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Amarin Corporation plc Message Board

dinepat203 313 posts  |  Last Activity: 3 hours ago Member since: Sep 29, 2011
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  • One company, Celldex (NASDAQ:CLDX), has seen great appreciation in its stock price due to its lead drug candidate, rindopepimut (CDX-110), a targeted immunotherapeutic which is now in Phase III. The market cap of Celldex in this presently challenging biotech market (due to Fed comments twice this year) is now at $1.2 billion and was 3 times higher earlier this year. So, if Ziopharm can demonstrate very early success in this open label trial to that level or greater, then I am sure that it would at least add $100 million or more to its market cap in Phase I to Phase II. And there is such a great need for a treatment of Glioblastoma and treatment will likely end up being the best of what is to be seen in a combo treatment either after success of singular trials with great success, or a required combo treatment trial as determined by the FDA or data to come.

  • Reply to

    New headline on

    by bostonblackie02066 Aug 19, 2014 2:48 PM
    dinepat203 dinepat203 Aug 19, 2014 3:31 PM Flag

    Sources: National Cancer Institute; National Cancer Institute Physician Data Query (PDQ); American Cancer Society Cancer Facts & Figures 2014; Cedars Sinai Brain Tumors and Brain Cancer web page; GLOBOCAN 2012; CRI grantee progress reports and other CRI grantee documents Last Updated June 2014 -
    Urgent Need
    It is estimated that 1 in 161 individuals born today will develop brain or nervous system cancer at some point in their lives. In the U.S., 23,380 men and women are diagnosed with cancer of the brain and nervous system every year, and 14,320 deaths are caused by the disease. Although significant advances have been made in understanding the biology of brain cancers—as well as in tumor diagnosis, treatments, and quality of life of patients with the disease—the mortality rate for brain cancer has remained steady for more than 30 years. The cause of brain tumors is not yet understood. Glioblastoma (GBM) is the most dangerous and aggressive form of brain cancer. GBM patients typically have short-term life expectancies; few will live to see three years after diagnosis. For newly diagnosed GBM patients treated with current standard of care, median progression free survival is just 6.9 months, and median overall survival is 14.6 months. Only a quarter of newly diagnosed GBM patients survive for 24 months, and under 10% of patients survive more than 5 years. -
    Rindopepimut (CDX-110), a therapeutic vaccine targeting a mutant peptide called EGFRvIII, that is expressed in approximately one-third of GBM tumors. Rindopepimut is currently being tested in the following trials that are enrolling patients with EGFRvIII positive tumors: a phase III trial in patients with newly diagnosed glioblastoma (NCT01480479) and a phase II trial in patients with relapsed glioblastoma (NCT01498328). For information on the 3 phase II trials of rindopepimut that formed the basis for the current randomized phase III trial, see Celldex’s recent news release summarizing the results.

  • Reply to

    New headline on

    by bostonblackie02066 Aug 19, 2014 2:48 PM
    dinepat203 dinepat203 Aug 19, 2014 3:15 PM Flag

    "The ACT IV study will include 700 patients with EGFRvIII positive glioblastoma from more than 200 clinical trial sites across 22 countries—the most comprehensive study conducted by a biotech company to date in this orphan disease. We are extremely proud of our team and very grateful to the patients, families and physicians who are participating in this study.

    In the second quarter, we also accomplished a number of additional, significant milestones—advancing our accelerated approval study of glembatumumab vedotin in triple negative breast cancer, publishing positive data from the CDX-1401 program, presenting positive data from our Phase 1 varlilumab program at ASCO and announcing a clinical trial collaboration with BMS for the varlilumab program. This momentum is expected to continue in the second half of 2014 as we initiate multiple new studies across our pipeline and present data from our Phase 2 ReACT study in recurrent glioblastoma at year-end

  • dinepat203 dinepat203 Aug 19, 2014 12:53 PM Flag

    Not to worry with Micky mouse games of retail traders - 92% institutional HOLD GOOD ENOUGH to get the leap jump on fine day.

  • dinepat203 dinepat203 Aug 18, 2014 3:49 PM Flag

    Jul 23, 2014 - Alan Auerbach, CEO, president, and chairman of Puma Biotechnology (NYSE: PBYI ) , you just personally made over $700 million after your biotech suddenly soared 295% (more if ... Puma's current market cap is $7 billion.

  • dinepat203 dinepat203 Aug 18, 2014 3:32 PM Flag

    Pfizer’s (PFE) anti-4-1BB antibody PF-05082566 reached a safe dose in Phase 1 without undue toxicity signals (ASCO 2014, Abstract #3007). Pfizer disclosed combination trials with rituximab in Non-Hodgkin Lymphoma (NHL) and pembrolizumab (anti-PD-1). The BMY antibody urelumab was tolerated through its’ dose escalation cohorts, and ex vivo analysis showed activation of CD8+ T cells and NK cells (ASCO 2014, Abstract #3017). The Celldex anti-CD27 mAb also has demonstrated safe dose escalation, although to date without signs of clinical activity (ASCO 2014, Abstracts #3024 and #3027). Celldex (CLDX) claims planned studies in combination with nivolumab, ipilimumab, and the targeted therapeutics darafenib and trametinib.

  • Reply to

    We are coming down the stretch

    by grey3840 Aug 18, 2014 3:02 PM
    dinepat203 dinepat203 Aug 18, 2014 3:29 PM Flag

    Its $23Million in value transaction.

