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Aegerion Pharmaceuticals, Inc. (AEGR) Message Board

dinepat203 466 posts  |  Last Activity: Jul 24, 2014 12:24 PM Member since: Sep 29, 2011
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  • Reply to

    DCVax Works Dr. Aman Buzdar Confirms

    by dinepat203 Jun 20, 2014 12:47 PM
    dinepat203 dinepat203 Jun 20, 2014 12:50 PM Flag

    Several types of vaccines for boosting the body’s immune response to kidney cancer cells are being tested in clinical trials. Unlike vaccines against infections like measles or mumps, these vaccines are designed to help treat, not prevent, kidney cancer. One possible advantage of these types of treatments is that they seem to have very limited side effects. At this time, vaccines are only available in clinical trials.

    There are several ways to create vaccines that might stimulate the immune system:
    ◾ In one approach, cancer cells (removed during surgery) are altered in the lab to make them more likely to cause an immune response and are then returned to the body. In another approach, a special virus is altered so it is no longer infectious, but it carries a gene for a protein often found on cancer cells. Once the virus is injected into the body, the hope is that the protein will cause the immune system to react against cancer cells anywhere in the body.
    ◾ In another approach, immune system cells are removed from the blood. The cells are treated with cytokines and exposed to killed tumor cells to make cells called dendritic cells. These cells are then injected into the body to stimulate the immune system to fight the cancer. Early results have been promising, but more studies are needed.

    Combining vaccines with targeted agents or other agents to help them work better is also being studied.

  • A newer approach to treatment is the use of a virus, known as JX-594. This started as the same virus that was used to make the smallpox vaccine, but it has been altered in the lab so that it mainly infects cancer cells and not normal cells. A solution containing the virus is injected into liver cancers, and the virus can enter the cancer cells, where it causes them to die or to make proteins that result in them being attacked by the body’s immune system. Early results of this treatment against advanced liver cancer have been promising, even in patients who have already had other treatments, DCVax Direct does exactly same as JX-594 virus which helps to kill the Cancer Cells and boost the human immune.

  • Reply to

    My Email to MD Anderson

    by dwiggd Jun 20, 2014 10:46 AM
    dinepat203 dinepat203 Jun 20, 2014 11:01 AM Flag

    NW Bio continues to make strong progress in multiple programs with two product lines, for both operable and inoperable tumors, and as NW Bio's clinical programs show encouraging early effects, Feuerstein seeks ever more sensationalized ways to try to smear the Company. This is not even the semblance of professional analysis. We condemn this attack campaign and appreciate the strong support we are receiving from shareholders, patients and other commentators. We intend to continue our progress undeterred

  • Reply to

    My Email to MD Anderson

    by dwiggd Jun 20, 2014 10:46 AM
    dinepat203 dinepat203 Jun 20, 2014 10:56 AM Flag

    Dr Aman or who so ever - NEVER NEVER reply to anyone on same day. Common sense - How come Dr. Aman can reply which he is not involved in?

  • The Phase II stage of the trial will focus on efficacy. The primary measure of efficacy will be regression (i.e., shrinkage or elimination) of the patient’s existing inoperable tumors. Such regression is a rapid endpoint: if it is going to occur, is anticipated to occur within a couple months of treatment.

  • dinepat203 dinepat203 Jun 20, 2014 10:12 AM Flag

    Dr never gives comments on things which he never sure or aware of ....
    Secretary at MD Anderson clearly informed that send your concern by email or fax and they will reply if it is necessary and appropriate if it is required and that to in writing.

  • So does he understand that being said .....It is MD Anderson site .
    Adam made 2 false statement

    In response to my questions, MD Anderson's spokesperson asked me to speak with Dr. Aman Buzdar - Dr Aman Never answers any call from anyone. Even President Obama is on the line. Secretary asked Adam to leave his message and come back to him after Dr. Review his concern.

    Why Adam is not diclosing this facts that Dr. refused to provide any further details other than looking into matters and call him back.

  • MD ANDERSON is a party to the patients File Records and Biopsy Performed at the Site.

    There has been significant interest in this trial, and the Company has been receiving many requests for data updates, as this trial is testing a novel treatment for patients with late stage, inoperable tumors – patients for whom there are virtually no treatment options today. The data released by the Company came from the medical files at the clinical trial sites and reviews of imaging and biopsies, and was provided by the sites and pathology labs, as well as a respected and independent clinical research organization (CRO) managing the trial.

