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InterMune, Inc. Message Board

biotech_invest 113 posts  |  Last Activity: 7 hours ago Member since: Mar 5, 1998
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  • biotech_invest biotech_invest 7 hours ago Flag

    this is correct - insulin is co-dried with special compound (so-called carrier or penetration enhancer; exactly fumaryl diketopiperazine) and become isolated from atmosphere oxygen. Insulin alone quickly degraded even in powder form but if it co-dried with fumaryl diketopiperazine it is very stable. You can forget AFREZZA with cartridges in a car for entire summer day and use it without any problem. If MNKD make and test cartridges with basal insulin it will become an ideal insulin formulation for tropical climate like in India and some China.
    Definitely, BLOCK BUSTER drug
    fumaryl diketopiperazine will also protect from heat-induced degradation GLP-1 peptide and other protein/peptide formulations. Big pharma should think about it.

    Sentiment: Strong Buy

  • biotech_invest biotech_invest 7 hours ago Flag

    meds? never use any meds and hope will not use them for a long time.
    What are you using for your cognitive decay? Are you hoping that PBT2 will help you? No way.
    I hope that you will be in right mind when AD will be approved.
    And how I can get losses with PRAN-scam? Used run up, sold at time and short at high - you have at least double gain with scam biotechs. With biotech gems you may have losses: CRL, FDA delay, dilution and etc. With scam never. So I will continue to play with PRAN-scam before final crash. And your pumping will help me.

    Sentiment: Strong Sell

  • most stupid posts and huge losses with PRAN investment

  • Reply to

    Bio Dumba Bubba

    by interestingtome 9 hours ago
    biotech_invest biotech_invest 9 hours ago Flag

    Top Loser 2014 :-)
    imbeciletome will be better ID for you

  • biotech_invest biotech_invest 9 hours ago Flag

    nope :-) Name is Top Solver 2013 (and may be 2012) (InnoCentive).
    But you are definitely Top Loser 2014

  • Reply to

    one advice to PRAN believers

    by biotech_invest 15 hours ago
    biotech_invest biotech_invest 9 hours ago Flag

    LOL! "Your mind has nothing to contribute"
    I can easy prove that my IQ is higher than your. May be even doubled of your IQ.
    Eso, you are just stupid and senile pumper on PRAN MB. The reason of PRAN pumping might be very simple: put all your retirement money in PRAN stock and lose them. Now pumping and waiting to recover huge losses. Waste of time, old senile loser. Say good-bye forever to your money :-)
    You and your cronies will lose all your money with PRAN (hope you have real investment in PRAN-scam)

    Sentiment: Strong Sell

  • biotech_invest by biotech_invest 11 hours ago Flag

    Mann promised it after FDA approval and everything should be ready for filing. AFREZZA will be very popular in Europe. Next China and India ( 2B population together).

    Sentiment: Strong Buy

  • Reply to

    one advice to PRAN believers

    by biotech_invest 15 hours ago
    biotech_invest biotech_invest 11 hours ago Flag

    Come on, I have only 173 posts for last 3-4 years
    you, Vcaritas have 234 i.e. more than me

    And where is nonsense? Read my post dated March 12 (below). I did everything 100% correct: use PRAN run up for AD trial to have a gain and then shorted PRAN before trial results and got more gain.

    But all of you (PRAN pumpers) were 100% wrong about AD trial: it completely failed and even didn't show any amyloid decreasing in treated arm.

    Now you are trying to persuade investors to buy PRAN and wait again for $11 pps. It's ugly lie because PRAN drug will never cure AD. You just want higher pps because you got big losses and even can't use it for tax purposes. So you decoy naive investors in PRAN and wait for high pps to exit with minimal losses. Foul rats...

    biotech_invest • Mar 12, 2014 10:54 AM

    still don't understand? There is no any gap filling, it's just smart investors are selling this fake biotech and opening short positions. PRAN AD trial is doomed. After several buy/sell/shorts I finally shorted PRAN at $11 and will wait now before trial release. Will cover at $3 or below. This company is a fake biotech created to make money for "smart" scientists like Tanzi (believe me, shameless scientists can easy fool naive biotech investors; more examples: CTIX and NNVC).

