pathobiological processes including the abnormal phosphorylation of tau.

    Sentiment: Strong Sell

  • Reply to

    rkf302 has 3732 posts for 1 year

    by biotech_invest Jul 23, 2014 5:41 PM
    biotech_invest biotech_invest Jul 23, 2014 6:15 PM Flag

    Cave? that is all you know?
    Old rats like rkf and eso are more funny than you, naive idiot.
    Well, it's already a happy hour so I should go
    Sciencefan, you must educate yourself and produce some clever posts here. Next time post something about AD etiology and PBT2 breakthrough in AD curing.
    Have fun, sciencefan!

  • Reply to

    rkf302 has 3732 posts for 1 year

    by biotech_invest Jul 23, 2014 5:41 PM
    biotech_invest biotech_invest Jul 23, 2014 6:05 PM Flag

    new member of your team? Teach him some manners :-) Look like that he too young and naive (just 9 posts)
    What is his role in your team? An admirer of Dr Shoulson and his huge achievements in HD area?

  • Reply to

    rkf302 has 3732 posts for 1 year

    by biotech_invest Jul 23, 2014 5:41 PM
    biotech_invest biotech_invest Jul 23, 2014 5:54 PM Flag

    just for fun, sciencefan :-) BTW, do you have something to contribute besides a..ki..ng and lickspittle?
    I'm posting what I want to post

  • Reply to

    Dr Ehud Arbit

    by larryharry2012 Jul 18, 2014 10:51 AM
    biotech_invest biotech_invest Jul 23, 2014 5:49 PM Flag

    may be they fired him
    there are too many terrible stories about Dr Wrong Side :-)
    But he knew all dirty secrets of EMIS oral drug delivery technology. Kidrons were fagged out him and throw out.

    Sentiment: Strong Sell

  • biotech_invest by biotech_invest Jul 23, 2014 5:41 PM Flag

    Excluding weekends he posts 15 posts per day. Bravo! Very productive pumper!

    3732 posts | Last Activity: 1 minute 51 seconds ago
    Member since: Dec 23, 2007

  • Member since: Jul 11, 2013
    Excluding weekends he posts 10 posts per day.
    Poor delusional guy that think that his posts will help to recover PRAN pps to $11-12 (where he bought it).

  • Reply to

    ah the delicious irony

    by rkf302 Jul 23, 2014 4:36 PM
    biotech_invest biotech_invest Jul 23, 2014 5:20 PM Flag

    Fresh pumper is arrived to help old farters? I like fresh ones
    Can say something clever? Something about AD mechanisms and role of zinc and other metals in AD pathogenesis?

    sciencefan2014
    9 posts | Last Activity: 1 minute 39 seconds ago
    Member since: May 11, 2014

  • Reply to

    ah the delicious irony

    by rkf302 Jul 23, 2014 4:36 PM
    biotech_invest biotech_invest Jul 23, 2014 5:02 PM Flag

    you are so funny guys with your stupid attempts to humiliate me :-)
    everybody who are reading your posts will see that you are completely senile. Even professional help will not help you, old farters.
    Continue, it's so funny :-)

  • biotech_invest biotech_invest Jul 23, 2014 4:57 PM Flag

    again just sophism and no direct answer :-)
    are you senile, eso?
    Question was: what are you did for mankind? But you are asking stupid questions
    BTW, head doctors are not exist :-)
    And when I said that I'm great? Can you cite my post with such statement?

    I have some time (between experiments) for posting here and some other MBs and I can't beat your phenomenal record of postings for 1 year:
    esoteric687
    2695 posts | Last Activity: 22 minutes ago
    Member since: Jul 11, 2013

    My record is very modest:
    biotech_invest
    190 posts | Last Activity: 44 minutes ago
    Member since: Mar 5, 1998

    You are posting 7 posts per day, I'm just 1 per 2 days

    And you are advising me "see a head doctor" LOL! You need it more than me :-)

  • My answer was:
    Eso, I see that you are a philosopher :-) Bravo for such sketch about my "miserable life"
    I have some list that I already did for mankind but just put my last achievement in medicine:
    "Cleveland Clinic: Early Detection of Inflammatory Bowel Disease"
    Chronic inflammation is a hallmark of the majority of diseases affecting humanity today, including atherosclerosis, multiple sclerosis, psoriasis, rheumatoid arthritis, asthma, and inflammatory bowel disease. Diagnosis often comes at a point when significant and irreversible damage has already occurred. The challenge is to identify a detection method that will allow for early diagnosis and treatment with sufficient time to adopt lifestyle changes or use agents to prevent or #$%$ disease development."

    Solved by me alone and I can prove it easy.

    Now it's your turn to say us what you did for mankind? Well, even without any proof.
    What you are? Ingenious entrepreneur? Company CEO or VP? Scientist who found some new cure for AD?
    We are all anonymous here but none of you pumpers can't prove that you have some brain. Just citing some stupid "metal theories" (BTW correct should be "metal hypothesis") and published papers that support this nonsense.

    he never responded on this question.

    So, Eso is philosopher but he is sophist. Sophists do not offer true knowledge, but only an opinion of things. They are always distorting and misrepresent truth and use stupid arguments like "you said sell PRAN at $1.47 and said pps will decrease to $0.27 but now PRAN pps is $2.37"
    Even if I ask very simple question like "was I right when predict PBT2 failure for AD and short PRAN at $11" they always answer absolute nonsense like "you actually spend time writing this krap. get a job"
    PRAN MB is interesting for me because of this bunch of well organized pumpers that want to mislead investors. Other biotech scam MBs don't have such harmonious teams of pumpers.
    Here I have a fun :-)

  • Reply to

    It was likely put some fire in a hornet's nest

    by biotech_invest Jul 23, 2014 11:09 AM
    biotech_invest biotech_invest Jul 23, 2014 12:50 PM Flag

    bashing? when?
    I'm just making money on biotech scam company but not hiding my opinion about "science" quality of PRAN. Same about CTIX - scam biotech but pps spike is possible very soon. So I bought it and wait. But CTIX is also in my Biotech scams list.
    incomprehensible bs are your posts here that claiming PBT2 as AD/HD cure.
    I can re-address your question to you: How much do you get paid for pumping?

