CF patients will try anything but the side effects of Orkambi are horrible. Go to You Tube for personal experiences. The drug is also enormously expensive so Vertex is trying to force patients to stick with it.
The reason that 80 % of urologists have never prescribed Xtandi is because it is too dam expensive. That is why Congress is investigating MDVN. That is why urologists are prescribing Zytiga and insurance often cover it. Even more important is Zytiga is coming off patent.