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Alnylam Pharmaceuticals, Inc. Message Board

dragan7777777777 117 posts  |  Last Activity: 8 hours ago Member since: Apr 20, 2005
  • dragan7777777777 by dragan7777777777 Dec 6, 2014 10:24 AM Flag

    Bottom line: colonoscopies are not more accurate that Cologuard, plus extremely unpleasant procedure and there are significant risks, like bleeding,
    bowel perforation ( meaning emergency bowel surgey, laparotomy ), anesthesia complications, even deaths. ColoGuard will cut the number of colonoscopies as a first line screening procedure, but colonoscopies will not be eliminated, unfortunately in spite of all risks......

  • dragan7777777777 by dragan7777777777 Dec 6, 2014 10:16 AM Flag

    Colonoscopies are considered the gold standard for colon cancer screening.

    MedPage Today reports a recent study from the Annals of Internal Medicine, that suggests it’s much less accurate than initially thought. The problem was with detecting right-sided cancers, where “the test missed just about every cancer in the right side of the colon, where cancers are harder to detect but about 40 percent arise. And it also missed roughly a third of cancers in the left side of the colon.”

    Instead of the 90+ percent improvement in mortality rate that’s commonly quoted, the authors suggest the number is closer to 60 percent to 70 percent.

    That’s a surprising finding, and needs to be validated by future studies. If true, how will it change current recommendations? Will colonoscopies be recommended to be performed more frequently? Should fecal occult stool cards be performed in between colonoscopies? Will this affect the role of virtual colonoscopies?

  • dragan7777777777 by dragan7777777777 Dec 6, 2014 10:14 AM Flag

    "Highly Accurate At-Home Colon Cancer Test Approved
    DNA analysis of stool boosts accuracy rate of Cologuard to more than 90 percent, researchers say"

    HealthDay Reporter

    MONDAY, Aug. 11, 2014 (HealthDay News) -- The U.S. Food and Drug Administration on Monday approved a new at-home, DNA-based stool test that screens for colorectal cancer with more than 90 percent accuracy.

    The decision was based on an FDA panel's unanimous decision in March that the benefits of Exact Sciences Corp.'s Cologuard test outweighed its risks.

    "This approval offers patients and physicians another option to screen for colorectal cancer," Alberto Gutierrez, director of the Office of In Vitro Diagnostics and Radiological Health at the FDA's Center for Devices and Radiological Health, said in an agency news release.

    Last year, nearly 143,000 new cases of colorectal cancer were diagnosed in the United States and almost 50,000 Americans died of the disease, according to the U.S. National Cancer Institute.

    A study published in March in the New England Journal of Medicine found Cologuard had a very high accuracy rate in spotting colon cancer.

  • How often colonoscopies are done in US?:

    Approximately 2.8 million flexible sigmoidoscopies and 14.2 million colonoscopies were estimated to have been performed in 2002. Physicians reported that they could perform an additional 6.7 million flexible sigmoidoscopies and 8.2 million colonoscopies in 1 year. These additional procedures could be used for the unscreened population and should be considered in the estimate of the national capacity to provide colorectal cancer screening to all eligible persons in the United States.

    Risks of colonoscopy?:

    According to a study published in the Annals of Internal Medicine, for which researchers reviewed colon cancer screening data from 1966 to 2001, the most severe complications from colonoscopy are perforation (that occurred in 0.029% to 0.72% of cases), heavy bleeding (occurring in 0.2% to 2.67% of colonoscopies) and death (occurring in 0.003% to 0.03% of colonoscopy patients).[36][37]

    Severe dehydration caused by the laxatives that are usually administered during the bowel preparation for colonoscopy also may occur. Therefore, patients must drink large amounts of fluids during the days of colonoscopy preparation to prevent dehydration. Loss of electrolytes or dehydration is a potential risk that can even prove deadly.[39] In rare cases, severe dehydration can lead to kidney damage or renal dysfunction under the form of phosphate nephropathy.[40]

    As with any procedure involving anaesthesia, other complications would include cardiopulmonary complications such as a temporary drop in blood pressure, and oxygen saturation usually the result of overmedication, and are easily reversed. Anesthesia can also increase the risk of developing blood clots and lead to pulmonary embolism or deep venous thrombosis. (DVT)[39] In rare cases, more serious cardiopulmonary events such as a heart attack, stroke, or even death may occur; these are extremely rare except in critically ill patients with multiple risk factors. In very rare cases, coma associated with anesthesia may occur.

