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Synthetic Biologics Inc. Message Board

don_quixote123456 494 posts  |  Last Activity: 1 minute 45 seconds ago Member since: Jun 3, 2000
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  • Reply to

    6 million left in the Bank

    by mdr0418 2 hours 47 minutes ago
    don_quixote123456 don_quixote123456 1 minute 45 seconds ago Flag

    I doubt it will go that low, even if it goes off now. Too much coming up to go off that low. IMO

    Sentiment: Strong Buy

  • Reply to

    Brain and immune system

    by fighterpilot 1 hour 1 minute ago
    don_quixote123456 don_quixote123456 32 minutes ago Flag

    Again, why do you think Kirk selected SYN?? What did SYN have that he couldn't have gotten or built through any of his other company, including XON?!!!

    T-R-I-M-E-S-T-A

    He was willing to bet BIG on it.

    And I agree, HUGE is too small a word for what it could be worth.

    Just sayin'.

    GLTAL

    Sentiment: Strong Buy

  • Reply to

    Don't be duped into selling

    by gamespeopleplay80 55 minutes ago
    don_quixote123456 don_quixote123456 37 minutes ago Flag

    A lot of us are too smart to give up shares. We are only buying when we get the funds to do so!

    We KNOW WHAT WE OWN!! :)

    Sentiment: Strong Buy

  • Reply to

    Roche 'High Efficacy' MS Drug Succeed in Trials

    by cyg2011 Jun 30, 2015 7:56 PM
    don_quixote123456 don_quixote123456 3 hours ago Flag

    I know you know this, but keep in mind, Trimesta is estriol, not estradiol. Very different. Estriol is weaker and does not pose the same cancer risk estradiol doesn't. You recall "Its weakness is its strength."

    Just clarifying for the newbs and the illiterates.

    Sentiment: Strong Buy

  • don_quixote123456 don_quixote123456 3 hours ago Flag

    Ahahahaha!!

    Thanks for the morning laugh!!

    Sentiment: Strong Buy

  • don_quixote123456 don_quixote123456 4 hours ago Flag

    Do you really think longs care where this goes today? The whole market is down, and with the jobs report, folks are counting on a rate increase. Just reactionary. Longs are VISIONARY. Longs are also up 50% in June! What's your flipping % for June? Have you made 50%??? Kind of doubt it. :)

    Sentiment: Strong Buy

  • don_quixote123456 don_quixote123456 5 hours ago Flag

    "...Such information has import not only to the study of MS pathobiology, but also to considerations for neuroprotection and neurorepair.”

    The study could help direct new treatments, which in the past only focused on inhibiting the immune attack on myelin. Future therapies may also focus on inhibiting general death of cells in the brain, known as “neuroprotective strategies.” Neuroprotective strategies have been explored in degenerative diseases such as Alzheimer’s and Parkinson’s disease. The present study suggests that neuroprotection, particularly at early stages, could be helpful for treating MS.

    Just thought I'd remind folks why Trimesta is important and why current drugs are not enough, even though they help with relapses. Some drugs are worth the wait!!!

    GLTAL

    Sentiment: Strong Buy

  • "Researchers from Canada and the U.S. have found that brains of young people with multiple sclerosis fail to develop fully. The article appeared November 5, 2014 in the journal Neurology entitled, “Onset of multiple sclerosis before adulthood leads to failure of age-expected brain growth.”

    Multiple sclerosis is caused by an immune system attack on a fatty substance called myelin, which insulates the axons that branch off of brain cells, and speeds the flow of information in the brain and spinal cord. Myelin appears white, leading to the term “white matter,” as opposed to “grey matter,” which refers to cell bodies that are not wrapped with myelin. MS has been mostly viewed as a white matter disorder, however, new evidence may point toward degeneration of the grey matter as well.

    Led by Dr. Bérengère Aubert-Broche of the Montreal Neurological Institute at McGill University, the scientists used magnetic resonance imaging (MRI) in thirty-six patients who had been diagnosed with relapsing-remitting MS before they were 18. Relapsing-remitting is the most common MS type. Images were taken at the beginning of the study and two years later. They also looked at the MRI scans of 364 healthy people without MS who were in the same age range, taken over two years, to see what typical brain growth looks like.

    The images showed an unfortunate finding. Brain growth was not as great in the people with MS, especially in a region called the thalamus. The thalamus is the “central station” of the brain, where information from lower and higher brain regions comes together. In young people with MS, having a smaller thalamus also corresponds with a smaller region of the spinal cord, known as thoracic region 2, which is found in the upper back.

    The authors of this study concluded “Our data provide compelling evidence that neurodegeneration is an early aspect of MS pathology, rather than a late effect of chronic disease, even in children and adolescents...con't.

    Sentiment: Strong Buy

  • don_quixote123456 don_quixote123456 18 hours ago Flag

    We also wouldn't be enrolling new sites in the 1st IIa if there wasn't indication that it was working as intended, particularly since we have already gone into 2nd IIa. Tells me management does not want to have a 'low power' issue ever again! :) They intend to show without a doubt that SYN-004 WORKS as intended!

    IMHO

    Sentiment: Strong Buy

  • don_quixote123456 don_quixote123456 22 hours ago Flag

    I'm guessing no. LOL

    Took the afternoon off, decided to do some yardwork instead. Didn't think we'd get any news this afternoon, so figured why not.