    My last PRAN tweet: 03/06/14: shorted PRAN at $11 - AD trial will fail with probability 90% (no sign. difference in cognition decline between placebo and PBT2) Less
    Sentiment: Strong Sell

    Sentiment: Strong Sell

  • Reply to

    one advice to PRAN believers

    by biotech_invest 15 hours ago
    biotech_invest biotech_invest 14 hours ago Flag

    LOL! I'm so scared and already run :-)
    Who are you? Owner or Master of this MB? Nope, just stupid and stubborn pumper that lost money with PRAN investment and now hope that your lie will resurrect PRAN pps :-) No way.
    PRAN in my biotech SCAM list and I'll monitor it before final crash.
    I already helped some PRAN losers to recover when advised them to sell PRAN after crash and buy MNKD at $4. If they followed the advice they got 250% gain with MNKD (at $11.45 pps).
    Now MNKD pps might be doubled again. Use this opportunity and become rich. Or lose money with PRAN-scam.
    I was hoping for PRAN run up heated by HD but AD news were so stupid. I'm out but nor forever. Scam biotechs might be also very profitable.

    Sentiment: Strong Sell

  • sell PRAN and invest in real biotech gems like EDAP and MNKD
    PRAN executives lost the connection with reality: FDA doesn't care about brain volume they always want to slow cognitive decay (improving of mental status tests like ADAS-cog). PRAN continue to fool investors and all believers will lose money.
    Biotech is so profitable area for investment but investors should be clever and wise to separate fake biotechs from biotech gems.
    PRAN run up is finished and if you have some gain just sell PRAN and buy biotechs that will doubled in next couple weeks (MNKD, EDAP).
    GL

    Sentiment: Strong Sell

  • any time stock pps might be doubled (partner, acquisition, EMA filing, licensing in China and India and many other favorable for pps events).
    What is about downside? No partner, dilution, start product alone - pps can deep to $6 i.e. 30% from current. MNKD is not VVUS or AMRN because "one-puff" rapid acting prandial insulin miniature device will become world popular during 1-2 years. Bahsers want to scare MNKD investors via lies that suggested FEV1 monitoring of AFREZZA users is very expensive procedure and insurance will not cover it. Ugly lie: FEV1 is measured in one second (Forced Expiratory Volume in the first second) and measuring cost is negligible in comparison with other check-up procedures like blood analysis and even blood pressure measurement. The cost of miniature FEV1 spirometer is $39.99 and patients can measure FEV1 each day at no cost and save all data in device memory.
    Even if MNKD pps deep on no partner news to $6 it will recovered to $9 and up after EMA filing, lunch of AFREZZA and licensing to China and India.
    I'm buying MNKD back and will continue to do it before binary event.
    GL

    Sentiment: Strong Buy

  • biotech_invest biotech_invest Jul 17, 2014 2:13 PM Flag

    it's old Tanzi baloney about zinc
    no real experimental data that PBT2 decrease tau phosporylation. Once again it's one day experiment and simple Western blot result: phospho-tau before PBT2 application and after (below any house keeping protein like actin).
    In this paper I don't see any data showing that PBT2 decreases tau phosphorylation in neurons.
    Question is how PBT2 fight with hyperphosphorylated tau?
    Actually it's easy to measure tau phosphorylated at threonine 181 (ptau) in cerebrospinal fluid (CSF) of AD patients before PBT2 and after. Why PRAN never did it in phase II trial?

  • biotech_invest biotech_invest Jul 17, 2014 11:49 AM Flag

    tau but not Tau (without capital letter).
    if PBT2 attacks tau PRAN should show that tau phosphorylation is decreased after PBT2 treatment
    Do you have a link to published paper?
    In simple cell model (rat hippocampus neurons culture) it's very easy to show. One day experiment (beside 2 weeks to grow neurons).