  • Reply to

    DRs Training FROM HONO...LULU .......LOL

    by dinepat203 Jun 20, 2014 9:41 AM
    dinepat203 dinepat203 Jun 20, 2014 9:42 AM Flag

    Adam FAURESTEIN training is from?

  • EDUCATION
    Degree-Granting Education
    Government Emerson College, Multan, Pakistan, FSc, 1962
    Nishtar Medical College, Multan, Pakistan, MB,BS, 1967
    Postgraduate Training
    Rotating Intern, Kaukini Hospital, Honolulu, HI, 1968−1969

  • I called this number and left a message with so called breast cancer Dr.Aman U. Buzdar. Secretary now replied he never spoken with anyone name Adam Furestein.

  • SHORTS cannot borrow and will see how things goes from there...

  • I believe quote by Albert Einstein (kind of a smart guy) where he said the following:
    Insanity: doing the same thing over and over again and expecting different results.

    Adam Furkestein = 3 Lies identified

    1 - Buzdar, an oncologist by training, spoke by phone about Northwest Bio on Wednesday. ( Wednesday 18th June 2014 - Buzdar is available only at his clinic 1515 Holcombe Blvd Houston, TX 77030 (713) 792-6161. during 8:00 AM - 12:00 PM and 1:00 PM - 5:00 PM - No phone call conversation with any STOCK BLOGGER - Secretary confirmed)

    2 - But Buzdar said investigators at MD Anderson and the two other hospitals conducting the DCVAX-Direct study have not reviewed or analyzed data at all because patients are still being enrolled and treated.

    ( How and Why Buzdar comment about other hospitals conducting trials?)

    3 -First AF writes that according to Dr. Aman U. Buzdar - NWBO made statement first that NWBO disclose preliminary and unconfirmed results from individual cancer patients who have had single, inoperable tumors injected repeatedly with DCVax-Direct. ( Note here the information is from Individual Patients)

    then Dr. Aman U. Buzdar made - The statements being made by Northwest Bio about DCVax-Direct are derived from patient case report forms, which the hospitals are obliged to send to the company because it sponsored the study.

    How Buzdar can make 2 statements ? -
    1. Results are directly from Patients
    &
    2. From Patients case report which MD Anderson obliged to send to company .

  • dinepat203 dinepat203 Jun 19, 2014 8:13 PM Flag

    But Buzdar said investigators at MD Anderson and the two other hospitals conducting the DCVAX-Direct study have not reviewed or analyzed data at all because patients are still being enrolled and treated.

    ( How and Why Buzdar comment about other hospitals conducting trials?)

    First AF writes that according to Dr. Aman U. Buzdar - NWBO made statement first that NWBO disclose preliminary and unconfirmed results from individual cancer patients who have had single, inoperable tumors injected repeatedly with DCVax-Direct. ( Note here the information is from Individual Patients) then Dr. Aman U. Buzdar made - The statements being made by Northwest Bio about DCVax-Direct are derived from patient case report forms, which the hospitals are obliged to send to the company because it sponsored the study.

    How come Dr.Aman U. Buzdar make 2 statements ? -
    - Results are directly from Patients and
    -- From Patients case report which MD Anderson obliged to send to company .

  • dinepat203 dinepat203 Jun 19, 2014 8:07 PM Flag

    1. Buzdar, an oncologist by training, spoke by phone about Northwest Bio on Wednesday
    ( Wednesday 18th June 2014 - Buzdar is available only at his clinic 1515 Holcombe Blvd Houston, TX 77030 (713) 792-6161. during 8:00 AM - 12:00 PM and 1:00 PM - 5:00 PM - No phone call conversation with any STOCK BLOGGER - Secretary confirmed)

    2. But Buzdar said investigators at MD Anderson and the two other hospitals conducting the DCVAX-Direct study have not reviewed or analyzed data at all because patients are still being enrolled and treated.
    ( How and Why Buzdar comment about other hospitals conducting trials?)

    3. First AF writes that according to Dr. Aman U. Buzdar - NWBO made statement first that NWBO disclose preliminary and unconfirmed results from individual cancer patients who have had single, inoperable tumors injected repeatedly with DCVax-Direct. ( Note here the information is from Individual Patients) then Dr. Aman U. Buzdar made - The statements being made by Northwest Bio about DCVax-Direct are derived from patient case report forms, which the hospitals are obliged to send to the company because it sponsored the study.

    How come Dr.Aman U. Buzdar make 2 statements ? -
    1 Results are directly from Patients and
    2. From Patients case report which MD Anderson obliged to send to company .