    The Greeks are messing with the world, investors have bigger fish to fry, it's a waiting game for now. I imagine, much like us in the USA, smart Greeks are wondering how they've sunk so far from the original 'great thinkers'. It's pretty sad a country that spawned the likes of Pythagoras, Archimedes, Artistotle, Plato, Sophocles et al -- can also spawn Tspiras and Varoufarkis. Same as Madison, Washington, Franklin, Hamilton et al are turning in their tombs over BO, Reid, Pelosi and the rest of his posse! WT heck happened to the DNA, some sort of cosmic burst that fried out all the good stuff!!!?? It's been downhill in this world for awhile now. Let's not forget the majority of Germans voted for Hitler! And look how great that turned out. And the Germans had Keplar, Benz, Daimler and more!! Just makes you shake your head. Who puts these morons in charge?!

    Sentiment: Strong Buy

  • Reply to

    Roche 'High Efficacy' MS Drug Succeed in Trials

    by cyg2011 Jun 30, 2015 7:56 PM
    don_quixote123456 don_quixote123456 Jul 1, 2015 2:07 PM Flag

    Thanks for the insight. Helps to keep perspective.

    Sentiment: Strong Buy

  • don_quixote123456 don_quixote123456 Jul 1, 2015 2:06 PM Flag

    10 cents! Woot!

    LOL

    Wake me at $5.

    Sentiment: Strong Buy

  • Reply to

    Not covering to the 2.50's, yes, the 2.50's

    by fdigiovanni0i Jul 1, 2015 1:04 PM
    don_quixote123456 don_quixote123456 Jul 1, 2015 2:06 PM Flag

    LOL

    Where did you short?? Let me guess...$3.22? Can you even short SYN?

    Sentiment: Strong Buy

  • Reply to

    JUNE JUNE JUNE, well it's JULY 1,

    by imnotadamf Jul 1, 2015 8:17 AM
    don_quixote123456 don_quixote123456 Jul 1, 2015 10:31 AM Flag

    Of course, that could happen. Someone could beat us to the punch on 'cognitive for MS'. There is always the risk in biotech that someone could beat you to the punch.

    Don't get me wrong, SYN is not riskless. It is just when you look at the big picture, all the shots at goal we have, the risk/reward ratio is very, very attractive -- to me. Others might want their money in GICs!

    But if you're in the market, and if you like small cap biotech and its prospects, I believe SYN should be your #1 holding. So far, it hasn't done me wrong. Slow and steady gains, with some volatility built in for traders, means SYN has something for everyone to enjoy.

    GLTU

    Sentiment: Strong Buy

  • Reply to

    Is this good or bad?

    by kgjie Jul 1, 2015 10:13 AM
    don_quixote123456 don_quixote123456 Jul 1, 2015 10:25 AM Flag

    OK, anyone else on Etrade having same problem? or any other brokerage?

    Sentiment: Strong Buy

  • Reply to

    Is this good or bad?

    by kgjie Jul 1, 2015 10:13 AM
    don_quixote123456 don_quixote123456 Jul 1, 2015 10:15 AM Flag

    No shares to be had and naked shorts are trying to find shares to cover!

    LOL

    Maybe it's just a glitch.

    Sentiment: Strong Buy

  • Reply to

    Roche 'High Efficacy' MS Drug Succeed in Trials

    by cyg2011 Jun 30, 2015 7:56 PM
    don_quixote123456 don_quixote123456 Jul 1, 2015 10:14 AM Flag

    jlukenjj is correct. They do not have to make offers public -- unless it's an offer to buy the whole company! But not to sell a product, not until it's a done deal.

    Sentiment: Strong Buy

  • don_quixote123456 don_quixote123456 Jul 1, 2015 10:11 AM Flag

    Yes, you got it.

    I must have glanced through that sentence because in my mind, I only saw '2b on track for 3rd quarter'.

    On the trial summary for IIa, the Columbus site had been listed as 'not yet enrolling', even as of yesterday, other sites were 'recruiting'. From the beginning, SYN was targeting up to four sites for the trial, so I guess I always assumed they were still going with it. My guess is that they are now enrolling Columbus and possibly one other site.

    The good news is that now everyone is enrolling. For that to happen, there must already be some patients at the first site showing that SYN-004 works. Remember, it is quick to show efficacy or not. Maybe the laddered enrollment was so that no money was wasted until good results were beginning to be collected. Then, they needed more patients to power the results. Actually, with their cash position, waiting a little to get some preliminary info before enrolling other sites was probably the best idea!

    Sentiment: Strong Buy

  • Reply to

    JUNE JUNE JUNE, well it's JULY 1,

    by imnotadamf Jul 1, 2015 8:17 AM
    don_quixote123456 don_quixote123456 Jul 1, 2015 10:01 AM Flag

    You make a good point. He obviously had confidence that data would arrive by a certain time. When it was clear that would not happen, he let us know. We have all known this was out of his control and we are all waiting for Dr. V to do her thing. Keep in mind, he was not the one that secured the deal with UCLA, so presumably some things were set up a little, let's say, loosely.

    That said, often things take time and unforseen factors cause delays. That does not negate what Dr. V has stated about Trimesta or the purpose for the spin-off cognitive trial in the first place. At this point, you are betting on whether you believe in the science or not? If Trimesta truly helps with cognition and it can be proven definitiely, you must know there will be an offer(s). Why else would they keep acquiring patents on the product if it did not work and did not have value??!

    Just turn off your alarm clock, enjoy your sleep and wait until someone wakes you up with the good news!!!!!!

    GLTAL

    Sentiment: Strong Buy

  • Reply to

    June -- up $1.00 PPS. What will July bring?

    by fireball_money Jul 1, 2015 9:12 AM
    don_quixote123456 don_quixote123456 Jul 1, 2015 9:37 AM Flag

    I know, aren't those guys funny -- up 50% on the month and they call longs 'losers'! I can't wait to find out what a 'winner' is!!!

    And trust me, I plan to!

    :D

    Sentiment: Strong Buy

SYN
2.605-0.175(-6.29%)2:40 PMEDT