  • Reply to

    We are coming down the stretch

    by grey3840 Aug 18, 2014 3:02 PM
    dinepat203 dinepat203 Aug 18, 2014 3:27 PM Flag

    If 1.5Million volume cannot bring this down what balls do you have?

  • Reply to

    CLDX by 2014 end = ITMN ($13 to $53)

    by dinepat203 Aug 18, 2014 12:50 PM
    dinepat203 dinepat203 Aug 18, 2014 2:54 PM Flag

    Institutional Ownership
    91.99%
    Total Shares Outstanding (millions)
    89
    Total Value of Holdings (millions)
    $1,237

  • Reply to

    CLDX by 2014 end = ITMN ($13 to $53)

    by dinepat203 Aug 18, 2014 12:50 PM
    dinepat203 dinepat203 Aug 18, 2014 2:01 PM Flag

    Roth Capital Reiterates Buy On Celldex Following 2Q14 Results, Keeps $40 PT

  • ReACT's Avastin refractory cohort was expanded following positive interim data in late 2013. More than 50 sites are open (goal ~100 sites) for patient screening for the accelerated approval METRIC study of glembatumumab vedotin in metastatic TNBC, and the company plans to expand the drug into Phase II studies in metastatic melanoma and squamous cell lung cancer in 2H14.”

    Pantginis sees Celldex solidifying itself as a “premier cancer immunotherapy company” with a broad pipeline and robust partnering potential.

  • dinepat203 dinepat203 Aug 14, 2014 3:53 PM Flag

    Bristol, Celldex Collaborating on Cancer Immunotherapy Study by Adam Feuerstein
    Posted on May 21, 2014
    The phase I/II study will combine Bristol’s PD-1 checkpoint inhibitor nivolumab with Celldex’s CD27-targeted antibody varlilumab, also known as CDX-1127. Multiple tumor types will be treated, including non-small cell lung cancer, melanoma, ovarian, colon and head-and-neck cancer.‘

    ‘Nivolumab works by removing a cloaking mechanism used by cancer cells to hide from the body’s immune system. Bristol intends to file nivolumab for FDA approval as a new treatment for advanced lung cancer before the end of the year.‘

  • dinepat203 dinepat203 Aug 13, 2014 2:37 PM Flag

    Steve Brozak - WBB Securities - Analyst : Okay. Last question

    I noticed that the UK acceptance is off the charts here, and they are usually the most conservative, and obviously they are always looking at cost constraints and such. Can you tell me why they are close to 100% in terms of on the KOL acceptance side.

    Unique insider clinical opinion - KOLs report

    This new KOL Insight report Breast Cancer –new targeted therapies transform treatment provides everyone interested in this dynamic cancer sector with a complete understanding of the targeted products which are shaping the current landscape and the research which will change future treatment paradigms.

    Every aspect of the report is informed by insights gained from thorough 60-minute interviews with 12 experienced key opinion leaders (KOLs) from across major markets to provide expert views on the current treatment landscape and how it will change in the future. KOLs are selected based on their clinical experience, authored scientific publications, involvement in clinical trials and with the Pharma industry, their participation in treatment guideline development, and their record of presenting at high-profile in

  • dinepat203 dinepat203 Aug 13, 2014 2:16 PM Flag

    Did you noticed ? Some buying activity for 266,000 shares at Avg price of $15.25 today at 1:53pm !!

  • dinepat203 dinepat203 Aug 13, 2014 2:09 PM Flag

    $16 shortly but $20 ? can't say.

  • dinepat203 dinepat203 Aug 13, 2014 1:59 PM Flag

    This report Published on Aug 06, 2014 and was Priced $106.00

    Bret Holley - Guggenheim Securities - Analyst : Thanks for taking the questions. I'm just wondering on the commercial front with rindo, with the service that you've done, I'm just wondering if you explored kind of a sensitivity analysis to the OS benefit? I think, as said, versus the six-month benefit, they'd be highly enthusiastic. And I'm just wondering if you explored, like I said, kind of a range of benefits from where there might be a cut off in sensitivity to or enthusiasm about patients using rindo in vIII positive glioblastoma?

  • Question: Jonathan Aschoff - Brean Capital - Analyst : Congrats on the progress. I was wondering, the unconfirmed PR with the renal cell patient at ASCO on 1127, is that a confirmed PR now?

    Question: Jonathan Aschoff - Brean Capital - Analyst : Great. Thank you. And rindo recap data in late 2014, do you mean SNO or after the SNO conference?

    Question: Jonathan Aschoff - Brean Capital - Analyst : Okay. And two more. Bristol, does Bristol still determine if data from the 1127 PD-1 trial will or will not be released, or is it already clear to them that that is immaterial to Celldex?

  • dinepat203 dinepat203 Aug 13, 2014 11:16 AM Flag

    That said, Norman added that he fully expects Ebola to come into the United States and Europe at some point in the future. However, being able to treat Brantly and Writebol in the United States actually gives doctors and other medical staff valuable experience, so that they can learn more about the virus and make better preparations.

    "We know what we're dealing with now and can deal with it," he said. "I think we're going to learn a lot more about the biology of the virus over time."

  • Reply to

    Interesting article with reference to Rindopepimut

    by texreb59 Aug 11, 2014 4:36 PM
    dinepat203 dinepat203 Aug 12, 2014 12:31 PM Flag

    By Cathie Gandel
    August 11, 2014 11:57 AM

AMRN
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