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buddhaslackey 9 posts  |  Last Activity: Jul 28, 2015 9:07 PM Member since: Feb 27, 2005
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  • Reply to

    Interim Data for Phase 3 STS and/or Phase 2 SCLC

    by parisite76 Jul 28, 2015 10:25 AM
    buddhaslackey buddhaslackey Jul 28, 2015 9:07 PM Flag

    The method of action on THLD's drug is completely different from CYTR's. Both drugs, if approved, will ne synergistic in treating STS. In addition, THLD will be reporting out at the end of this year, not next year. Finally, THLD has a partner with Merck of Germany who is paying 75 percent of the trials so they are not burning cash as quickly as CYTR. I am long both stocks. Review the presentations by THLD as they clearly explain the two different methods of action.

  • Reply to

    STS Phase 2 vs EORTC data

    by mclim73 Jul 14, 2015 6:26 PM
    buddhaslackey buddhaslackey Jul 15, 2015 9:21 AM Flag

    Well, I can't get the entire excerpt to post. But age 50 is a significant threshold where patients have an inferior survival outcome and that could explain the differences between OS and PFS between the two trials.

  • Reply to

    STS Phase 2 vs EORTC data

    by mclim73 Jul 14, 2015 6:26 PM
    buddhaslackey buddhaslackey Jul 15, 2015 9:18 AM Flag

    Tumor stage was similar across different age groups. Younger patients (

  • Reply to

    STS Phase 2 vs EORTC data

    by mclim73 Jul 14, 2015 6:26 PM
    buddhaslackey buddhaslackey Jul 15, 2015 8:55 AM Flag

    For some reason, all of the excerpt did not post. Here is the conclusion to the 2011 study.

    Rhabdomyosarcoma was the only entity with a median age

  • Reply to

    STS Phase 2 vs EORTC data

    by mclim73 Jul 14, 2015 6:26 PM
    buddhaslackey buddhaslackey Jul 15, 2015 12:16 AM Flag

    I believe the age difference is a material difference between the two trials.

    Below are the results from a retrospective study.

    There were 48,012 cases that met the selection criteria. Individuals less than 20 years of age represented 5.6%, with rhabdomyosarcoma being the most common subtype. In adults, the most common types were Kaposi sarcoma, fibrohistiocytic tumors, and leiomyosarcoma. Rhabdomyosarcoma was the only entity with a median age

  • Reply to

    New 20k out

    by meltdownman1 Jun 24, 2015 1:16 PM
    buddhaslackey buddhaslackey Jun 24, 2015 3:40 PM Flag

    Is this statistically relevant? There are no statistics that are applicable. What can be said tis that spontaneous remission is extremely rare, by some estimates from one in 60,000 to one in 100,000. It should be noted that these are patients in this phase two trial who already failed treatment. So to have three of eighteen patients with a pathologically verified complete response seems to suggest a positive outcome. In other words, something is going on here that is not mere chance.

  • Reply to

    Modeling of 508 event for MAESTRO_Part 1

    by yinzhiqi May 12, 2015 3:19 PM
    buddhaslackey buddhaslackey May 29, 2015 12:54 AM Flag

    I give the STS trial a higher percentage of success because it includes maintenance therapy. There was no maintenance therapy in the Picasso trial. THLD reported updated data on November 15 2012. I believe the maintenance therapy is a data point that is mostly ignored when making comparisons to the Picasso trial.

    Sentiment: Buy

  • Reply to

    Modeling of 508 event for MAESTRO_Part 1

    by yinzhiqi May 12, 2015 3:19 PM
    buddhaslackey buddhaslackey May 29, 2015 12:40 AM Flag

    Review the PDF shareholder file on the THLD website:

    Study
    TH‐CR‐406:TH‐302 Phase 3 Trial in Patients with Soft Tissue Sarcoma
    Program Update

    You will see that the "recent historical data" refers to EORTC 92012 on page 3.

  • Reply to

    Modeling of 508 event for MAESTRO_Part 1

    by yinzhiqi May 12, 2015 3:19 PM
    buddhaslackey buddhaslackey May 28, 2015 4:50 PM Flag

    The Picasso trial had nothing to do with the expanded patient enrollment. Rather it was the EORTC 62012 trial which resulted in the expanded enrollment. One must remember that in the EORTC trial, patient enrollment was limited to those sixty years and younger. So this was a younger population which, perhaps, could explain, in part, the improved overall survival.

    Sentiment: Buy

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