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Insmed Incorporated Message Board

checksurshorts 30 posts  |  Last Activity: Feb 8, 2016 2:40 PM Member since: Dec 1, 2006
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  • Reply to

    Informal poll......is iPlex a farce??

    by insmhistorian Nov 17, 2015 5:18 PM
    checksurshorts checksurshorts Nov 17, 2015 9:21 PM Flag

    2014: "Diabetes-induced changes in growth factor binding protein 3 (IGFBP-3) and tumor necrosis factor alpha (TNFα) have been linked to decreased insulin receptor signaling in diabetic retinopathy. Our previous studies in retinas of diabetic rats have shown that Compound 49b, a novel β-adrenergic receptor agonist, prevented diabetic changes by increasing IGFBP-3 and decreasing TNFα, thus restoring insulin signaling and protection against diabetic retinopathy. The current study was designed to determine whether boosted expression of IGFBP-3 NB (a non-IGF-1 binding form of IGFBP-3) alone is sufficient to mimic the full actions of Compound 49b in protecting against diabetic retinopathy, as well as testing whether IGFBP-3 NB is linked to a restoration of normal insulin signal transduction. Two months after initiation of streptozotocin-induced diabetes, rats received a single intravitreal injection of IGFBP-3 NB plasmid in the right eye. Four days after injection, electroretinogram (ERG) analyses were performed prior to sacrifice. Whole retinal lysates from control, diabetic, diabetic + control plasmid, and diabetic+ IGFBP-3 NB were analyzed for IGFBP-3, TNFα, suppressor of cytokine signaling 3 (SOCS3), and insulin receptor signaling partners using Western blotting or ELISA. Data show that a single intraocular injection of IGFBP-3 NB in diabetic animals significantly reduced TNFα levels, concomitant with reductions in IRS-1Ser307, SOCS3, and pro-apoptotic markers, while restoring insulin receptor phosphorylation and increasing anti-apoptotic marker levels. These cellular changes were linked to restoration of retinal function. Our findings establish IGFBP-3 as a pivotal regulator of the insulin receptor/TNFα pathway and a potential therapeutic target for diabetic retinopathy."

    Sentiment: Strong Buy

  • Reply to

    Informal poll......is iPlex a farce??

    by insmhistorian Nov 17, 2015 5:18 PM
    checksurshorts checksurshorts Nov 17, 2015 9:22 PM Flag

    2014 Apr 2;9(4):e93788. doi: 10.1371/journal.pone.0093788. eCollection 2014.

    Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina.

    Sentiment: Strong Buy

  • checksurshorts by checksurshorts Nov 24, 2015 2:33 PM Flag

    Associate/Director, Clinical Operations - EU
    Frankfurt, Germany

    Sentiment: Strong Buy

  • checksurshorts by checksurshorts Nov 27, 2015 12:05 PM Flag

    "I participated in the Arikayce trial in 2013. I had taken the big 3 plus Clofazamine since 2007. (Clofazamine added in 2012) and continued to culture "heavy growth," though I had a great tan. After participating in the Arikayce trial starting in May of 2013, I have cultured NEGATIVE since then. I highly recommend participating in this trial if you qualify. Please feel free to contact me with questions on my experience..."

    "When I was inhaling the Arikayce which is a liposomal form of Amikacin, I was in a clinical trial. The special nebulizer and the Arikayce was supplied for the period of time I was part of the study. I am not inhaling Arikayce or Amikacin now. I stopped when I had completed the study. This was in late 2013. I have continued
    to culture negative for MAC / NTM since I completed the study. I would recommend you contact the following to get more information..."

    "...I have though inhaled Amikacin with saline solution probably about 5 years ago as I was not responding to the cocktail of three antibiotics. My vocal chords could not tolerate the Amikacin mixed with saline solution. I
    would completely lose my voice and I was in sales at that time. Some people can tolerate it but often it is problematic. I could tolerate the investigational drug Arikayce though I did have a "sexy" raspy voice while in the trial. The good news is that since then I have cultured negative for NTM. I am keeping my fingers crossed I stay that way..."

    Sentiment: Strong Buy

  • checksurshorts by checksurshorts Nov 27, 2015 12:13 PM Flag

    From NTMir: "Webinar: NTM - Critical Updates & Strategies to Address this Emerging Hospital Pathogen

    Pall Medical invites you to attend a webinar presented by Dr. Joseph Falkinham, a nationally and internationally recognized expert on Mycobacteriology. With today's critical need to ensure patient safety and reduce Hospital Associated Infections (HAIs), it is more important than ever to address the increased rate of infections associated with waterborne pathogens like NTM. This timely webinar will examine scientific evidence linking NTMs to HAIs and help you gain a better understanding of the consequences for high-risk patients as well as introduce optimal prevention strategies. *Continuing Education credit is available."

