We already have pre-Approval PT's of about $48. So now with APPROVAL many analyst will start to increase their price targets and recommend Strong Buy or Out preform or Over weight etc, Thinking $65-75.
Is this some kind of joke...Spader is some kind of finance guy, I am a retire physician and paidpumpers works at 7Eleven night shift. He lives in his grandmother's basement. Surprised you can't figure that out.
I think number 1. will give us an idea of expected rev's. I noted this in one of the new articles, " The drug, Nuplazid, is expected to be priced at $13,500 per patient for a year and reach more that $1 billion in sales in 2021, according to Leerink analyst Paul Matteis."....
Had a patient, elderly lady with AD bought in by a somewhat younger man. She told me he stole her dishes and she kept calling him "honey ". When I spoke with him later he tells me she is his mother , but thinks he is her husband. He had to move her into his house but moved a lot of her things into a storage unit.
Well, I didn't say the mechanism is the same...I really don't know that but I suspect it is similar.
Ask a Psych. But in general Hallucinations can be similar in those 3 conditions. An illusion is like a miss interpretation, (?)...looking at hot pavement and it looks like water. Maybe you mean is a delusion? A false belief....I believe the CIA is out to get me, they are tapping my phone and put a GPS device in my brain and no matter what you tell me I have an answer re-enforcing that belief.
He didn't have a clue how to take the company to a NDA. He had it all wrong and he lied to the shareholders and most likely told MIlls and Davis to lie too at a Q Rept. He told us the NDA was " on track ", knowing full well there were several deficiencies with the QA manufacturing that certainly would have resulted in a CRL. The BOD dumped him and the stock killed the share holders, it dropped from like $29 to like $15- puke level. Yeah thanks Uli...
1) How much will the medication cost, ie 30 day supply, 60 tab bottle should be close to $1000. That would be $12,000 per yr.
2) How many months till the NDA is filed in the EU ?
3) Is there an ongoing search for a partner?
4) Update on other trials.
You and your wine, are you like an expert wine guy...I forget what they call those people that are expert tasters. Gotta friend who is one...
Ah....that's not nice and threats like that could be consider illegal, they are taken very seriously. If I were you I would remove your post before you get reported.
"" According to the National Parkinson Foundation, about one million people in the United States and from four to six million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, which is characterized by hallucinations and delusions, is associated with significant caregiver burden, and is a major reason for nursing home placement among Parkinson’s patients. ""
So we have an ineradicable potential. Not even counting Off Label. Lets say in approx 2+ yrs, consider a 20% penetration = 480,000 patients (=6Mil x 40%PDP x 20% penetration) ...x $10,000/yr/patient ( low guess, I usually say $15,000 per yr./patient), then we are talking ... OMG... $4.8 Billion/yr Rev's. Holly $hit .
Most likely a NDA will be within 6 mos. My guess, in the past they said 9 mos after approval, but somehow I think now they will move it up.
WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS
See full prescribing information for complete boxed warning
Elderly patients with dementia
-related psychosis treated with
antipsychotic drugs are at an increased risk of death.
NUPLAZID is not approved
for the treatment of
related psychosis unrelated to the hallucinations and
delusions associated with Parkinson’s disease
Granted the FDA is just summarizing their BB above, it will probably be much longer and in BIG BOLD SCARY TYPE. They are trying as hard as they can to discourage doc's from using Nuplazid for Off Label use. The effect of a BB Warning will decrease with time as Doc's gain confidence with the Low SAE and comfortable using the drug.
"" Nuplazid has a Boxed Warning alerting health care professionals about an increased risk of death associated with the use of these drugs to treat older people with dementia-related psychosis. No drug in this class is approved to treat patients with dementia-related psychosis. "" ...
Here's my guess - A Black Box Warning - " WARNING: DUE TO INCREASED MORTALITY IN ELDERLY PATIENTS, Physicians are cautioned to restrict use only in patients currently being treated for diagnosed Parkinson's Disease who develop psychosis due to Parkinson's Disease ONLY. And only when the benefit of treatment out weighs the risk of the listed side effects including death. " Off label use of Nuplazid has not been studied and is strongly discouraged due to placing the patient at undue risk.