I don't normally respond or read comments on this board or especially the other dark controlled wantabe board. I have a few minutes today to research Vical's news release so I decided to scan a few on Yahoo. Have a great day. : )
a lead generators gold mine. Lawyers will target thousands of claims against Kynamro producers. Think !
I say wait until you can come up with a safe antisense drug. Have a great weekend ! Hmmm.
A dark freebie paradise for years.
Come to think of it he gave himself a gift over & over for the last 20 years . Fast Frankie hints , the suckers won't catch on ever since Dr. Dorr was fired. Ouch! : (
Crooke has been selling his freebies since $10. I'll bet he is shocked to see Isis selling near $40... matter of fact I know he finds it hard to believe ! Chuckle with a chortle. Good news for him as the board will replenish approx a million shares just to him, nope, not for you. Ouch ! I'm glad the stock is making a few bucks for the long suffering stockholders. I hear that most of the long holders sold and then bought back in at higher prices. Hey, as long as they make a few bucks... so what. I wish them all well. I'll bet the genius is quite nervous as the stock price nears his $40 plus average.
Yes, vaccines will play a major role in disease ! It beats the once a week toxic spike . Think of it , smokers smoke for years before it's too late. Oh well, the Isis fairy tale will end soon enough but the funds don't care as long as they make a buck. : ( Sad. Good luck all... Sour, where are you? : ) I added a large amount of Vical shares today. Chuckle.
We have a lot to be thankful for and I'm taking the time to enjoy same ! Chuckle . : )
Truthsayer e-mailed me that there are a few Isis hypsters that are afraid of me. I have no idea as to why other than certain people that do not like the facts of antisense. Let's all hope that Isis antisense investigation can develop a safe Spinal Muscular Atrophy drug. Have a good weekend to all. : )
The Crooke is a great salesman and I admire him for being able to sell lye soap to Estee L. I remember when S. Weil loved the antisense story and had Citi purchase eight million Isis share when there was less than halt the float now. Citi lost their shirt on that one... zing ! Want to hear when I advised Lilly not to pay $300 million for antisense rights ? Lilly was approx. $75 a share and never recovered from that disaster either...zing. Yes, the geniuses on this board stated, "Who do you believe the Lilly scientist or darkouttonight? " Chuckle with a grand Chortle. Cripes, I have a whole slew of them coming to my mind but I have to leave . Antisense surely tantalizes scientist into believing that they can solve the problems that others can't and this is good. Good luck all and I hope antisense will succeed in the end.
Your friend, darkouttonight. : )
Problems with antisense therapy still exist after all of this time. Antisense compounds have a short half-life in plasma due to destruction by cellular enzymes such as DNase which is ubiquitous in the body. This, combined with the need for these compounds to be administered parenterally, make them inconvenient for chronic treatment of systemic diseases. The lack of ability to cross the blood-brain barrier also limits the use of antisense compounds. Other problems, include nonsequence specific interaction through the oligo backbone. Because of their polyanionic nature, the phosphorothioate compounds are still able to bind to various factors. Yes, the target sequence-specific, independent inhibition has improved since 1989 but far from solved.
This baloney of new generations (2, 3,4) is promoted by modifying the base -- but permutations in their base structure is limited. Some of the analogs are able to increase the RNA binding affinity. However, concomitant changes in the backbone are necessary in order to maintain nuclease resistance. Sure, ISIS attached via the linkage to a 2 prime position. Still, one problem is these modifications are that they do not activate RNaseH and therefore require an RNaseH independent terminating event!
So antisense still is flawed by interactions with proteins, enzymes and other cellular factors. Add on the flaw of stability in body clearance, site specific delivery and plasma half-life and the blood clotting time, complement activation, LIVER effects and Thrombocytopenia. There is much more to state and I will do it from time to time.
Genius, thanks for the 14 years of chuckles. You mention Fidelity which just got crushed $130 million by their mistake investing in ARIA. I don't think you want to hear the rest of the story... chortle. I see that you and the other geniuses couldn't come up with the name of one Isis successful viable antisense drug in 24 years. Yet, to read a few lines of your nonsense a naive person would think Isis has 27 new antisense drugs. Genius, I can't hold your hand forever, so, try to wake up. Have a great day & thanks for the 14 years of classic humor. : )
Sure, I can show you a few hundred false statements in the last 15 years that portray that Isis has anywhere from 27 potent drugs in pipeline in 1999 . Where are they now? Remember the Isis Crohn's drug that the ceo pushed all around the world ? Why , he even received an award in N.Y.C. before it failed ! Yes, I have to admit the ceo is a wonderful salesman that has been known to sell ice to the Eskimos. I still hope the best for humanity's sake. Soon, if you like... I will educate you on my once a year expose of the flaws of antisense drugs. Remember, antisense is only good for targeting as I have explained since 1999. Gene therapy is the future... ask the ceo ! : )
Yes, only here to protect the newbies. : ) Your friend, Darkouttonight.
No wonder banks & #$%$nd managers have been misled into purchasing 79% of the Isis float. SCARY !
This writer for Motley #$%$ wrote on Oct. 21st 2013, "Isis develops CURES for rare diseases". Isis has never developed even one CURE for disease in it's 24 year antisense history ! Matter of fact, since 1984 there has never been one viable success#$%$l antisense drug developed by any one ! ! The needle in the eye failed to bring one dime to the Isis bottom line and Mipo will be the same. However, I warned you all about the MIPO liver problems etc. since 2007. Sorry folks but enough is enough !
I'm only here to protect the newbies. Have a great day ! : )
AEGR will clean Mipo's clock or what ever you're calling the K spike today. I wish Isis well but the safety problems of K are causing patient dropouts left & right. GENZ made a bad mistake and knows it ! Antisense seems to be only good for targeting as I have been stating since 1996. I give the Isis insiders a salute for selling every scrap of freebies as soon as they get their hot little hands on same. The salute is for taking advantage of the geniuses... nothing more. Hopefully, some day there will be a successful viable antisense drug... none yet ! HINT ! ( NO ORAL & LARGE MOLECULE ) Catching on yet? No, I didn't think so ! BTW, don't forget about Vical. : )
Isis approaching $5 Billion market cap with not one viable successful antisense drug in 24 years. Think ! Let's hope for the best some day. Your friend darkouttonight. : )
Isis was also the sister & wife of Osiris the Egyptian God of the lower world . Who in turn was the brother and husband of Isis. My, my, be very careful here. Chuckle with a chortle. : ) Yes, it's dark out tonight..
Vical has two already but let's wish them well for their CMV trials with Astellas. Hey, has anyone seen Dr. Andy Dorr ? You remember him don't you, he was VP in charge of Isis at the time of the $300 million fiasco with Lilly? Whoops, have a great day from Darkouttonight. Chuckle. : )
to their trash collectors. Where are they getting it from... chuckle. ? It's hard to believe that newbie funds would collect this no product waste dump. Hey, ya got to hand it to the little guy and his side-kick. Smirk. : )
The reason I didn't warn most analyst is that most all of them have no clue as to the technology path of antisense. I'm afraid there will be geniuses in the end who will be crying on this board to, "Sue the so&sos!" Due to the Isis DARK warnings not to take their news releases serious, the insiders have the right to milk this dry cow for every toxic drop that they can squeeze. I wish it weren't so , hopefully , some day there will be a safe antisense oral drug as the CEO promised in 1999. Alas, a spike every week is a disaster in the end. BTW, I keep adding to my Vical shares & hope a few of you people invested in Isis that have a profit, will see the light. : )
Remember, all biotechs are risky.
Your old friend darkouttonight : )