Alzheimer's Disease is one of the most complex disease to understand. That is why so many drug studies have failed. It is important to attempt to understand some of the complexity - start with the
Corporate Presentation ( http://www.anavex.com/files/Anavex_Presentation_May_2015.pdf ) esp pages 5, 6, and 7. Then listen to the web cast. These are all found on the home page. BTW "CHO " stands for Chinese Hamster Ovary cells.
The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with mitochondria whereby the contact isreferred to as the mitochondrion-associated ERmembrane or the MAM. Here we found that the MAM regulates cellular survival via an MAM-residing ER chaperone the sigma-1 receptor (Sig-1R) in that the Sig-1R chaperones the ER stress sensor IRE1 to facilitate inter-organelle signaling for survival. IRE1 is found in this study to be enriched at the MAM in CHO cells. Wefound that IRE1 is stabilized at the MAM by Sig-1Rs when cells are under ER stress. Sig-1Rs stabilize IRE1 and thus allow for
conformationally correct IRE1 to dimerize into the long-lasting, activated endonuclease. The IRE1 at the MAM also respondsto reactive oxygen species derived from mitochondria. Therefore, the ER-mitochondrion interface serves as an importantsubcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria,ER, and nucleus
Several things...the most common cancer in the world is not on your list=Prostate Ca. It is the most common because it can be diagnosed early with the PSA test. If you are 40 years old you should be getting yearly PSA and digital exams. There are many treatments. If you get it, you are more likely to die with it, then to die from it. But there is a small % of these Prostate cancer patients who seem to have very aggressive disease. Fast growth ,fast spread and fast death. Also there has been some 120 studies in Alzheimer's in the last 10 yrs and all basically failed, till AVXL.
BTW this is my favorite part. "Lincoln Park Capital has agreed not to cause or engage in any manner whatsoever, any direct or indirect short selling or hedging of Anavex’s shares of common stock."
PRAN is way different approach ( looking to treat some accumulation of ? copper-).. ...I doubt they will succeed. Listen to the AXVL Qrpt, I believe its on Monday. Good luck.
Blaming the market may make you feel better but I believe we wouldn't be this far down if we had a better CEO. He has no guts, lied and most likely folded like a lawn chair when Uli told him to lie or to keep his mouth shut. He is a weak CEO and weak in belief in the truth. Give me someone, man or women who stand their ground and really believes in a strong aggressive approach that will knock your socks off. Davis ain't that guy. Davis is the CEO and has to own the " uncertainty" that is crushing this stock.
Do your DD over the weekend. Breakthrough drug for Alzheimer's Dis. Huge market, about 65 Bill ( that's with a B). $1.23 at this time, once it runs you won't be able to touch it. Solid science. Incredibly complex disease where other companies studies have failed for the last 10 yrs.
Major Breakthrough drug Anavex 2-73 for the biggest market in biotech- 65 Billion, Alzheimer's disease - disease modifying and treatment of cognition deficit.
They could have hired one of several excellent well seasoned CEO's but no, keeping Davis was and is a huge MISTAKE. I said this soon after Uli "retired". It shouldn't have taken more than a few months of searching. This is what is killing this stock at this time. Davis is very defensive, what we need is a very aggressive CEO. Dump Davis NOW. Its not too late.
“Take all you can eat, warm your body with these gifts, share them among your loved ones. Drink the water till your thirst is quenched, eat the sweet fruits. All is for you. I give to you all your heart desires, to live, breathe, and walk in my forest. Sing and loudly rejoice, for your pain shall be soothed and your hunger satisfied with my gifts. Have all. But use all like a poor man spends his pennies, not as a king spends his gold. Listen to the heart of the green forest, the meadows, streams, and animals. Blessed is he that takes what he can eat and no more. Blessed is he the most that returns with a gift in thanks.”
Christopher U. Missling, MS, PhD, MBA
Dr. Missling, President and CEO of Anavex, has over 20 years of healthcare industry experience within large pharmaceutical companies, the biotech industry and investment banking. Prior to joining Anavex, he served as the Chief Financial Officer of Curis and ImmunoGen. In addition, at Aventis (now Sanofi), Dr. Missling worked as head of financial planning on all aspects of financial strategy and M&A. His career experience also includes working as an investment banker in the healthcare practice at Deutsche Bank, serving pharmaceutical, biotech, and diagnostic companies, as well as serving as the head of healthcare investment banking at Brimberg & Co. in New York. Dr. Missling has an MS and PhD from the University of Munich in Chemistry and an MBA from Northwestern University Kellogg School of Management.
" ANAVEX 2-73 also shows SYNERGISTIC activity with three generations of epilepsy drugs currently on the market: ETS (Zarontin ®), VPA (Depakene®) and Gabapentin (Neurontin®) "
Know the Phases of Shorts
1) Bragging about their position
2) Posting misleading or unsubstantiated info
4) Quiet Covering. .............# 3) is key, alerts you they are close to covering.