    Sentiment: Strong Buy

  • Reply to

    NTM Webinar

    by checksurshorts Nov 27, 2015 12:13 PM
    checksurshorts checksurshorts Nov 27, 2015 12:16 PM Flag

    "With today's critical need to ensure patient safety and reduce Hospital Associated Infections (HAIs), it is more important than ever to address the increased rate of infections associated with waterborne pathogens like NTM. NTM are environmental opportunistic pathogens living in hospital drinking water distribution systems and premise plumbing. Their high adaptability to hospital plumbing creates several sources of infection including showerheads, faucet taps, hot water heaters, therapy pools, hydrotherapy hoses, and ice machines/water dispensers. This timely webinar will examine scientific evidence linking NTMs to HAIs and help you gain a better understanding of the consequences for high-risk patients as well as introduce optimal prevention strategies.

    Learning Objectives:
    • Learn what NTM is, how it spreads, where it lives, and where it comes from.
    • Examine evidence linking NTMs to HAIs and the high-risk areas in hospitals where NTM has major consequences.
    • Prevention strategies to address NTM."

    Sentiment: Strong Buy

  • Reply to

    New NTMir Posts

    by checksurshorts Nov 27, 2015 12:05 PM
    checksurshorts checksurshorts Nov 27, 2015 2:20 PM Flag

    Clone

    Sentiment: Strong Buy

  • Reply to

    NTM Webinar

    by checksurshorts Nov 27, 2015 12:13 PM
    checksurshorts checksurshorts Dec 10, 2015 11:27 AM Flag

    This is today.

    Sentiment: Strong Buy

  • Reply to

    New NTMir Posts

    by checksurshorts Nov 27, 2015 12:05 PM
    checksurshorts checksurshorts Dec 16, 2015 7:02 PM Flag

    Bump

    Sentiment: Strong Buy

  • Pfizer is buying Allergan but since Allergan is domiciled tax-friendly Ireland, the deal is structured in a way that it basically has Pfizer as being bought by Allergan. That way Pfizer will now be based out of Ireland and avoid high US corporate tax rates.

    How much is this deal worth to Pfizer based upon tax savings alone?

    Since Insmed is domiciled in Ireland as well, does this make it a more attractive take-out target and will a future deal be structured in the same way as the Pfizer deal? Assuming the next Prez has a (R) next to his or her name of course.

    Sentiment: Strong Buy

  • Reply to

    Will Insmed be "buying" a large pharma?

    by checksurshorts Dec 16, 2015 10:25 PM
    checksurshorts checksurshorts Dec 17, 2015 9:50 AM Flag

    Good point. See "The High Cost of Stupidity" by Kevin Williamson at National Review, posted yesterday and still up.

    Sentiment: Strong Buy

  • Reply to

    New NTMir Posts

    by checksurshorts Nov 27, 2015 12:05 PM
    checksurshorts checksurshorts Jan 7, 2016 12:58 PM Flag

    Bump

    Sentiment: Strong Buy

  • Reply to

    New NTMir Posts

    by checksurshorts Nov 27, 2015 12:05 PM
    checksurshorts checksurshorts Jan 7, 2016 2:23 PM Flag

    Why don't you go to NTMir yourself, sign up and tell this directly to the patients who have experienced the same things trial results have conformed?

    Sentiment: Strong Buy

  • Reply to

    New NTMir Posts

    by checksurshorts Nov 27, 2015 12:05 PM
    checksurshorts checksurshorts Jan 8, 2016 8:48 PM Flag

    Bump

    Sentiment: Strong Buy

  • Reply to

    Scared?

    by farmboyva Jan 13, 2016 2:39 PM
    checksurshorts checksurshorts Jan 13, 2016 3:07 PM Flag

    1000 thumbs up

  • Reply to

    Our golden opportunity

    by jsblvbjb Jan 20, 2016 10:49 AM
    checksurshorts checksurshorts Jan 20, 2016 11:03 AM Flag

    About 1/3 of our current market cap is cash in the bank. LOL

    Sentiment: Strong Buy

  • checksurshorts by checksurshorts Jan 20, 2016 4:03 PM Flag

    "At 1245ET, someone decided that the shorts had done enough damage and investors suddenly rushed "flight to safety"-like for the GPROs, TWTRs, FITs, and Biotechs of the world. This unleashed a massive short-squeeze among the "most shorted" stocks..."

    "And Biotechs are soaring back into the green..."

    Sentiment: Strong Buy

  • Reply to

    Our golden opportunity

    by jsblvbjb Jan 20, 2016 10:49 AM
    checksurshorts checksurshorts Jan 20, 2016 4:12 PM Flag

    Unless they suddenly (EU decision) become unspeculative.

    Sentiment: Strong Buy

  • Reply to

    Our golden opportunity

    by jsblvbjb Jan 20, 2016 10:49 AM
    checksurshorts checksurshorts Jan 21, 2016 9:38 AM Flag

    I know, which is why I would be laughing even louder if we were trading below cash in the bank.

    Sentiment: Strong Buy

  • Reply to

    BO rumor of MDCO a Phase II trial company

    by justarook04 Jan 22, 2016 9:57 AM
    checksurshorts checksurshorts Jan 22, 2016 11:03 AM Flag

    Hey #$%$ clown...you are a clone!!!

    Sentiment: Strong Buy

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