  • Reply to

    It was likely put some fire in a hornet's nest

    by biotech_invest Jul 23, 2014 11:09 AM
    biotech_invest biotech_invest Jul 23, 2014 11:49 AM Flag

    Eso, I see that you are a philosopher :-) Bravo for such sketch about my "miserable life"
    I have some list that I already did for mankind but just put my last achievement in medicine:
    "Cleveland Clinic: Early Detection of Inflammatory Bowel Disease"
    Chronic inflammation is a hallmark of the majority of diseases affecting humanity today, including atherosclerosis, multiple sclerosis, psoriasis, rheumatoid arthritis, asthma, and inflammatory bowel disease. Diagnosis often comes at a point when significant and irreversible damage has already occurred. The challenge is to identify a detection method that will allow for early diagnosis and treatment with sufficient time to adopt lifestyle changes or use agents to prevent or #$%$ disease development."

    Solved by me alone and I can prove it easy.

    Now it's your turn to say us what you did for mankind? Well, even without any proof.
    What you are? Ingenious entrepreneur? Company CEO or VP? Scientist who found some new cure for AD?
    We are all anonymous here but none of you pumpers can't prove that you have some brain. Just citing some stupid "metal theories" (BTW correct should be "metal hypothesis") and published papers that support this nonsense.

  • AFREZZA is just simple insulin that is co-dried with special compound (so-called carrier or penetration enhancer; exactly fumaryl diketopiperazine) and become isolated from atmosphere oxygen in power form. Insulin alone quickly degraded even in powder form but if it co-dried with fumaryl diketopiperazine it is very stable. You can forget AFREZZA with cartridges in a car for entire summer day and use it without any problem. If MNKD make and test cartridges with basal insulin it will become an ideal insulin formulation for tropical climate like in India (may some China territories).
    Definitely, BLOCK BUSTER drug
    fumaryl diketopiperazine will also protect from heat-induced degradation GLP-1 peptide and other protein/peptide formulations. Big pharma should think about it.

    Sentiment: Strong Buy

  • Reply to

    It was likely put some fire in a hornet's nest

    by biotech_invest Jul 23, 2014 11:09 AM
    biotech_invest biotech_invest Jul 23, 2014 11:16 AM Flag

    catch 22: all paid pumpers always pick on a language :-) Gotcha :-)

  • All PRAN pumpers (esoteric687, rkf302, imtom9930 and other) are revealed themselves by attempts to sting me. They were protecting lead wasp-pumper i.e. Interestingtome that has 1029 posts and Member since: Jan 9, 2014
    Rfk302 was so pathetic and lickspittle when writing about Interestingtome’s "merits" on PRAN MB:

    "Interestingtome loser of 2014". By bio bubba
    A person who has worked every day investigating, researching information and sharing it. A person who went to Copenhagen and reported back information a loser. As opposed to a total douche who recommended you sell at 1.47 because it was going to 25 cents. Who is here to sell his expertise and cleverness. Except everyone. Every single person knows bio invest is a useless loser"

    BTW thanks for the compliment: “Who is here to sell his expertise and cleverness”

    Why not if people pay for my ideas? I’m just exercising my brain and get money for this. 10 awards at InnoCentive ( 130k) is not bad for simple ideation. I’m cracking challenges and I’m cracking science of biotech companies (both gems and scams). And I have paid for both.
    Who will pay for your stupid, pseudo-science posts on PRAN MB?
    Once again, I'm making money with both gem and scam biotechs but I never lie about what are these companies. If I'm trying make money on scam biotech I'm saying it in my twits (for example now it's CTIX-scam).
    If PRAN continue with AD it's doomed. And I will use it to make money. HD trial will induce better run up but it will also fail. I will also use it. And your pumping will help me to make money on PRAN-scam.

    Sentiment: Strong Sell

  • biotech_invest biotech_invest Jul 22, 2014 8:16 PM Flag

    this is correct - insulin is co-dried with special compound (so-called carrier or penetration enhancer; exactly fumaryl diketopiperazine) and become isolated from atmosphere oxygen. Insulin alone quickly degraded even in powder form but if it co-dried with fumaryl diketopiperazine it is very stable. You can forget AFREZZA with cartridges in a car for entire summer day and use it without any problem. If MNKD make and test cartridges with basal insulin it will become an ideal insulin formulation for tropical climate like in India and some China.
    Definitely, BLOCK BUSTER drug
    fumaryl diketopiperazine will also protect from heat-induced degradation GLP-1 peptide and other protein/peptide formulations. Big pharma should think about it.

    Sentiment: Strong Buy

  • Reply to

    interestingtome is Top Loser 2014

    by biotech_invest Jul 22, 2014 6:01 PM
    biotech_invest biotech_invest Jul 22, 2014 7:46 PM Flag

    meds? never use any meds and hope will not use them for a long time.
    What are you using for your cognitive decay? Are you hoping that PBT2 will help you? No way.
    I hope that you will be in right mind when AD will be approved.
    And how I can get losses with PRAN-scam? Used run up, sold at time and short at high - you have at least double gain with scam biotechs. With biotech gems you may have losses: CRL, FDA delay, dilution and etc. With scam never. So I will continue to play with PRAN-scam before final crash. And your pumping will help me.

    Sentiment: Strong Sell

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