I think there is still a promising future for Prana's science, and see this as a temporary setback.
“Before success comes in any man’s life, he is sure to meet with much temporary defeat, and, perhaps, some failure. When defeat overtakes a man, the easiest and most logical thing to do is to quit. That is exactly what the majority of men do. More than five hundred of the most successful men this country has ever known told the author their greatest success came just one step beyond the point at which defeat had overtaken them.”
― Napoleon Hill, Think and Grow Rich
And to quote Donald Fagan
Standing tough under stars and stripes
We can tell
This dream's in sight
You've got to admit it
At this point in time that it's clear
The future looks bright
On that train all graphite and glitter
Undersea by rail
Ninety minutes from new york to paris
Well by seventy-six we'll be a.o.k.
What a beautiful world this will be
What a glorious time to be free. Less
Thanks Pivalde, That would a huge market for PBT2. Once the rest of the science community realizes how important the balance of these trace metals are, Pranas valuation will go much higher in my opninion. As Rudy said in a recent interview they are very few others companies in this field.
Tom, I have been a long of Prana for may years and want to thank you for sharing your experience. The longs on this board are investors with a lot of compassion towards those afflicted by AD. This is also true of Pran's scientists and management . As is have stated before that is capitalism at its best my friends.
Dr Neil Telling from the University of Keele, who lead the research in collaboration with colleagues at the University of Warwick and the University of Florida, commented: "Alzheimer's is a sensitive and emotive area of research. The disease involves progressive brain cell failure, the reasons for which are still not fully understood. When findings showed increased levels of toxic iron within Alzheimer's disease tissues, we realised that techniques we had used to study other iron based materials could be applied to understand where this toxic iron came from. Our observations suggest an origin for the toxic iron; that it may well be made toxic by the lesions themselves. This could open up new avenues of research into treatments to stop the build-up of this neurotoxic substance, potentially limiting the damage done by Alzheimer's. Understanding how this toxic iron forms could also tell us where to look for early stages of the disease in MRI scans, perhaps even before irreversible brain damage occurs. It's at an early stage but these promising results seem to be another piece of the jigsaw to fully understand Alzheimer's."
Yes I recommend everyone read this major new paper google below.Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide β-amyloid (1–42)
J. Everett1, E. Céspedes1, L. R. Shelford2, C. Exley3, J. F. Collingwood4, J. Dobson5,6, G. van der Laan7, C. A. Jenkins8, E. Arenholz8 and N. D. Telling1⇑
+ Author Affiliations
More information: The full research paper "Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide β-amyloid (1-42)" was published in Journal of the Royal Society Interface on Wednesday, 26th March 2014 DOI: 10.1098/rsif.2014.0165.
A related paper was published recently online by the same research team in the journal ACS Inorganic Chemistry entitled "Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimer's Disease Peptide β‑Amyloid" DOI: 10.1021/ic402406g.
Journal reference: Journal of the Royal Society Interface Inorganic Chemistry
In a paper published today, British scientists have found evidence that biological material contributing to lesions in the brain, characteristic in Alzheimer's patients, may also cause the build-up of brain-cell-damaging toxic iron. Scientists have made the discovery using advanced imaging techniques at giant X-ray facilities - the Diamond Light Source synchrotron in Oxfordshire and other synchrotrons in Switzerland and the US.Iron occurs naturally in the human body, including the brain. The conversion of this iron between two chemical forms is essential for normal function. However, one of these forms of iron, known as ferrous iron, can be highly toxic if it is overproduced or builds up in tissues where it can't be processed and removed properly. Scientists have known for some time that this toxic iron builds up in the same location as the brain lesions caused by Alzheimer's disease.
Researchers have been studying the protein fragment that makes up the Alzheimer's lesions, a peptide known as beta-amyloid, to try to understand how and why the build-up of toxic iron is occurring; and whether it's a cause or a symptom of the brain cell damage in Alzheimer's patients.
At the UK's national synchrotron, Diamond Light Source, beams of light 10 billion times brighter than the sun, were used to shine a light on the problem, to study the chemical and magnetic makeup of the iron after it had interacted with the beta-amyloid peptide. By using these techniques along with electron microscopy they witnessed predominant biological form of iron changing into the more toxic ferrous form. As well as Diamond Light Source, studies were also carried out at the Swiss Light Source and the Advanced Light Source in the USA, using applied advanced x-ray techniques, more commonly used to study the latest hi-tech materials.
The experiments revealed that the peptide that makes up Alzheimer's lesions is capable of converting iron into the form which could be causing damage to brain cells. This means that the lesions caused by Alzheimer's could be causing a subtle disruption in how the brain manages iron, confronting brain cells with a level of toxicity that they simply cannot manage.
This discovery paves the way for future medical research into treatments that could halt or manage the conversion of iron into this toxic form, potentially slowing or limiting the damage to the brain. It could also lead to developments in using magnetic resonance imaging (MRI) to detect early stages of the disease by mapping altered patterns of iron in the brain.
I like that idea . and I do find it unusually they have a webcast for the breakout session in NY. This could make for a very interesting day. Onwards and upwards.
Thanks Kad , the Susan Lindquist Study and all of the other independent papers supporting the metals theory.