...latter is controlled-release taking as many as 12 hours for full release while Vicodin gets in in as little as 4 hours. Drug abusers will prefer Vicodin obviously. Also the Acetaminophen in Vicodin for those taking 2 tabs every four hours is likely to cause liver damage eventually. The FDA surely knows these details. So does Mylan...
ACUR eats and breathes anti-deterrent formularies but this is not ready for prime-time. The ADF talk is just another excuse to shoot down Zohydro. The FDA says that CLASS II Scheduling of opioids is the key by reducing drug availability without punishing real patients.
The only significant difference is that Purdue's has a gimmickry anti-deterrent formulation supposed to prevent abusers from using drug intravenously. People could still abuse it via the oral route and only be bothered a little if snorted. The FDA got it right.: FOCUS on tight Class II schedule. Let doctors and pharmacists monitor closely every 30 days. Penalize infractors!
Mylan's Vicodin and Percocet have the most to lose. Manchin want only ADFs approved which is a way of buying time. ADFs will NOT prevent drug abuse but now instituted Class II schedule will. Doctors and pharmacists will have a better handle of the amount of pills out there. ADF is smoke and mirror. Might have alittle effect on IV drug users....but that is a small minority. IV abusers want heroin and the like...
New spin by bashers: Acetaminophen in pill is good cause it works as a deterrent. LOL -- Only if the purpose is to give abusers liver failure.
Excellent post! The con artists want people to believe ADFs will be the answer but the truth is clear, they want to kill the competition. Reduction in drug abuse will happen now with CLASS II Schedule. To snorters, ADFs have failed. They only have a little more nasal irritation than when using nonADFs. ADFs will not deter oral abusers(the majority). And as far as IV addicts, nothing will scare them(dirty needles, powder, pepper, whatever).
Schedule II will make patients visit gate-keeping doctors monthly, No more prescriptions for 6 months which made abuse easy. Also pharmacists will monitor users closely.
Politicians urging ADF approval are just doing what Big Pharma want, i.e., more time of exclusivity. Vicodin which is not a generic has much to lose.
The bottomline is money. The rest is fluff. New Class II for opioids is far more effective, and these same idiotic politicians might take credit for the significant drop in drug abuse, even in the absence of ADF(abuse-deterrent formulation).
The key is to get doctors and pharmacysts more involved. Class II will mandate that. Abuse-deterrent formulations will not keep abusers from popping more of the prescribed drugs. As far as snorters and IV users, these abusers will always find a way around the ADF. But the latter are just the minority of abusers. The vast majority used the oral route because there was a lot of drugs readily available. Under Class II they have to see their doctor every month. ADF will definitely raise prices but without reducing abuse. Enforcing class II is the thing!!!
And that includes Bloomberg which is supposed to be smart. but not infallible. The key to reducing abuse is thru better policing by doctors and pharmacysts. CLASS II designation will help without a doubt. ADF is not the answer today.
Because Zo is a new generation long-acting formulation it's probable that you end up taking less of the med with better clinical results. Not to mention avoiding the Acetominophen that has become a good thing to avoid. Herein is the irony of it all.
Anyone who says that is fooling you. To begin with most abusers will abuse drugs via the oral route. So, all it takes is to get more pills more often. But now that these drugs have become Class II pill counting by doctors and pharmacysts will become the rule and abuse will be reduced. Only a minority use the nasal or intravenous route. For those, probably there little to deter them. They always find a way, ADF just become a little inconvenience to them. ADF is still in its infancy. Ask specialist Acura Pharm about it.
" Please ban the percocet made by Mylan lab. It is urgent and pass a bill to do so." I'm sure Manchin will. ROFL
ADF is still in its infancy. Purdue's drug will show some undesirable side-effects once the full data is available based on anecdotal information. Study patients usually end up in regular community hospital for acute problems. And the nurses and doctors talk. Let's wait and see the incidence of drop-outs...and why...
I doubt his bill would ever come to a vote. There's no support other than that of the freaks.
He's a loose cannon, no doubt. Abuse-deterrent is not as good as his advertising. There's nothing better than a good doctor and a compliant patient. If Manchin's got nothing else to do, he should start selling his shares.of his daughter's company.