As much as I an optimistic about the prospects of their current science I still have memories of the shock when Pali testing was abandoned and the stock plummeted. There had been just as great a build up of expectations preceding this, accompanied by significant shorting advocates who were resoundingly proved correct. There are huge expectations of success built into the current stock price.
My decent sized position in ZIOP has grown in the last 10 months to be by far my single largest holding. I remain optimistic with memories of Pali creating apprehension.