He has the innate ability since I came on board to to skim the cream off the milk without breaking the bottle.
Yes, there are the same problems existing with antisense therapy, although, you would never know it by reading this message board. In July I will give you my twice a year update on antisense technology... stay tuned.
Best to you from Darkouttonight. Chuckle.
Jetman is accumulating Vical if he's as smart as what I think he may be. More accumulation now than later as the storm settles. Dr. Kus , jetman's friend from the OGXI board did not follow my advice to sell OGXI at $22. Sour , I don't take any of the Isis pumpers serious as 99% have no idea what antisense relates to in medicine. Enjoy the day my friend.
Sour I was concerned about your health and glad you're breathing along with me. A few times I had put feelers out for your ID with no reply and to be honest I thought the worst. I had a nice run with BMY, CELG, AMGN in and out with TASR. Once in a while I pick up a few more shares of Vical in the $1.05 area and hoping for the best. Since late 2013 Vical's IR has not answered my calls or E-mails... there is a reason for same. As of last week the plaintiffs are falling by the way side and of no concern to me. Our group is waiting several years for an isis safe antisense drug to be developed. Antisense compounds remain a problem, liver effects etc. Antisense targeting I have always liked and supported, that's basically where it remains this date. Antisense targeting has been Dr. Crooke's savior as you must know by now. I am selling BMY for dry powder and adding to TASR and increasing cash holdings for pull backs . Hang in there Sour ... so good to hear from you.
You may be right on VJ , however, he is no fool. Vical is working on exciting areas in naked-dna targets. Jet, for 100 cents a Vical share new stockholders own a terrific option on the future . The Isis stock price has discounted their unproven future. Let's hope for the best with both biotechs.
I have to give Dr. Crooke credit for tossing it to Ogxi after Isis had completed a trial with same. Out of 31 Isis patients enrolled the result was no clinical response in all 31. Ogxi's stock price went up very high, as it declined , finally at the $22 area I placed my Strong Sell on Ogxi.
I noticed that the TV personality hyping Isis is quite ignorant with regard to antisense technology.
I maintain all of our Vical shares with good reason ! Remember, there is no sure thing in biotech drug investment.
The best to all !
I have accumulated large amounts of AGEN & GNCA instead of RNN after looking over the books & clinical data of same.
Holding , BMY, VEEV, VJET & every share of VICAL. RNN has good news today, however, it appears favorable leverage compared to Isis. Dr. Crooke looked healthier last evening than his last hype. Good luck !
Not much new here to my mind... all expected as I stated in 2008. We shall see how the competition measures up in the end. Hope for the best... wish you well.
There have been more than 82 antisense compounds that have entered the clinic in over 130 indications, with Isis as sponsor or licensor of approximately two-thirds of these. Despite this massive R&D effort, only a two products have been approved for marketing by the FDA. They have received a very narrow label and have smaller sales. I believe most of the small investors in Isis are quite gullible and may live in the young age of entitlement. I wish them all the best ! I also hope Isis succeeds in helping humanity with non-toxic antisense oral treatments. Remember, antisense has no cure for any disease and is large molecule. Problems with antisense therapy do exist to this day. I could go on & on.
Yes, I still hold Vical and recently have added a large amount for my family. I've always stated, " be careful investing in biotechnology companies as all are risky'. Good luck all & hope for the best.
Said results were not sustained and remain yet to be validated such as the antisense technology. Let's hope for the best !
Have a great day my friends !
Hi my friend Jetman.
This is so unlike you and I wish you well. I purchased VEEV last week, BMY, AGEN and GNCA. This morning I reminded a few of our followers of certain Vical assets such as Vaxfectin. Astellas is happy with their collaborations with Vical while paying the freight moving forward. BMY is researching Vical's Vaxfectin as I speak. The group is waiting for an Isis buyout in vain, however, the rumors persist enough to move the stock price up without a safe antisense drug. Yes, I have to hand it to Dr. Crooke's what appears to be smoke & Mirrors tactics. Hang in there ... wish you good health & success !
Oh yes and a note of good cheer to the loyal flock of Isis promoters... on Oct. first to the third 2014 Big Stan threw out 55,000 more Isis shares that he received for failing the last 25 years. Super sad but the Isis victims love it. More dilution on the way.
HARVON is the safe treatment answer for Hep-C & Liver damage ! Folks, seldom do I scan this board other than once a week in a limited manner. The psychotic Isis hypsters on this board who use or contribute in my name are humorous. Yes, I still like VICAL and ISIS and hope for the best for both, however, I have the most of my investments in BMY, CELG, MRK, LILLY & AMGEN.
Good health to all... from Darkouttonight.
Nothing has changed... no validation of antisense...Same hyping of nothing new. I still hope for the best with Isis & Vical. ! Good luck all!
Makes for interesting reading. Vical is hitting on all eight at this time. I wish all Isis & Vical investors good luck. Enjoy the summer!
Hello my friend jetman.
Nice to hear from you... actually I own a bit of AGEN too. However, they can't hold a candle to Vical if you look deep into Vical's technologies. I believe AGEN will be bought out by the latest next year at this time. Vical will most likely be grabbed by one of three "big pharma" companies too. I see where this antisense company also will have to be merged due to old shorty fast growing weaker. Shorty, has milked the Isis cow to the dark extreme end of the no revolutionary story. He can only beg for a break through so many years before the true validation of a round antisense peg will not fit in a square hole.
In the mean time stay healthy. : )
I'm working on Micelles (PMS) at this time. Isis's lack of oral delivery is keeping their scientist going double time to correct this serious flaw relating to Antisense. Dr. Crooke stated he had the oral delivery problem solved in 1999 with the Elan collaboration... of course that was not true. I don't have the time to convince or engage the genius who is very angry at my exposing the flaws of Antisense drugs.
I Wish you & them luck with a chuckle & chortle. : )
Also, have added over 100,000 Vical shares since last Oct. under $1.45. Please, do your own DD on Vical as it's not as easy to predict as Antisense advanced chemical modifications are clear to me! Remember, all biotech companies are very risky!
Have a pleasant weekend . Chuckle. : )
This morning I took a minute to listen to the motley silly dialogue promoting the Isis pipeline. " Isis has more home runs " in the future. " I don't want to get into the science." Sorry folks , Isis has never had an Antisense phase 3 clinical trial home run ! So, you two Isis motley propaganda rascals, "Don't want to get into the science" of dark antisense Isis drugs? Why not ? I'd love to debate you both on why Antisense drugs have failed to be viable since 1984.
Newbies, be careful. I too hope that some future time Antisense drugs will work safely, however, that day has yet to come. : (