brian12372, it is not crazy to test the low limits for yourself. I would say it is a good engineering principle and practice, because you will be in all kinds of different and unexpected situations over time. You can establish the limits you can push it now when you are in a controlled environment rather than taking unwarranted chances when you might be in an emergency or other type situation. Better now with apple juice available rather than no availability :-) .
michaelmurphy234, you should read Psycho Analyst's recent articles on Seeking Alpha in which she talks about Bydureon's dangers to your health. If you are not concerned about your diabetic health relative to $15 extra per month, no one cares but you.
centralcoastinvestor, Al let us know the $50 million milestone was to meet the Afrezza volume availability for product launch by January 23. He said MNKD met the milestone two weeks early. Al also said the yields of Afrezza were better than forecast.
brian12372, that's pretty incredible! You were at 232 yesterday when you were an Afrezza virgin, and you took a 4 U dose of Afrezza. You mentioned it went to about 202 in 14 minutes, and this morning at breakfast you took a 12 unit Afrezza that has you at 90 mg/dl now. Looks like you are seeing the same action with Afrezza as afrezzauser. Very impressive if I have understood it all.
mikesmilitaria, I have tried to get doctor.stockpicker's attention on the problems of his prescribing Metformin, but I have never gotten any replies from him. I share your concerns about Metformin, but doctors appear to prescribe it all the time to Type 2 diabetics. That practice should stop I hope with Afrezza's availability. I lifted your Metformin post below. Maybe you can get doctor stockpicker's attention.
"That one pill per day, like Metformin is poison.
The RX of which you speak forces the body to "circumvent excess sugar" and pass it thru the kindeys and out via urination. Now if sugar(diabetes) destroys your organs and now with that one pill a day, you put the kidneys thru handling excess sugar, day in, day out, what ultimate effect will that process have on your kidneys? That is one of the box warnings on the one pill per day.
Afrezza is natural human MONOMERIC insulin that has a therapy profile identical to that of the pancreus.
It has NO adverse side effects and "balances the body's sugar" the way nature intended.
Metformin takes the pancreus and forces/squezzes the organ to produce insulin so you in fact, take a weak, barely functioning organ and wear it out, pushing you to T1 diabetes from T2."
Part 1 and Part 2 is better:
stanleyttu, I have to start with some basics that you probably know, but I want to be thorough. The product you call insulin that you put in your pump is not really the chemical insulin a healthy human pancreas secretes. It is an insulin analog, that is, it is very similar to human insulin in the number of amino acids (51 to be exact), but it has some alkyl group substituted on the real human insulin molecule. Insulin analogs are very powerful, meaning they are very, very efficient (work fast) in causing glucose metabolism. Insulin analogs have to be in very low concentration (diluted) in your blood stream. If you were to inject a small dose of an insulin analog directly into a vein, your blood glucose would be metabolized in a very short time and you would get a hypoglycemic event very, very fast. So that is why you have to insert the needle or catheter under the skin. The skin gets locally saturated with the insulin analog, and it secretes slowly into your blood stream all day. Real human insulin from the pancreas is not as efficient as these insulin analogs, and that is good. Otherwise we would never have survived as the human race. Since human insulin metabolizes blood glucose more slowly, the normal pancreas dose secreted can vary a lot and still not create hyperglycemia or hypoglycemia. We all know in normal people there are high metabolism people and lower metabolism people (and everything between), and the reasons are myriad. How quickly or slowly their blood glucose is metabolized is certainly a factor.
Comparing dose units for an insulin analog to dose units of Afrezza seems non-linear and not prone to a simple formula (as much as that would be desired and you would desire it). With a type 1 or type 2 diabetic using Afrezza I think of their lungs as a substitute pancreas, because the lungs secrete the identical human insulin their pancreas would secrete. The dose is up to you, and it will likely require some experimentation on your part. Based on the paper below you will likely be able to tolerate a wide range of carbohydrates once you establish a dose (or my input: a range of doses). With your pump pumping basal and bolus insulin analog, are you already getting the kind of in-range mg/dl blood glucose results that Afrezzauser is getting with his Dexcom meter? If so, you are already in very good control. If you are not in good control, you should try Afrezza. I read that brian12372 tried a 4 unit Afrezza dose first, and observed his blood glucose come down. Then at breakfast he said he tried a 12 unit dose and could feel his blood sugar lower. You will likely need to experiment too, and you may not want to do that. If you insist on a formula, you may not want to be an early adopter of Afrezza.