  • dragan7777777777 by dragan7777777777 Dec 6, 2014 9:19 AM Flag

    Why is EXAS hitting 52 wks high, even on market red days? Let me see:

    Colon cancer is a killer. One of the most common cancers ( incl lungs, breast, prostate ). So far the only screening test is colonoscopy. Although sensitivity and specificity are far from 100%, colonoscopy is the best screening test that medicine can offer. Save lives and allow biopsy. Similar but much more expensive and less accurate is swallowing disposable ( one time use ) colon mini-camera. Generally doctors advise to have first colonoscopy at age 50. If patient has colon polyps or family history of colon cancer colonoscopy should be done much earlier and every 2-4 yrs.

    Great, except one "small" problem. If you ever had colonoscopy you will understand why people avoid having one. First you have to starve for a few days or week ( rules vary from place to place ), you can eat only liquid food. Then you have "bowel prep" the day before. Bowel prep is very unpleasant thing. You drink some laxative and spend all day on the toilet and on the morning of colonoscopy you feel dizzy, tired and hungry. Then they place you on exam table, start intravenous and give you IV sedation. Aside of undignified exposure you get enough IV sedation that is almost close to TIVA ( total intravenous anesthesia ) because colonoscopy hurts. Well, but colonoscopy save lives.

    Then came ColoGuard! More accurate, non invasive, no bowel prep, no IV sedation. But more expensive?! Not really, if you take in account money paid for nurse, scope doctor, booked room, IV drugs. I would pay any time 500$ to avoid starving for days, bowel prep and IV drugs. No wonder med insurance companies are willing to pay those 500. Not to say that colonoscopy will be terminated procedure, but to say that ColoGurad will become med standard and first line of colon cancer screening.

    EXAS has golden goose, ColoGurad. Oh, yes, they have strong pipelines, as well, working on early detection of other cancers. EXAS will become ATM machine and some deep pocket pharma will buy them out. Now you know why is EXAS hitting 52 wks high and why will smart money keep loading up. I am long and will add more on any dip. Good luck shorts.....

  • Reply to

    just bogus

    by hotheadjim Dec 5, 2014 11:32 AM
    dragan7777777777 dragan7777777777 Dec 6, 2014 8:05 AM Flag

    Nice theory. How about: efficient market theory? It says everything is priced in according to its value.
    This is pumped up garbage and it will be priced accordingly.....

  • dragan7777777777 by dragan7777777777 Dec 5, 2014 3:28 PM Flag

    Really. What a joke......And no one will buy it now for peanuts. Why? Because it is all smoke and mirrors. Empty PRs and hype. Too bad no shares to short......

  • dragan7777777777 by dragan7777777777 Dec 5, 2014 10:35 AM Flag

    Another 'great" PR and PPS going down! Why? It is a scam......

  • dragan7777777777 by dragan7777777777 Dec 4, 2014 8:19 AM Flag

    750.000 total knees/year done in US!......

  • Reply to

    first post on new board

    by gladysz Dec 3, 2014 9:49 AM
    dragan7777777777 dragan7777777777 Dec 3, 2014 11:18 AM Flag

    Pretty exciting biotechnology, clinical trial phase 3 means well advanced....

  • dragan7777777777 by dragan7777777777 Dec 2, 2014 3:02 PM Flag

    Retail investors will never make any money here. Too bad no shares to short....

  • Reply to

    Where is it?....

    by dragan7777777777 Dec 1, 2014 9:49 AM
    dragan7777777777 dragan7777777777 Dec 1, 2014 1:39 PM Flag

    EPS = minus 0.16. Where is the beef?.....

  • dragan7777777777 by dragan7777777777 Dec 1, 2014 9:49 AM Flag

    The beef?....

  • No money in the bank, no real sales, all smoke and miorrors....

  • dragan7777777777 dragan7777777777 Nov 28, 2014 2:43 PM Flag

    On who payroll are you, Cramer, Adam or hegies?......

  • TKMR is 30-40$ stock, bring it down shorts so I can load up.......

  • dragan7777777777 by dragan7777777777 Nov 28, 2014 11:36 AM Flag

    Down to 10? Sure, will load the truck there. Oh, by the way, once more for shorts bull: Tekimra is NOT ebola stock only. Much more in pipelines....

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