  • Reply to

    Reuters article posted part1

    by homework.investwell Jun 19, 2014 7:59 PM
    dinepat203 dinepat203 Jun 19, 2014 8:05 PM Flag

    1. Buzdar, an oncologist by training, spoke by phone about Northwest Bio on Wednesday
    ( Wednesday 18th June 2014 - Buzdar is available only at his clinic 1515 Holcombe Blvd Houston, TX 77030 (713) 792-6161. during 8:00 AM - 12:00 PM and 1:00 PM - 5:00 PM - No phone call conversation with any STOCK BLOGGER - Secretary confirmed)

    2. But Buzdar said investigators at MD Anderson and the two other hospitals conducting the DCVAX-Direct study have not reviewed or analyzed data at all because patients are still being enrolled and treated.
    ( How and Why Buzdar comment about other hospitals conducting trials?)

    3. First AF writes that according to Dr. Aman U. Buzdar - NWBO made statement first that NWBO disclose preliminary and unconfirmed results from individual cancer patients who have had single, inoperable tumors injected repeatedly with DCVax-Direct. ( Note here the information is from Individual Patients) then Dr. Aman U. Buzdar made - The statements being made by Northwest Bio about DCVax-Direct are derived from patient case report forms, which the hospitals are obliged to send to the company because it sponsored the study.

    How come Dr.Aman U. Buzdar make 2 statements ? -
    1 Results are directly from Patients and
    2. From Patients case report which MD Anderson obliged to send to company .

  • Reply to

    AF = 3 Lies identified

    by dinepat203 Jun 19, 2014 7:42 PM
    dinepat203 dinepat203 Jun 19, 2014 8:01 PM Flag

    Can SEC investigate this as Mkt manipulations ?

  • dinepat203 by dinepat203 Jun 19, 2014 7:42 PM Flag

    1. Buzdar, an oncologist by training, spoke by phone about Northwest Bio on Wednesday
    ( Wednesday 18th June 2014 - Buzdar is available only at his clinic 1515 Holcombe Blvd Houston, TX 77030 (713) 792-6161. during 8:00 AM - 12:00 PM and 1:00 PM - 5:00 PM - No phone call conversation with any STOCK BLOGGER - Secretary confirmed)

    2. But Buzdar said investigators at MD Anderson and the two other hospitals conducting the DCVAX-Direct study have not reviewed or analyzed data at all because patients are still being enrolled and treated.

    ( How and Why Buzdar comment about other hospitals conducting trials?)

    3. First AF writes that according to Dr. Aman U. Buzdar - NWBO made statement first that NWBO disclose preliminary and unconfirmed results from individual cancer patients who have had single, inoperable tumors injected repeatedly with DCVax-Direct. ( Note here the information is from Individual Patients)

    then Dr. Aman U. Buzdar made - The statements being made by Northwest Bio about DCVax-Direct are derived from patient case report forms, which the hospitals are obliged to send to the company because it sponsored the study.

    How come Dr.Aman U. Buzdar make 2 statements ? -
    1 Results are directly from Patients and
    2. From Patients case report which MD Anderson obliged to send to company .

  • dinepat203 dinepat203 Jun 19, 2014 3:51 PM Flag

    That is some amazing results. I wonder since it is a small company producing it they would be more or less likely to give the drug to one of us on a compassionate basis.

    DX 10-05 stage IV
    liver resection 12-05
    Folfox + Avastin 1-05 to 7-06
    Liver resection 8-07
    Folfiri + Avastin 9-07 to 3-08
    DVT resulting in angioplasty 1-08
    Liver resection 12-11
    Clean scan finished chemo 7-9-12
    Clean scan 7-10-13

  • Personally my interest in this technology is because of the concept of a dendritic cell vaccine. Ralph Steinman won a Nobel Prize in 2011 for his discovery of the role of dendritic cells in adaptive immunity. If one's own immune system can recognize and memorize the characteristics of cancer cells, then cancer would have a hard time to to take hold in one's body (Dendritic cell functions to teach the immune system to recognize other cells).

    Past attempts of dendtritic cells cancer treatment involved the use of immature dendritic cells. What's different about DCVax-Direct is the dendtritic cells used here is partially matured then injected back into the tumor. Supposedly this will allow the DC cells to better pickup tumor antigens.

    Since this technology is from a tiny development stage biotech company based in Maryland, it lacks the marketing prowess of a Merck or a Roche, so you won't hear much about it from the mainstream media. But in concept, the vaccine approach to cancer treatment is just as if not more promising than all the immune checkpoint inhibitors (PD-1/PD-L1, CTLA-4) that are all the buzz right now.

AEGR
30.00Jul 25 3:59 PMEDT

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