If you google pubmed 23046397 , you will find a paper from Sansum Diabetes Institute and Mannkind giving details of ranges of carbohydrates consumed, including no meal at all, using Afrezza. No severe cases of hypoglycemia were observed. Afrezza appears very safe in lots of dose amounts. The paper concludes with
Results in eight patients suggest that once an optimal dose of TI is determined, type 2 diabetes patients can ingest meals with a wide range of carbohydrate content or even skip meals without severe hypoglycemia. During this pilot study TI therapy improved A1C by -1.63% (P=0.00091) during 19 weeks of treatment.
I noticed uncharacteristic posts, and then I noticed redhaw_20000 (redhaw twenty thousand) is trying to impersonate redhaw_2000.
sellhighdrinklow, you are clearly not a type 1 diabetic. There is a time line involved. Go back and review your readings. Also afrezzauser stated he has his Dexcom set to alert at 150. If you still represent yourself as a diabetic, get yourself an Afrezza prescription and enjoy the benefits. It will answer your questions.
I can see on my Fido quotes they are charging 29% to borrowers of MNKD shares. I have not called to see how much of that they pay the owner of the shares. When they charged 24.75% it was about 17.5% paid the owner as I recall. At 29% I would imagine Fido pays 22.5% or so. Just think about this. For those shares in taxable accounts that are on margin Fido is getting all 29% of that money!! Most of the shares that will be loaned out of these IRA type cash accounts will be borrowed by market makers who will service their options customers.
Why would a practicing physician label a topic "Important factual information" on a yahoo message board? Oh, now I get it. It's like Saul Goodman telling clients he is a "criminal" lawyer.
tasermania, it is $8.5 not $8 for 2/13. it is Aug $12s not May. I don't know whether you transcribed these incorrectly, or if your data source has it mixed up. Just FYI so others do not get wrong call option numbers from your post. I checked my work just now. It looks like a lot of hedging to me.
Please notice the dot between doctor and stockpicker to recognize the legitimate doctor who posts real medical information here.
winwina88, Sanofi will drop the news on you like the Swiss Central Bank dropped the Swiss Franc news today.
Godin said he is in Canada and will have to wait until Afrezza comes to Canada. He said at the end of the two year Afrezza trial his A1C was 5.9. If I were he, I would be making a run for the border.
bullcall56, I don't want to loan out my shares either, and I own a Lot of MNKD shares. Yes, the shorts do have a problem in that Afrezza works much better with far less complications than almost anyone knew it would. It did not take that much work or due diligence to realize Afrezza, once dissolved, is identical to the insulin secreted by the pancreas, but it is secreted upstream from the lungs instead (that is even better for diabetics). That is not what Exubera was. So there was some chemistry and physiology to know, but for as many $$ as these shorts were betting they could have found people who would have explained it to them. How about they could have even gone to MNKD and tried sincerely to understand how Afrezza works. Maybe it's like Shaq says, "Analytics against me is going to lose everytime." Perhaps the shorts relied too much on FDA phase 3 trial data before making bet after bet. I've looked at maybe six or seven people (maybe more) on twitter who have gotten prescriptions for Afrezza who had never tried Afrezza, and from the first dose noticed consistent glucose control for highs and lows they never had achieved or thought possible. Their results are like Afrezzauser's results, but Afrezzauser appears to be more rigorous in his plan to push his control over his blood glucose.
dahustlastrikesagain, you should read brian12372's input. He was an Afrezza virgin until late yesterday, and today he is getting blood glucose numbers that are like afrezzauser's, who knew what Afrezza would do for him due to his Afrezza phase 3 trials two years ago. One day Al Mann's standard reply to all the Afrezza testimonials will be, yea, I get that a lot.
factspls88, this is all related to options that the market makers do to service those big 20k and 70k puts and calls you see the past few days. the market makers are just servicing some long or short customer that wants to take a position.