There have been more than 82 antisense compounds that have entered the clinic in over 130 indications, with Isis as sponsor or licensor of approximately two-thirds of these. Despite this massive R&D effort, only a two products have been approved for marketing by the FDA. They have received a very narrow label and have smaller sales. I believe most of the small investors in Isis are quite gullible and may live in the young age of entitlement. I wish them all the best ! I also hope Isis succeeds in helping humanity with non-toxic antisense oral treatments. Remember, antisense has no cure for any disease and is large molecule. Problems with antisense therapy do exist to this day. I could go on & on.
Yes, I still hold Vical and recently have added a large amount for my family. I've always stated, " be careful investing in biotechnology companies as all are risky'. Good luck all & hope for the best.
Said results were not sustained and remain yet to be validated such as the antisense technology. Let's hope for the best !
Have a great day my friends !
Hi my friend Jetman.
This is so unlike you and I wish you well. I purchased VEEV last week, BMY, AGEN and GNCA. This morning I reminded a few of our followers of certain Vical assets such as Vaxfectin. Astellas is happy with their collaborations with Vical while paying the freight moving forward. BMY is researching Vical's Vaxfectin as I speak. The group is waiting for an Isis buyout in vain, however, the rumors persist enough to move the stock price up without a safe antisense drug. Yes, I have to hand it to Dr. Crooke's what appears to be smoke & Mirrors tactics. Hang in there ... wish you good health & success !
Oh yes and a note of good cheer to the loyal flock of Isis promoters... on Oct. first to the third 2014 Big Stan threw out 55,000 more Isis shares that he received for failing the last 25 years. Super sad but the Isis victims love it. More dilution on the way.
HARVON is the safe treatment answer for Hep-C & Liver damage ! Folks, seldom do I scan this board other than once a week in a limited manner. The psychotic Isis hypsters on this board who use or contribute in my name are humorous. Yes, I still like VICAL and ISIS and hope for the best for both, however, I have the most of my investments in BMY, CELG, MRK, LILLY & AMGEN.
Good health to all... from Darkouttonight.
Nothing has changed... no validation of antisense...Same hyping of nothing new. I still hope for the best with Isis & Vical. ! Good luck all!
Makes for interesting reading. Vical is hitting on all eight at this time. I wish all Isis & Vical investors good luck. Enjoy the summer!
Hello my friend jetman.
Nice to hear from you... actually I own a bit of AGEN too. However, they can't hold a candle to Vical if you look deep into Vical's technologies. I believe AGEN will be bought out by the latest next year at this time. Vical will most likely be grabbed by one of three "big pharma" companies too. I see where this antisense company also will have to be merged due to old shorty fast growing weaker. Shorty, has milked the Isis cow to the dark extreme end of the no revolutionary story. He can only beg for a break through so many years before the true validation of a round antisense peg will not fit in a square hole.
In the mean time stay healthy. : )
I'm working on Micelles (PMS) at this time. Isis's lack of oral delivery is keeping their scientist going double time to correct this serious flaw relating to Antisense. Dr. Crooke stated he had the oral delivery problem solved in 1999 with the Elan collaboration... of course that was not true. I don't have the time to convince or engage the genius who is very angry at my exposing the flaws of Antisense drugs.
I Wish you & them luck with a chuckle & chortle. : )
Also, have added over 100,000 Vical shares since last Oct. under $1.45. Please, do your own DD on Vical as it's not as easy to predict as Antisense advanced chemical modifications are clear to me! Remember, all biotech companies are very risky!
Have a pleasant weekend . Chuckle. : )
This morning I took a minute to listen to the motley silly dialogue promoting the Isis pipeline. " Isis has more home runs " in the future. " I don't want to get into the science." Sorry folks , Isis has never had an Antisense phase 3 clinical trial home run ! So, you two Isis motley propaganda rascals, "Don't want to get into the science" of dark antisense Isis drugs? Why not ? I'd love to debate you both on why Antisense drugs have failed to be viable since 1984.
Newbies, be careful. I too hope that some future time Antisense drugs will work safely, however, that day has yet to come. : (
Today was a rerun of your 1997 PR. Sad. These trials still highlight several toxicities that are attributable to the chemical structure of the AOS. Stan, you and your friends have taken so much wealth out of Isis why don't you do the right thing and let the poor stockholders reap their just rewards? Your muttering on TV disguised some of the truth that should be clearly stated with regard to the long tract record of Isis's failing pipeline. Not to mention the lack of even one viable antisense drug on the market in the history of antisense drugs to 1984 ! I could go on & on as I've explained in the past 15 years... why bother. There is a higher power Stan ! Stan, did you hear that buffoon sound off in the end of your interview?, "Isis is a great company !" Yes, a great company that the buffoon can change his mind on again & again with newbies hard earned money.
Good health to all.
Yes, it will be stated , tolerability & safety good and the preliminary anti-tumour activity will be positive. I don't understand why it's call "Next generation", it's not new. ZZZZ
Anti-VEGF Therapy... anything new since 2012 ? I don't believe the topical application of eye drops will hurt and actually may help patients. Hope for the best. BTW, all is well at Vical for a very good 2014-15-16. This year you may hear positive partnering with Vical and large pharma. My prediction in January is right on schedule... hang in there Jetman !
Interesting. RNN with Brinson Patrick too.
Thanks for your support . The back off of the Isis stock price facing the darkest days from January 2014 to now was a no brainer as there had been no end to the possibilities and imaginations hyping antisense for a year plus. It's a fact that Isis has never produced one viable large scale p-3 successful clinical trial antisense drug in 25 years. Yet, reading their press releases the average fund manager would think that Isis owned the Holy Grail of disease treatment. That would be nice but not true... not even close. The serious problems with Antisense so- called drugs exist after all of these years. Cheers to you and Vical... I think you both will do fine. Good health to you. : )
Good to know you're doing well. : ) I like your humorous dark Vical post . I voted down Vical's proposed compensation reward for insiders. I'll wait to see if Vijay can pull off the reason that he came to Vical in the first place. Vical has several hits yet on goal to trigger a nice run-up in it's stock price. Naked-DNA can be vaccinated over & over without danger to the body that antisense technology has been proven to cause. Either way, I wish us both good health . Hang in there ! : )
He and the secretary walk away with tens of millions$. There have been hundreds of millions$ attempting to put a square peg in a round hole. My point has been for years to protect newbies from investing and losing their hard-earned money in what has been falsely portrayed as a "Revolutionary Cure" of which it is not!
I remember good people like bosssco & elvis who lost their life's savings. To this day I feel sorry for them. : (
Have a great day folks!
Why it's just automatic. " I can't help it." I have to hand it to him, in the end with 25 years of antisense drug failures , not one successful large scale phase 3 viable Isis drug , he and the secretary walk away with hundreds of millions $. Then, the honors continue to pile in from the crowds. Big Stan, with a stern straight face, states, "at least my heart was in the right place"! The secretary then stands up to several minutes of applause from the geniuses, states, " I've come a long way baby !! " Meanwhile, the big pharma collaborators with Isis over the decades look at each other in puzzlement thinking. " Ya don't suppose we've been snookered " ? Then, they pat each other on the back and say, "heck no, we had a paying job for 25 years and gave suffering people hope to no avail." Darkout was right , the answer is gene therapy after all. Oh well. zzzzzzzzzzzzzzzzzzzzzz
Have a wonderful day !