Wow, these "investors" are drinking the Koolaid and not wanting to hear anything bad about the ICPT cult.
Good point on irresponsible targets, there was good news but the pps reflects everything as a done deal, and its far from that. When a stock is priced to prefection, any hiccup sends it crashing.
There were several side effects which have been given little consideration. puritus, cholesterol change, etc.
Cost of producing the drug is the only one of your factors the company has any control over. The others are big question marks as we go forward.