stupidity is not a cause of action in most jurisdictions….but if it were, monetary awards would exceed the relatively low economic threshold set for small claims court.
but Affirnity and Synergy are different tests. strange that 011 is now in 3 Phase III tests, great if news on Synergy is positive, I wonder what happens if it is not.
Box, I will spend the next month thinking positive thoughts about 011…to quote the character in Toy Story "to Infinity and beyond".
Failure on 011 condemns ASO drugs at least on a temporary basis. There is no toxicity or safety problems in fatal cancer drugs. OS only concern. Severe dilution on taking 427 forward.
we cannot kid ourselves. Absolute disaster if 011 fails.
Fencing, a small company can't control data release. All they can do is meet their guidance.
I anticipate release of data when most inconvenient to me. I will be in the Baja May 12 week, thus forcing me to watch a computer screen whilst I should be drinking tequila and watching scantily clad women walk up and down the beach. It is not fair; but it is a burden that I am willing to shoulder.
Hi tc, I wouldn't get hung up on ASCO date. This testing process for the drug has taken 10 years overall. Surely the company wants to read out the data in the most time effective, accurate manner. Why be rushed by ASCO?
Howard please try 200 words or less. Being succient is an attribute (so I hear as I have never attained it).
I have waited a long time on this one.
the only theory that I have is that all is unknown, and even that is too certain of a point of view.
I wish Howard could explain in 100 words or less how God views the binary event. Is God neutral? Engaged? Or does He cheer on the good efforts of the doctors and scientists leaving our fate untouched?
I think it is a close call. but I have no statistical abilities, let alone math models to run with. I will pray and abstain from drinking too much (relatively speaking) in the interim in the hopes of influencing the test results. This may not be scientific. But I feel better.
Hi Box, I am getting nervous. Read out closing in on us. I agree with you on what will happen on unsuccessful results. may go lower if general markets are still hammering biotech's.
In my view, the accretion has nothing to do with earnings - what earnings? what guidance can come from the meeting?
We are waiting for read out on lead drug after a decade of waiting to see if this new platform will be validated.
Risk takers are moving in both directions. Shorts protecting themselves; others buying shares for hold and sell on ramp up. High demand, few shares, immense upside, validation of antisense platform in cancer space. Isis success overarches this stock.
There are two options: 1. sheer disaster, or 2.uber-hyper-superman-type-success-only-Neitzsche-could-predictt.
I choose 2, but will reluctantly accept 1.
Hi There Mr. Sabres. Sounds like you did the right thing. I have added and held. In retrospect we should have sold at 42 in 2009, bought in now. but what would we have done with our time? what would we have fretted about? Maybe its in my nature, I have been waiting for the Leafs to win a Stanley Cup since 67. Thank God for the Canadian Olympic mens and women's teams. Stephen
I agree with many of your points, this drug took too long, but I am not blaming anyone. They bumped up against the 2008 meltdown, their product was of limited interest to big pharma because of competing developments. The Teva deal was not perceived well, but that judgment will be made down the road. The slow accretion in pps leading to the decision is not unprecedented since MDVN and ISIS did the same. Witness the subsequent exuberance after approval.
But in my view, a positive result will validate the pipeline and hurl 427 into the limelight, a drug 100% owned and ready for action in six indicators. We may be seeing the irrationality of the market now in ignoring OGXI, but the irrationality of the market will benefit us upon approval of 011. Possible range: $3 to north of $100.
The revelations that are most pertinent for me have occurred in a mixed Raki - Swedish massage session, usually when the weather outside approximates 25 C, and my massage therapist is Norwegian (preferably Danish) in her appearance. I think God likes the Nordic people. They certainly kicked butt in the Winter Olympics.
In my limited experience, God seems preoccupied with my many failings as a human being. As you say, great details are provided. Much like my wife, but God says it more succinctly and in a kinder, gentler way. He has expressly referred to certain rules to follow (10 of them I think) but I have no recollection of this Feuerstein-Ratain rule. Perhaps He hopes I remain poor. If that is my fate, I will accept it. I just won't be able to get anymore of those great massages.
good analysis. Safety profile of 011 has never been a risk, so that would certainly raise concerns. 427 is the super drug here, but the dilution that would go on would hurt us badly.
Alternatively, think of 011 success and 427 owned and commercialized by OGXI.