  • biotech_invest biotech_invest Jul 17, 2014 11:44 AM Flag

    may be just brain swelling :-)
    who care about increase in brain volume without slowing cognitive decline?
    final will be vegetable with higher brain volume LOL

  • but it not slow cognitive decline. So many AD drugs already show decreasing of amyloid burden but all failed to show any slowing of cognitive decline.
    I think that PRAN will concentrate on HD but they continue with AD. Stubborn idiots.

    "In Professor Masters’ presentation, he noted that the starting amyloid burden level (baseline) in the
    PBT2 treated participant group had an important bearing on the decrease of amyloid over time in
    that participant (p=0.035), whereas there was no such correlation in the placebo group.
    Prof Masters further investigated the response of participants with baseline amyloid burden levels
    above and below the mean for the IMAGINE cohort (SUVR of 2.5). He showed that in the subgroup
    of PBT2 treated participants with a baseline of SUVR above 2.5, there was a significant decrease in
    amyloid burden that was not observed in participants on placebo nor PBT2 participants with a SUVR
    less than 2.5. In summary, whilst the utility of PiB in small trials may be questioned, it was
    interesting to note the impact of baseline SUVR amyloid burden level on the response of a cohort,
    for future trial design."

    "PBT2 prevents formation and toxicity of pathological Aβ species (primarily soluble oligomers) and
    promotes their clearance. In Professor Masters' presentation he proposes the observed effect upon
    amyloid burden is due to increased clearance by PBT2 of pools of PIB-detectable non-fibrillar soluble
    and membrane bound Aβ.

    Through its metal chaperone activity, PBT2 activates intracellular signalling pathways which promote
    neuronal health and plasticity and suppress pathobiological processes including the abnormal
    phosphorylation of tau. The trend towards reduced hippocampal atrophy seen in the PBT2
    treatment group mirrors the Company’s preclinical observations and reinforces a similar trend
    observed in the Reach2HD Huntington's disease study."

    Sentiment: Strong Sell

  • Reply to

    PBT2 works for AD - confirmed!!

    by pierreluke77 Jul 17, 2014 4:05 AM
    biotech_invest biotech_invest Jul 17, 2014 10:38 AM Flag

    are you complete idiot? Main goal for any AD drug is to slow (better stop) cognitive decline. FDA doesn't care about that AD patients treated with PBT2 will become vegetables with less atrophy of brain. May you need PBT2 to slow you brain atrophy?

    "Roche drug crenezumab failed to significantly slow cognitive and functional decline compared to placebo, missing two main goals"

  • biotech_invest biotech_invest Jul 16, 2014 9:06 PM Flag

    What is Walmart? Never was there
    I'm earning money only by thinking and creative ideation. And can prove it easy.
    What are you doing for life? Plumbing or cesspool cleaning?
    Too stinky :-)

  • biotech_invest biotech_invest Jul 16, 2014 8:14 PM Flag

    come on, I am resting now and have some drink (exactly Sandeman port). What you have? Some cheap whiskey?
    Give me something sharp :-)

  • biotech_invest biotech_invest Jul 16, 2014 7:58 PM Flag

    LOL! I just have so much fun reading your posts and comments
    Should pay you for writing of such funny rubbish. Please continue, imbetom :-)

  • Reply to

    all of you posting here are morons

    by kavinmilk Jul 16, 2014 7:29 PM
    biotech_invest biotech_invest Jul 16, 2014 7:52 PM Flag

    very brave statement:-) According to logic since you are also posting here you are also a moron.

    In philosophy and logic, the liar paradox or liar's paradox is the statement "this sentence is false." Trying to assign to this statement a classical binary truth value leads to a contradiction (see paradox).

    If "This sentence is false." is true, then the sentence is false, but then if "This sentence is false." is false, then the sentence is true, and so on.

    But may be you are right: posting here is waste of time but wasting of time is one of indications of morons.

ITMN
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