You nor I can' read the tea leaves. Nor Can those clown bloggers
I have a very good understanding of Antisense Technology and its replication of trial results from pre-clinical models to actual clinical results. Clusterin biomarkers where measured after the first dose in the -011 Arm of the P2 studies and knocked down Stat Sig. The drug is active against this target.
The price or the volume has nothing to do with the tea leaves. I can point to dozens of Biotechs over the past 25 years my biotech investment horizon that did not move up or down before a Binary Event.
There has Never been any support from the street for OGXI. The way Management brought the company public via the utlization of another publicly traded biotech. #2) chemo has no future in prostate cancer, not true.
The FDA does not give out SPA;s nor Fast Track Designation unless their is meaningfull data/ medical need to back up the request. The reason for the SPA is to define a clear outcome and OGXI/ TEVA has agreed to that definition of what is STAT SIG and the steps to filing an NDA.
It sounds to me that they have two different paths and the second path utilizes the second -011 P3 trial results.
I for one don't know of one Biotech company that has disclosed the nitty gritty details of their SPA with the Public. Biotech CO's have no requirement to disclose the details only the fact that they had a meeting or got a letter and provide a very high level summary of the said meeting or letter about their communications with the FDA.
TEVA ownes -011 and controlls all communications to the investment community. OGXI is not free to say BOO without running it buy TEVA. Not to say that they don't have a good working relationship, they do one of the best I have seen. The worst I have seen is NBIX and Abbvie ...
If -011 is preceived by the Street as a failure or is an out right failure I will be a buyer on potential 427 results for bladder cancer. yes the stock will trade down to $3/$4 per share
Investor Village ISIS MSSG Board post # 44820
if investors listened to Dirk they would of not invested a plug nickle in ISIS
and volume has been significant over the past several weeks the stock PPS is up 80% from its November Low
I can remember days when 50K shares traded was a very good day
OGXI is not one of those 200M shares outstanding biotechs it has less than 15M shares outstanding
Volume trading days 200/300K are very very big days for OGXI.
And todays price action tells it all
Dirk is a side show that uses conjecture on his part to make some fringe points without the details to back them up. There is a nice post on the ISIS IV board by jetman that you all should read.
anyone who invests on his advise has their head stuck up their (_O_)
We are inside the 30 day window IMO for -011 P3 results
Given the trend OGXI should trade up to around $15/$16 whick equates to around a $250M MKT CAP
I'm in the $40 camp on positive P3 results because cancer has been a Hot biotech subsector and -011 has the potential to be a $1B drug. Chemo is never going to go away as a significant treatment for prostate cancer.
Sooner or later during a patients treatment cycle they will be on chemo thats what some sell-side analyst don't understand. I can see a variety of multiple drug cocktails that include -011
ASCO -011 presentation on P3 results no doubt a late breaking poster.
We get 427 results most likely June/July
Institutions will be loading up and their is only a small float
i have been waiting for it to fall thru $12 as $11.50 looks like the curent floor for support. since the catalyst are all 2H/14 events time is on the side of a lower entry point
Thats about a $55 PPS not unreasonable given OGXI has the option to co-promote OGXI-011 in North America.
On positive -011 P3 data next month IMO it will easily trade into the $40's as we will gain significant street coverage with 12 month PT's in the $60/$65 range. 427 P2 data is on deck for mid-summer.
or are we just going up in front of a Binary Event that will take OGXI into the $$$40's
don't let these clown poster scare you out of your shares as they are pathetic sprewers of dog dodo.
alias boxcarwhillie alias boxedout alias boxedin
We will trade over 7M shares today and the M-funds & institutions are loading up once again.
the funds don't want to be left behind on this one.
IMO, by August FY14 95% of the shares outstanding will be held by both insiders and the TUTES
I see MID $30's PPS in front of 520 P2a news
Sentiment: Strong Buy
they also stated ARWR will be worth $60 PPS if 520 P2a is highly positive ,,,,, Results expected in Q3/14
Sentiment: Strong Buy
Yes we will get a POP on the start of P1 for 520, but than it may ???? be time to sell trading shares.
I have both a Core and a trading position in a Roth IRA, Which I never ever have to pay any Taxes on my profits.
I have been waiting for $25+, don't know if I will get it on the POP.
No nothing untill after we get P2b proof of concept done in 2016
If positive we are talking F'n HUGE PPS
Enjoy the ride as I see $30 after P1 and $75 after P2a in early 2015, P2b ,,,,, $200+
you can take that to the bank
Just a reminder to everybody who thinks the trial results will be a flippen coin toss
This trial was conducted under an SPA, which always is bias towards stat sig results so IMO the survival p -value is a lot less than what was hit in the P2b trials.
boxcarwhillie alias boxcar, boxedin, boxedout ....................... lol
Sentiment: Strong Buy