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Curis, Inc. Message Board

chinesehamsters 8 posts  |  Last Activity: Oct 13, 2014 6:20 PM Member since: Sep 24, 1999
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  • chinesehamsters chinesehamsters Oct 13, 2014 6:20 PM Flag

    Way back before Kadcyla obtained its first approval I had been watching this company and bought into it based on the strength of the clinical data as it became available. My cost basis was around $7. I made the right decision to set the money aside and go back to cash when we were around $12ish. The current weakness aside from the overall market makes me wonder if there is another secondary offering in the works. Higher roylaties from Kadcyla are still further out, and licensing fees are not just flying off the shelves either. I will continue to sit on the side lines, but at some point this has to become such a compelling value that some one buys them, or the alternative is the board has no choice but to get rid of Junius. Not even those fat cats can justify keeping this current manamgement in place.

    Chinese Hamsters

  • Reply to

    Poor Charlie's financial hardship

    by bioimmunomabman Sep 30, 2014 3:00 PM
    chinesehamsters chinesehamsters Oct 2, 2014 12:21 PM Flag

    Really, they are giving Morris $125K to help defray the costs of a 2nd residence in Mass where the company headquarters is located, while he keeps his primary residence in Pennsylvania. So isn't that his choice? Do they offer that kind of housing assistance to all of the employees, umm no. Is Morris so remarkable that he should be catered to? I have not seen anything remarkable about him. I have not seen anything remarkable about any of the IMGN leadership team. These guys are like vampires sucking the company drie until it is a corpse.

    Off topic. The Ebola situation and that is has shown up in the United States now may provide some unique investment opportunties. Look over some of the players in that space. The FDA has a special situational path to approval for drugs in early stages of development that will allow human use pretty much without going through any clinical trials. I think it is termed the animal model, they can do a safety and dose escalating study in monkeys and if that looks OK they can proceed directly to human use. Sad that a situation like this has to develop to focus all the resources needed to curb this disease.

    Chinese Hamsters

  • chinesehamsters by chinesehamsters Sep 25, 2014 3:58 PM Flag

    I have paired back to nothing in Immunogen at this point. I also liquidated several other positions this week as it seems the market is choppy at best, and today gives us an idea of how quickly things can go south. I will continue to watch and gauge Kadcyla progress, but I'm not going to leave that many eggs in one basket. As has been said many times, this is a very impressive technology but the management in this company is exceedingly poor. I don't know why they cannot ink a biz development deal with such a powerful technology, so that has to tell you something more about this management team. Good luck on this one folks.

    Chinese Hamsters

  • chinesehamsters by chinesehamsters Aug 22, 2014 12:29 PM Flag

    The ADC technology this company has is one of the most impressive new developments in biotech than I have seen in years. Unfortunately it is in the hands of a bunch of embiciles that have been unable to ink a meaninful deal with anyone in the last couple of years. What looked like a very promising investment has turned into dead money for me. So its time to fold up the tent and move on for me. I may keep a few thousand shares, but I have allocated way to much into this one holding.

    Not only are these fools doing nothing to generate any new biz, but it also looks like we are starting to see significant pushback from reimbursement/insurance regulators also. To them, it does not matter what the drug can do for a patient if it costs more than they are willing to pay. For that reason, Kadcyla's growth may be limited. We are still a few years out from seeing the label expanded for Kadcyla as a result of the ongoing clinical trials. We cannot blame the current management for the royalty structure for Kadcyla, but that is also working against Immunogen as well. I sincerely hope that Immunogen get's aquired so that this ADC technology can truly be put to use and create some meaningful new drugs. Too bad you cannot sell covered calls in a 401K as I would use that to move out of this investment.

    Chinese Hamsters

  • Reply to

    Earnings expectations?

    by afro_bro_bro Jul 28, 2014 1:23 PM
    chinesehamsters chinesehamsters Jul 28, 2014 3:53 PM Flag

    I keep seeing that comment here, that Kadcyla is dissapointing because Perjeta sales are so much better. Currently Perjeta is approved for two indications in combination use with Herceptin. Kadcyla is currently approved to treat HER2-positive breast cancer that has spread to other parts of the body (metastatic breast cancer) after prior treatment with trastuzumab (Herceptin®) and a taxane. Prior treatment could have been for the initial treatment of breast cancer or for the treatment of cancer that had spread to other parts of the body. So it should not be a big surprise that Perjeta is currently outselling Kadcyla, just due to the approved indications and thus what oncologists can prescribe within the label.

    If you go to clinical trials.gov yo will see over 40 trials for Kadcyla. The big trial (MARIANNE) ongoing is in 1st line MBC, and that trial has one arm with Kadcyla plus Perjeta. This is the indication that will put Kadcyla on the map and open up earnings considerably. We should see some data in 2014, but the trial is not scheduled to end until April 2016. So just sit back and wait.

    Chinese Hamsters

  • Reply to

    I'm feeling a good vibe somehow

    by slumdawg2011 Jul 18, 2014 12:34 PM
    chinesehamsters chinesehamsters Jul 18, 2014 3:09 PM Flag

    I don't have the confidence in the IMGN management to monetize the full potential of Kadcyla sales. They may monetize on a peak sales of $5 billion rather than the $9 billion that will eventually materialize.

    Chinese Hamsters

  • Reply to

    Seriously, #$%$?

    by chinesehamsters Jul 16, 2014 2:46 PM
    chinesehamsters chinesehamsters Jul 16, 2014 4:48 PM Flag

    A press release noting the granting of orphan drug status for a molecule would not be material if they were in talks of being bought out. I am not buying that for an excuse. I hope they do get bought out, anywhere between $15 - $20 a share. That way I don't have to watch their miserable performance any longer.

    Chinese Hamsters

  • chinesehamsters by chinesehamsters Jul 16, 2014 2:46 PM Flag

    The drug given orphan drug status is most definately their folate targeting ADC 853, which is wholly owned by Immunogen. Is it that much effort to put out your own press release? At this point even this board of directors has to be getting tired of this #$%$. Junius should just resign or kill himself. I never thought this company would still be floundering in 2014 with such an impressive technology at their disposal. I wonder what those 10 or so biz development people do with their time. This is just hard to watch anymore.

    Chinese Hamsters

CRIS
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